陆朦辰

发布者:金雪明发布时间:2021-09-22浏览次数:1990


姓名:陆朦辰

职务职称:博士,副教授,硕士生导师

联系邮箱:mclu@suda.edu.cn

联系地址:苏州大学独墅湖校区二期药学院云轩楼2508

 

一、    学习与工作经历

2021.06–至今:苏州大学医学部药学院,副教授

2020.062021.05:中国药科大学,副研究员

2017.06-2020.06:中国药科大学药学院,博士后

2012.09-2017.06:中国药科大学药学院,药物化学专业,博士(硕博连读)

2008.09-2012.06:中国药科大学,药学专业,本科

 

二、    研究方向

主要研究方向为药物化学及化学生物学,通过运用药物设计学、化学生物学、药物化学等多学科交叉手段,开展靶向泛素E3连接酶的药物化学生物学研究及创新药物的研发工作。

 

三、    研究成果

作为项目负责人主持了国家自然科学基金青年基金项目一项、中国博士后基金面上项目一等资助、中国博士后基金特别资助一项。作为项目骨干参与了国家新药创制重大科技专项及多项国家自然科学基金项目。以第一作者在学科权威杂志Medicinal Research ReviewsJournal of Medicinal ChemistryRedox BiologyEuropean Journal of Medicinal Chemistry等发表论文15篇,申请专利2项,授权专利2项。

 

代表性论文:

[1] M. Lu, X. Zhang, J. Zhao, Q. You*, Z. Jiang*, A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions, Redox Biol. 34 (2020) 101565. IF = 9.986

[2] Lu, M.-C.; Shao, H.-L.; Liu, T.; You, Q.-D.*; Jiang, Z.-Y.*, Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions, Eur. J. Med. Chem. (2020). IF = 5.572

[3] M.C. Lu, X. Zhang, F. Wu, S.J. Tan, J. Zhao, Q.D. You*, Z.Y. Jiang*, Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity, J. Med. Chem. 62(14) (2019) 6796-6813. IF = 6.054

[4] M.-C. Lu, J. Zhao, Y.-T. Liu, T. Liu, M.-M. Tao, Q.-D. You*, Z.-Y. Jiang*, CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation, Redox Biol. 26 (2019) 101266. IF = 7.793

[5] M. Lu, T. Liu, Q. Jiao, J. Ji, M. Tao, Y. Liu, Q. You*, Z. Jiang*, Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway, Eur. J. Med. Chem. 146 (2018) 251-259. IF = 4.833

[6] M.C. Lu, Q. Jiao, T. Liu, S.J. Tan, H.S. Zhou, Q.D. You*, Z.Y. Jiang*, Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency, Eur. J. Med. Chem. 143 (2018) 1578-1589. IF = 4.833

[7] Lu, M.-C.; Ji, J.-A.; Jiang, Z.-Y.*; You, Q.-D.* The Keap1–Nrf2–Are Pathway as a Potential Preventive and Therapeutic Target: An Update. Med. Res. Rev. 36 (2016) 924-963, IF = 9.300

[8] Lu, M.-C.; Zhou, H.-S.; You, Q.-D.*; Jiang, Z.-Y.* Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1, J. Med. Chem. 59 (2016) 7305-7310. IF = 6.205