苏州大学药学院欢迎您!

何慧

发布者:金雪明发布时间:2018-12-04浏览次数:2476

姓名:何慧

职称职务:教授

电子邮箱:hhe@suda.edu.cn

办公地址:云轩楼1329

个人简介:

一、学习工作经历

1. 学历背景:

1998.09-2002.07 江西师范大学化学系,学士

2002.09-2005.09 厦门大学化学系,硕士

2007.08-2010.09 香港中文大学化学系,博士

2. 工作经历:

2005.09-2007.07 福建出入境检验检疫局(莆田局),助理工程师

2012.04-2013.08 香港中文大学化学系,博士后

2013.08-至今 苏州大学药学院,副教授教授

二、研究方向

1.光敏药物的设计合成

2. 肿瘤光动力与光热治疗研究

三、主要研究成果

近年来发表SCI论文二十篇。主持国家自然科学基金、江苏省自然科学基金、江苏省高校自然科学基金及苏州市民生科技项目共五项。

1.学术论文

1Zhang,Y.; Shi, M.; Yan, Z.; Zhang, S.; Wang, M.; Xu, H.; Li, H.; Ying, Y.; Qiu, S.; Liu, J.*; Yang, H.; Chen, H.; He, H.*; Guo, Z.* Ultrastable near-infrared nonlinear organic chromophorenanoparticles with intramolecular charge transfer fordually photoinduced tumor ablation. Adv. Healthcare Mater. 2020, DOI: 10.1002/adhm.202001042.

2Yan, Z.; Wang, M.; Shi, M.; He, Y.; Zhang,Y.; Qiu, S.; Yang, H.; Chen, H.; He, H.*; Guo, Z.* Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy.J. Mater. Chem. B 2020, 8, 6886-6897.

3Ye, S.; Rao, J.; Qiu, S.; Zhao, J.; He, H.*; Yan, Z.; Yang, T.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.*; Chen, H.* Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy. Adv. Mater. 2018, 1801216.

4He, H.#; Ji, S.#; He, Y.; Zhu, A.; Zou, Y.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.; Chen, H. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-Induced cancer therapy. Adv. Mater. 2017,29, 1606690.

5Guo, Z.#;Zou, Y.#;He, H.#; Rao, J.; Ji, S.; Cui, X.; Ke, H.; Deng, Y.; Yang, H.; Chen, C.; Zhao, Y.; Chen, H.Bifunctional platinated nanoparticles for photoinduced tumor ablation. Adv. Mater.2016, 28, 10155-10164.

6He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. Chem. Eur. J. 2014, 20, 6241-6245.

7He, H.; Ng, D. K. P. Differential detection of Zn2+ and Cd2+ ions by BODIPY-based fluorescent sensors. Chem. Asian J. 2013, 8, 1441-1446.

8He, H.; Liu, J.-Y.; Ng, D. K. P. A phthalocyanine-based fluorescent sensor for Zn2+ ion. J. Porphyr. Phthalocya.2013,17, 99-103.

9He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis and in vitro photodynamic activities of pegylated distyryl BODIPY derivatives. J. Med. Chem.2011, 54, 3097-3102.

(10He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties. Chem. Commun. 2011, 47, 4748-4750.

11He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY. Org. Biomol. Chem. 2011, 9, 2610-2613.

12Luo, H.; Wang, Q.; Deng, Y.; Yang, T.; Ke, H.; Yang, H.; He,H.;Guo, Z.; Yu, D.; Wu, H.; Chen, H. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy. Adv. Funct. Mater.2017, 27, 1702834.

13Deng, Y.; Huang, L.; Yang, H.; Ke, H.; He,H.; Guo, Z.; Yang, T.; Zhu, A.; Wu, H.; Chen, H. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy. Small2017, 13, 1602747.

14Yan, X.; Yu, Y.; Ji, P.; He,H.; Qiao, C. Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation. Eur.J. Med. Chem.2015, 102, 180-187.

15Zhu, A.; Miao, K.; Deng, Y.; Ke, H.; He,H.; Yang, T.; Guo, M.; Li, Y.; Guo, Z.; Wang, Y.; Yang, X.; Zhao, Y.; Chen, H. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano 2015, 9, 7874-7885.

16Guo, M.; Huang, J.; Deng, Y.; Shen, H.; Ma, Y.; Zhang, M.; Zhu, A.; Li, Y.; He,H.; Wang, Y.; Yang, X.; Zhang, Z.; Chen, H. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced thotothermal therapy. Adv. Funct. Mater.2015, 25, 59-67.

17Guo, M.; Mao, H.; Li, Y.;Zhu, A.;He,H.;Yang, H.;Wang, Y.; Tian, X.; Ge, C.; Peng, Q.; Wang, X.; Yang, X.; Chen, X.; Liu, G.; Chen, H. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials2014, 35, 4656-4666.

18Wan, Z.; Mao, H.; Guo, M.; Li, Y.;Zhu, A.;Yang, H.;He,H.; Shen, J.; Zhou, L.; Jiang, Z.; Ge, C.; Chen, X.; Yang, X.; Liu, G.; Chen, H. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics 2014, 4, 399-411.

19Li, A.; He, H.; Ruan, Y.; Wen, Z.-C.; Zhao, J.-S.; Jiang, Q.-J.; Jiang, Y.-B. Oxidative cyclization of N-acylhydrazones. development of highly selectiveturn-on fluorescent chemodosimeters for Cu2+. Org. Biomol. Chem. 2009, 7, 193-200.

20Wen, Z.-C.; Yang, R.; He, H.;Jiang, Y.-B. A highly selective charge transfer fluoroionophore for Cu2+. Chem. Commun.2006, 106-108.

2.科研与人才项目:

1国家自然科学基金面上项目“自携氧近红外纳米光敏剂的构建及肿瘤协同治疗应用”(31971298),2020-2023主持

2苏州市民生科技项目(医疗卫生应用基础研究)自携氧近红外光敏剂的设计合成及其抗肿瘤活性研究”(sys2018020),2018-2021主持

3国家自然科学基金青年科学基金项目“pH可激活型肿瘤靶向性光敏剂的设计合成及其光动力活性研究”(81402779),2015-2017主持

4江苏省自然科学基金青年科学基金项目“靶向性可激活双功能型光敏剂在肿瘤成像与光动力治疗中的应用”(BK20140369),2015-2017主持

5江苏省高校自然科学基金面上项目“肿瘤靶向性氟硼二吡咯类光敏剂的合成及光动力活性研究”(14KJB350004),2014-2016,主持

6江苏省“双创博士”,2014

7苏州市高等院校、科研院所紧缺高层次人才,2014