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张士磊

发布者:金雪明发布时间:2018-11-04浏览次数:2267



  名:张士磊

职称职务:教授

联系电话:0512-65880959

电子邮箱:zhangshilei@suda.edu.cn

办公地址:苏州市工业园区仁爱路199号药学院云轩楼

ORCID0000-0001-8169-0098

 

个人简介:

一、学习工作经历

1998.9-2002.7:中国海洋大学化学化工学院海洋化学专业,大学本科

2002.9-2007.7:中国科学院上海药物研究所,药物化学,博士学位

2007.7-2008.9:华东理工大学药学院药物化学系,讲师

2008.10-2012.1:美国新墨西哥大学(University of New Mexico),有机化学,博士后

2012.2-至今:苏州大学医学部药学院,教授

 

二、研究方向

1)抗肿瘤药物和抗抑郁药物研究

2)化学方法学、手性药物研究

3)制药工艺过程研究及杂质研究

 

三、发表论文

 

1)      Sun, W.; Chen, X.; Hu, Y.*; Geng, H.; Jiang, Y.; Zhou, Y.; Zhu, W.; Hu, M.; Hu, H.; Wang, X.; Wang, X.; Zhang, S.*; Hu, Y.* “A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamidesTetrahedron Lett.2020, 61(43), 152442.

2)      Chen, X.; Jiang, Y.; Geng, H.; Liu, X.; Huang, Y.; Lu, J.; Gao, C.; Zhang, S.*; Zhang, J.*; Wang, W.* “Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused OxepanesAdv. Synth. Catal.,2020, 362(13), 2620-2625.

3)      Yu, J.; Chen, X.; Liu, Y.; Wu, B.; Li, H.; Hu, Y.*; Wang, L.*; Zhang, S.*. “Facile Construction of Troponoid Derivatives Incorporating with Imidazolin-2-one MoietiesSynthesis, 2020, 52(12), 1847-1854.

4)      Geng, H.; Chen, X.*; Gui, J.; Zhang, Y.; Shen, Z.; Qian, P.; Chen, J.; Zhang, S.*; Wang, W.* “Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC CatalysisNature Catalysis2019, 2(12), 1071-1077.

5)      Jiang, J.; Cai, X.; Hu, Y.; Liu, X.; Chen, X.; Wang, S.; Zhang, Y.; Zhang, S.* “Thermo-promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols and Malononitrile under Catalyst-free ConditionsJ. Org. Chem. 2019, 84 (4), 2022-2031.

6)      Liu, Y.; Mao, Y.; Hu, Y.; Gui, J.; Wang, L.; Wang, W.;Zhang, S.* “The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl CompoundsAdv. Synth. Catal.,2019, 361, DOI:10.1002/adsc.201801676.

7)      Mao, Y.; Liu, Y.; Hu, Y.; Wang, L.; Zhang, S.;* Wang, W. “Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium HydrideACS catal., 2018, 8, 3016-3020.

8)      Jiang, J.; Hu, Y.; Cai, X.; Wang, L.; Hu, Y.; Chen, S.; Zhang, S.; Zhang, Y. “Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migrationOrg. Biomol. Chem., 2018,16, accepted.

9)      Yang, J.; Qiu, G.; Jiang, J.; Hu, Y.;* Chen, S.; Zhang, S.;* Zhang Y. “Asymmetric Organocatalytic Synthesis of Benzopyran- andBenzofuran-Fused Polycyclic AcetalsAdv. Synth. Catal.,2017, 359, 2184-2190.

10)  Qian, P; Wan, H; Jiang, J; Hu, Y; Chen, X;*Zhang S.-L.;*Discovery of a Special Intramolecular Aldol-Like Reaction in the Synthesis of Related Substance E of TadalafilChin. J. Org. Chem. 2016, 36, 1878-1882.

11)  Xie, R.; Hu, Y.; Wan, H.; Hu, Y.; Chen, S.; Zhang, S.;* Zhang, Y.An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acyetylene amineTetrahedron Lett.2016, 57, 2418-2421.

12)  Chen, X.; Zhang, Y.; Wan, H.; Wang, W.; Zhang, S.* “Stereoselective organocatalytic oxidation of alcohols to enals: a homologation method to prepare polyenes” Chem. Commun., 2016,3532-3535.

13)  Wang, J.; Qian, P.; Hu, Y.; Yang, J.; Jiang, J.; Chen, S.; Zhang, Y.; Zhang, S.* “Organocatalytic aldol addition reaction of cyclic hemiacetals to aldehydesTetrahedron Lett.2015, 56, 2875-2877.

14)  Liu, S.; Hu, Y.; Qian, P.; Hu, Y.; Ao, G.; Chen, S.; Zhang, S.;* Zhang, Y.An efficient cascade approach to dibenzoxazepinones via nucleophilic aromatic substitution and Smiles rearrangementTetrahedron Lett.2015, 56, 2211-2213.

15)  Liu, S.; Zhu, S.; Wu, Y.; Gao, J.; Qian, P.; Hu, Y.; Shi, L.; Chen, S.;Zhang, S.;*Zhang, Y.One-pot synthesis of N-aryl-nicotinamides and diaryl-amines based on a tunable Smiles rearrangementEur. J. Org. Chem., 2015, 3048-3052.

16)  Zhu, Y.; Qian, P.; Yang, J.; Chen,S.; Hu, Y.; Wu, P.; Wang, W.; Zhang, W.; Zhang, S.* “Organocatalytic Enantioselective Michael Addition of Cyclic Hemiacetals to Nitroolefins: A Facile Access to Chiral Substituted 5- and 6-Membered Cyclic EthersOrg. Biomol. Chem., 2015,13, 4769-4775.

17)  Liu, S.; Chen, X.; Hu, Y.; Yuan, L.; Chen, S.; Wu, P.; Wang, W.; Zhang, S.;* Zhang W. “An Efficient Method for the Production of Terminal Alkynes from 1,1-Dibromo-1-alkenes and its Application in the Total Synthesis of Natural Product DihydroxerulinAdv. Synth. Catal.,2015, 357, 553-560.