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阮建清

发布者:黄小波发布时间:2018-12-04浏览次数:41

 

阮建清.JPG

阮建清

苏州大学,药学院,副教授

江苏省高层次创新创业人才

学历:香港中文大学博士

电子邮箱:ruanjianqing@suda.edu.cn

办公地址:云轩楼1130

研究方向:

1.肝细胞内药物代谢转运研究

2.药物的一期临床研究

3.药物吸收、分布、代谢、排泄以及体内DMPK机制研究

  

科研与学术工作经历:

1.2014/9-至今,苏州大学,药学院,副教授

2.2013/9-2014/8,香港中文大学,博士后

主持科研项目(课题):

1. 国家自然科学基金青年科学基金项目,81703596,不同糖基侧链的黄酮苷对OATP转运功能调节的机制研究,2018/01-2020/1220.2万元,在研,主持

2. 江苏省自然科学基金-青年基金,BK20150349,大黄有机酸成分代谢活化与药物转运体的相互作用研究, 2015/07-2018/0620万元,结题,主持

代表性研究成果

1. 第一作者与通讯作者论文

(1) Yang Mengbi(#), Ruan Jianqing(#), Gao Hong, Li Na, Ma Jiang, Xue Junyi, Ye Yang, Fu Peter Pi-Cheng, Wang Jiyao, Lin Ge(*).First evidence of pyrrolizidine alkaloid Noxideinduced hepatic sinusoidal obstruction syndrome in humans. Arch Toxicol, 2017.12, 9112):3913~3925(共一)(影响因子5.779

(2) Ruan, Jian-QingLi, ShangLi, Ya-PingWu, Wen-JinLee, Simon Ming-YuenYan, Ru(*)The Presystemic Interplay between Gut Microbiota and Orally Administered Calycosin-7-O-beta-D-Glucoside.Drug Metab Dispos2015.10.014310):1601~1611 (影响因子3.615

(3) Ruan, Jianqing(#)Gao, Hong(#)Li, NaXue, JunyiChen, JieKe, ChangqiangYe, YangFu, Peter Pi-ChengZheng, JiangWang, JiyaoLin,Ge(*)Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev2015.10.2334):404~421 (影响因子4.235

(4) Ruan, JianqingYang, MengbiFu, PeterYe, YangLin, Ge(*)Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.Chemical Research in Toxicology2014.6.16276):1030~1039 (影响因子3.867

(5) Ruan, JianqingLiao, CangsongYe, YangLin, Ge(*)Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids.Chemical Research in Toxicology2014.1.21271):7~16(影响因子3.867

(6) Ruan, Jian-QingYan, Ru(*)Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases.Chem Biol Interact2014.9.5220231~240(影响因子3.308

(7) Ruan, JianqingLi, NaXia, QingsuFu, Peter PPeng, ShuyingYe,YangLin, Ge(*)Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis.Journal of Mass Spectrometry2012.3.01473):331~337 (影响因子2.188)

(8) Ruan, Jian-QingLeong, Weng-ImYan, Ru(*)Wang, Yi-TaoCharacterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng.Journal of Agricultural and Food Chemistry2010.5.12589):5770~5776 (影响因子3.791

(9) Yuan, Yuan, Yang, Hua, Kong, Linghua, Li, Yuan, Li, Ping, Zhang, Hongjian, Ruan, Jianqing(*).Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters. Chem Biol Interact. 2017. 11.127779~84 通讯作者(影响因子3.308

(10) Yuan, YuanZheng, JiyueWang, MeiyuLi, YuanRuan, Jianqing(*)Zhang, Hongjian(*)Metabolic Activation of Rhein: Insights into the Potential Toxicity Induced by Rhein-Containing Herbs.J Agric Food Chem2016.7.206428):5742~5750通讯作者(影响因子3.791

2. 其它论文

(11) Mengbi Yang, Jianqing Ruan, Peter P.Fu, Ge Lin. Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chem Biol Interact. 2016;243:119-26.

(12) Nan Hu, Mei Mei, Jianqing Ruan, Wenjin Wu, Yitao Wang, Ru Yan. Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs. Drug Metab Pharmacokinet. 2014;29(3):229-36.

(13) Na Li, Qingsu Xia, Jianqing Ruan, Peter P. Fu, Ge Lin. Hepatotoxicity and Tumorigenicity Induced by Metabolic Activation of Pyrrolizidine Alkaloids in Herbs. Curr Drug Metab. 2011;12(9):823-34.

(14) Zhu Lin, Ruan Jianqing, Li Na, Fu PP, Ye Yang, Lin Ge. A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards. Food Chem. 2016;194:1320-8.

(15) Yan-Hong Li, William Chi-Shing Tai, Jun-Yi Xue, Wing-Yan Wong, Cheng Lu, Jian-Qing Ruan, Na Li, Tai-Fung Wan, Wood-Yee Chan, Wen-Luan Wendy Hsiao, and Ge Lin. Chem Res Toxicol. 2015;28(9):1715-27.

(16) Hong Shen, Weng-Im Leung, Jian-Qing Ruan, Song-Lin Li, Jacky Pui-Cheong Lei, Yi-Tao Wang, and Ru Yan. Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. Chin Med. 2013;8(1):22.

(17) Rui-Na Zhou, Yue-Lin Song, Jian-Qing Ruan, Yi-Tao Wang, Ru Yan. Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb. Drug Metab Pharmacokinet. 2012;27(6):586-97.

(18) Mei Mei, Jian-Qing Ruan, Wen-Jin Wu, Rui-Na Zhou, Jacky Pui-Cheong Lei, Hai-Yu Zhao, Ru Yan, and Yi-Tao Wang. In Vitro Pharmacokinetic Characterization of Mulberroside A, the Main Polyhydroxylated Stilbene in Mulberry (Morus alba L.), and Its Bacterial Metabolite Oxyresveratrol in Traditional Oral Use. J Agric Food Chem. 2012;60(9):2299-308.