滕昕辰

特聘副教授

苏州大学药学院

电子邮箱: xcteng@suda.edu.cn

工作经历

10/2013至今

苏州大学，医学部药学院，特聘副教授

教育经历

05/2010 – 09/2013

美国约翰霍普金斯大学，公共卫生学院，分子微生物及免疫学系，博士后

09/2004 – 05/2010

美国约翰霍普金斯大学，医学院，生物化学、细胞与分子生物学系，博士，GPA: 3.9/4.0

09/2001 – 06/2004   

复旦大学，化学系，硕士，GPA: 3.9/4.0

09/1998 – 06/2001

复旦大学，化学系，学士，GPA: 3.8/4.0

奖励

08/2020   第三届江苏省本科高校青年教师教学竞赛二等

12/2015苏州大学第十四届青年教师课堂教学竞赛一等奖

09/2014   苏州市紧缺人才

09/2014   江苏省双创博士

06/2011美国Phi Beta Kappa学会会员

研究项目

感应特定氨基酸信号的新型TORC1调控因子的筛选及机制研究

中国国家自然基金面上项目（31970550, 01/2020-12/2023）

KCTD蛋白对TORC1信号通路的调控机制及对肿瘤生成的影响

中国国家自然基金青年项目（31401197, 01/2015-12/2017）

KCTD11对TORC1信号通路的调控机制研究

江苏省自然基金青年项目（BK20140318, 07/2014-06/2017）

研究成果

科研论文：

Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X* (2019) Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, J Biol Chem. 294, 12921-12932.

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM (2018) KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect, Ann Neurol. 84, 766-780

Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM*, Teng X* (2018) Whi2 is a conserved negative regulator of TORC1 in response to low amino acids, PLoS Genetics. 14, e1007592

Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM (2013) Genome-wide consequences of deleting any single gene, Mol Cell. 52, 485-494.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM (2011) Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential, J Cell Biol.195, 263-76

Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM (2011) Gene-dependent cell death in yeast, Cell Death Dis.2, e188

Ding Z, Teng X, Zheng Q, Ni F, Cai B, Wang Y, Zhou GM, Sun HZ, Tan XS, Huang ZX. (2009) Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor. Biometals. 22, 817-26

Cheng W-C, Teng X, Park HK, Tucker CM, Dunham MJ and Hardwick JM (2008) Fis1-deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ. 15, 1838-1846

Ding ZC, Zheng Q, Cai B, Ni FY, Yu WH,Teng X, Gao Y, Liu F, Chen D, Wang Y, Wu HM, Sun HZ, Zhang MJ, Tan XS, Huang ZX. (2008) Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF). J Inorg Biochem. 102, 1965-72

Ding ZC, Zheng Q, Cai B, Yu WH, Teng X, Wang Y, Zhou GM, Wu HM, Sun HZ, Zhang MJ, Huang ZX. (2007) Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor. J Biol Inorg Chem. 12, 1173-9

Zhao DX, Teng X, Ding Z, Huang ZX. (2007) Expression and purification of ZNF191(243-368) in three expression systems. Chinese Journal of Chemistry. 25, 1739-42

Ding ZC, Teng X, Cai B, Wang H, Zheng Q, Wang Y, Zhou GM, Zhang MJ, Wu HM, Sun HZ, Huang ZX. (2006) Mutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3. Biochem Biophys Res Commun. 349, 674-82

Cai B, Zheng Q, Teng X, Chen D, Wang Y, Wang KQ, Zhou GM, Xie Y, Zhang MJ, Sun HZ, Huang ZX. (2006) The role of Thr5 in human neuron growth inhibitory factor.J Biol Inorg Chem.11, 476-82

Teng X, Zheng Q, Cai B, Ni FY, Xie Y, Sun HZ, Zhang MJ, Huang ZX. (2005)An Insight of S-nitrosylation of human GIF. Chinese Journal of Chemistry.23, 1545-51

Zheng Q, Yang WM, Yu WH, Cai B, Teng X, Xie Y, Sun HZ, Zhang MJ, Huang ZX. (2003) The effect of the EAAEAE insert on the property of human metallothionein-3. Protein Eng. 16, 865-70

Zhou J, Liu Y, Tang L, Teng X, Tang N, Huang ZX. (2003) Interaction of zinc finger ZNF191(243-368) and its I323W and R327W mutants with oligonucleotides by fluorescence spectrum. Science in China. 46, 64-74

综述

Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM* (2019) KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders, CNS Neurosci Ther. 25, 887-902.

Teng X* and Hardwick JM* (2018) Whi2: a new player in amino acid sensing, Curr Genet. 65, 701-709.

Teng X, Yau E, Sing C, Hardwick JM (2018) Whi2 signals low amino acid availability to halt yeast growth and cell death, FEMS Yeast Res. 18, foy095

Teng X* and Hardwick JM* (2015) Cell death in genome evolution, Semin Cell Dev Biol. 39, 3-11

Teng X* and Hardwick JM* (2014) Genome evolution in yeast reveals connections between rare mutations in human cancers, Microb Cell. 1, 206-209

Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM and White K (2010) Mitochondrial involvement in cell death of non-mammalian eukaryotes, Biochim Biophys Acta. 1813, 597-607  

Teng X and Hardwick JM (2010) The apoptosome at high resolution, Cell. 141, 404-406

书籍章节

Teng X and Hardwick JM (2013) The extrinsic cell death pathway, Molecular Oncology. 353-366

Teng X and Hardwick JM (2013) Quantification of genetically controlled cell death in budding yeast, Methods Mol Biol.1004, 161-70

Teng X and Hardwick JM (2009) Reliable method for detection of programmed cell death in yeast, Methods Mol Biol. 552, 335-342

会议报告：

Teng X (Jun. 2014) Invited speaker. Knockout-driven genome evolution and new insights into amino acid signaling pathway. International Symposium of Mycology, Dalian, Liaoning Province, China

Teng X (Jul. 2010) Invited speaker. Pervasive genetic diversity in the YKO collection reflects gene-specific pressures. Yeast Genetics and Molecular Biology Meeting, University of British Columbia, Vancouver, Canada

Teng X (Oct. 2009) Invited speaker. Evolution of cancer-like mutations that alter nutrient sensing in yeast. Cold Spring Harbor Conference on Cell Death, Cold Spring Harbor, New York, USA

Teng X, Cheng W-C, Leach KM and Hardwick JM (Mar. 2009) Keystone Symposia Education Fund Scholarship Winner.Poster presentation. Evolution of cancer-like mutations in yeast. Keystone Symposia on Cell Death Pathways, Whisler, British Columbia, Canada

Teng X, Cheng W-C, Leach KM and Hardwick JM (Jun. 2008) Poster presentation. Searching for tumor suppressor-like genes in yeast. International Cell Death Symposia, Shanghai, China

Teng X and Hardwick JM (Apr. 2007) Poster presentation. Defining Programmed Cell Death in Yeast. Keystone Symposia on Autophagy and Cell Death Pathways, Monterey, California, USA

Teng X, Yu T, and Hardwick JM (Apr. 2006) Poster presentation. Development of a heat shock assay to detect the anti-death function human Bcl-xL in yeast. Keystone Symposia on Autophagy and Cell Death Pathways, Snowbird, Utah, USA

学生项目

莙政学者项目（2014~2015）

校级大学生课外科研项目（2014，2015，2016，2019，2020）

省级大学生创新创业项目（2014~2016 一般项目，2020~2022 重点项目）