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许国强

发布者:金雪明发布时间:2018-12-04浏览次数:477

姓  名:许国强

职称职务:特聘教授

联系电话:0512-65882723(办公室),0512-65882370(办公室)

电子邮箱:gux2002@suda.edu.cn

办公地址:苏州大学独墅湖校区二期云轩楼1328


学习经历:

1991.8-1996.7复旦大学,本科(包括一年军训)

1996.8-1999.7复旦大学,理学硕士

1999.8-2002.12美国OhioAkron大学理学博士


研究经历:

2003.1-2005.12美国纽约州康奈尔大学化学和化学生物系,博士后

2006.1-2011.7   美国纽约市康奈尔大学Weill医学院药理学系,博士后

2011.7-2013.2        美国纽约市康奈尔大学Weill医学院药理学系,助理研究教授

2013.2-至今苏州大学特聘教授、医学部药学院博士生导师


主要研究方向:

  • 蛋白质组学

  • 蛋白质翻译后修饰

  • 疾病发生发展机制

 

主要研究成果:

主要从事蛋白质组学、蛋白质泛素化和类泛素化修饰及其功能的研究,探索翻译后修饰在肿瘤发生发展、神经发育等过程中的作用。在Nat CommunJ Biol ChemHum Mol GenetCell Death DisFASEB JJ Proteome ResProteomicsJ ProteomicsBiochem JFEBS JNat Biotechnol等杂志上发表80多篇学术论文。


代表性论文:

  1. Zhou L, Xu G*. Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53. Cell Death Dis, 2019, 10, 69.

  2. Ullah K, Zubia E, Narayan M, Yang J, Xu G*. Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset. FEBS J.2018, doi: 10.1111/febs.14708. [Epub ahead of print]

  3. Chen S, Yang J, Yang L, Zhang Y, Zhou L, Liu Q, Duan C, Mieres CA, Zhou G*, Xu G*. Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells. FEBS J.2018, 285, 2987-3001 (*: co-corresponding authors, Editor’s Choice).

  4. Chen S#, Yang J#, Zhang Y, Duan C, Liu Q, Huang Z, Xu Y, Zhou L*, Xu G*. Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. J. Biol. Chem.2018, 293, 11296-11309 (#: co-first authors; *: co-corresponding authors, Cover Story).

  5. Yang J#, Huang M#, Zhou L, He X, Jiang X, Zhang Y, Xu G*. Cereblon suppresses lipopolysaccharide-induced inflammatory response through promoting the ubiquitination and degradation of c-Jun. J. Biol. Chem.2018, 293, 10141-10157 (#: co-first authors).

  6. Xiong L#, Yan W#, Zubia E#, Zhou Y, Zhang Y, Duan Q, Narayan M, Xu G*. Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12. J. Proteomics. 2018, 182, 34-44. (#: co-first authors).

  7. Zhang Y#, Duan C#, Yang J, Chen S, Liu Q, Zhou L, Huang Z, Xu Y, Xu G*.Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1. Biochem. J. 2018, 475, 1507-1522. (#: co-first authors).

  8. Zhu Y#, Lei Q#, Li D, Zhang Y, Jiang X, Hu Z, Xu G*. Proteomic and biochemical analyses reveal a novel mechanism for promoting protein ubiquitination and degradation by UFBP1, a key component of ufmylation. J. Proteome Res.2018, 17, 1509-1520. (#: co-first authors).

  9. Zhou L, Hao Z, Wang G, Xu G*. Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner. Hum. Mol. Genet. 2018, 27, 667-678.

  10. Wang C, Li J, Takemaru KI, Jiang X, Xu G, Wang B*. Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development2018, 145, dev164236.

  11. Zhou Y, Xiong L, Zhang Y, Yu R, Jiang X, Xu G*. Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells. J. Proteomics2016, 148, 94-104.

  12. Duan W, Chen S, Zhang Y, Li D, Wang R, Chen S, Li J, Qiu X, Xu G*. Protein C-terminal enzymatic labeling identifies novel caspase cleavages during the apoptosis of multiple myeloma cells induced by kinase inhibition. Proteomics2016, 16, 60-69.

  13. Liu Y, Huang X, He X, Zhou Y, Jiang X, Chen-Kiang S, Jaffrey SR,* Xu G*. A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. FASEB J.2015, 29, 4829-4839.

  14. Liu Y, He X, Sui Y, Yu R, Xu G*. Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition. FEBS Lett.2015, 589, 2233-2240.

  15. Deglincerti A, Liu Y, Colak D, Hengst U, Xu G*, Jaffrey SR*. Coupled local translation and degradation regulate growth cone collapse. Nat. Commun.2015, 6, 6888. doi: 10.1038/ncomms7888.

  16. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum. Mol. Genet.2015, 24, 2426-2441.

  17. Xu G*, Jiang X, Jaffrey SR*. A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. J. Biol. Chem.2013, 288, 29573-29585.

  18. Xu G, Jaffrey SR*. The new landscape of protein ubiquitination. Nat. Biotechnol. (News & Views) 2011, 29, 1098-1100.

  19. Xu G, Paige JS, Jaffrey SR*. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat. Biotechnol.2010, 28, 868-873.

  20. Xu G, Shin SY, Jaffrey SR*. Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.Proc. Natl. Acad. Sci. U.S.A.2009, 106, 19310-19315.


授权专利:

Guoqiang Xu (许国强), Jaffrey, S. R. Antibodies for ubiquitinated proteins, 美国发明专利,专利号:US 9,868,781 B2,批准日期:2018.1.16


主持和参与科研项目:

  1. 国家自然科学基金(面上项目):泛素连接酶底物受体cereblon及其突变体调控神经发育机制的研究/316708332017-2020

  2. 国家自然科学基金(面上项目):ADAM12的水解功能在小细胞肺癌增殖和转移中的分子机制研究/314707722015-2018

  3. 国家自然科学基金(面上项目):来那度胺治疗多发性骨髓瘤的分子机制研究/312708742013-2016

  4. 国家重大科学研究计划(973计划)子课题,2012CB947602,生物钟对下丘脑GnRH网络的调控,2014-2016(参与)

  5.  人力资源和社会保障部高层次留学人才回国资助项目


入选人才计划:

2013江苏省高层次创新创业人才(双创计划

2013人社部高层次留学人才回国资助

2014江苏省双创计划团队核心成员

2018江苏省六大人才高峰高层次人才



学术任职:

  1. BMC GenomicsAssociate Editor

  2. 江苏省药理学会,理事

  3. 中国神经科学学会儿童认知与障碍分委会,理事

4