报 告 一：Resarch Seminar on Neurodegenerative Diseases
报告专家：Prof. Frédéric SAUDOU (Ph.D.)
简介： Dr. Saudou received his Ph.D. from Louis Pasteur University and now is the Director of the Grenoble Institute of Neurosciences (GIN) at the University of Grenoble Alpes, France.
· Studying the normal functions of huntingtin and its role on neuronal functions
· Dysfunctional consequences of polyGlutamine expansion
1. El-Daher MT, … and Saudou F (2015) Huntingtin proteolysis causes toxicity through dynamin 1 dysregulation. EMBO J. 34 , 2255-71.
2. Zala D, … and Saudou F (2013) Vesicular glycolysis provides on-board energy for axonal transport. Cell. 152, 479-91. Highlighted in Nat Rev Neurosci, 2013, 14, 156-157; News & Views in Nature, 2013, 495,178-180. (Top 1% ESI)
3. Keryer G, … and Saudou F. (2011) Ciliogenesis is Regulated by the Huntingtin-HAP1- PCM1 Pathway and is Altered in Huntington Disease. J. Clin Invest, 121, 4372-4382.
4. Borrell-Pagès M., … Saudou F*. and Humbert S*. (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington’s disease through HSJ1b and transglutaminase J. Clin. Invest. 116, 1410-1424.
5. Gauthier LR, … and Saudou F (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118, 127- 138. (Top 1%)
报 告 二：Resarch Seminar on Nanotoxicology
报告专家：Prof. Michel SEVE (PharmD, Ph.D., DHDR)
Prof. Michel SEVE is the Dean of the Faculty of Pharmacy at the University of Grenoble Alpes and the Head of Promethee Proteomic Platform (UGA – Grenoble Hospital), France.
· Protein biomarkers research in cancer and other diseases
· Investigation of post-translational modifications in the control of metabolism in cancer cell
1. Lehmann SG et al. Tubulin beta-3 chain, a new protein biomarker of human skin aging. Oxid Med Cell Longev. 2017; 2017:5140360.
2. Michelland S et al. A low-molecular color pI markers to monitor on-line the peptides focusing process in OFFGEL fractionation. Electrophoresis. 2017; 38(16):2034-2041.
3. Martín-Bernabé A. et al. Quantitative proteomic approach to understand metabolic adaptation in non-small cell lung cancer. J Proteome Res. 2014; 13(11):4695-704.
4. Chenau J et al. The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells. J Proteome Res. 2009; 8(10):4579-91.
5. Chimienti F et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci. 2006; 119( 20):4199-206.