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任海刚

发布者:金雪明发布时间:2018-11-04浏览次数:1469


姓    名:任海刚

职称职务:副教授

联系电话:0512-65882527

电子邮箱:rhg@suda.edu.cn

办公地址:云轩楼2407


个人简介:

一、学习工作经历

1、学历背景:

2001.09-2005.07西南科技大学生物工程专业,学士

2005.09-2010.07中国科学技术大学神经生物学博士,博士

2、工作经历:

2010.07~2012.02西南科技大学生命科学与工程学院讲师

2012.03~2013.06苏州大学医学部药学院讲师

2013.07~至今    苏州大学医学部药学院副教授


二、研究方向

1、帕金森病的病理学机制和神经药理学研究

2、神经退行性疾病相关蛋白的功能研究

3、具有神经保护作用的小分子化合物的筛选


三、主要的研究成果

1、通讯或第一(含共同通讯和并列第一)作者论文

[1] X Xu#, R Wang#, Z Hao, G Wang, C Mu, J Ding, W Sun*, H Ren*, DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo,J Cell Physiol, 235 (2020) 869-879.

[2] D.K. Guo#, Y. Zhu#, H.Y. Sun, X.Y. Xu, S. Zhang, Z.B. Hao, G.H. Wang, C.C. Mu, H.G. Ren*, Pharmacological activation of REV-ERBalpha represses LPS-induced microglial activation through the NF-kappaB pathway, Acta Pharmacol Sin, 40 (2019)26-34.

[3] D. Wu#, Z. Hao, H. Ren*, G. Wang*, Loss of VAPB Regulates Autophagy in a Beclin 1-Dependent Manner, Neurosci Bull, 34 (2018) 1037-1046.

[4] D. Guo#, S. Zhang, H. Sun, X. Xu, Z. Hao, C. Mu, X. Xu, G. Wang*, H. Ren*, Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice, J Biol Chem, 293 (2018) 5090-5101.

[5] D. Chen#, Y.P. Li#, Y.X. Yu, T. Zhou, C. Liu, E.K. Fei, F. Gao, C.C. Mu, H.G. Ren*, G.H. Wang*, Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells, Acta Pharmacol Sin, 39 (2018) 597-606.

[6] Y.F. Pei#, H.G. Ren#, L. Liu, X. Li, C. Fang, Y. Huang, W.Z. Hu, W.W. Kong, A.P. Feng, X.Y. You, W. Zhao, H. Shen, Q. Tian, Y.H. Zhang, H.W. Deng*, L. Zhang*, Genomic variants at 20p11 associated with body fat mass in the European population, Obesity (Silver Spring), 25 (2017) 757-764.

[7] K. Fu#, Y. Wang#, D. Guo, G. Wang*, H. Ren*, Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2, Neurosci Bull, 33 (2017) 685-694.

[8] D. Guo#, Z. Ying, H. Wang, D. Chen, F. Gao, H. Ren*, G. Wang*, Regulation of autophagic flux by CHIP, Neurosci Bull, 31 (2015) 469-479.

[9] H. Ren#, K. Fu, C. Mu, X. Zhen, G. Wang*, L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL, Mol Neurodegener, 7 (2012) 40.

[10] H. Ren#, K. Fu, D. Wang, C. Mu, G. Wang*, Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL, J Biol Chem, 286 (2011) 35308-35317.

[11] H. Ren#, K. Fu, C. Mu, B. Li, D. Wang, G. Wang*, DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells, Cancer Lett, 297 (2010) 101-108.

[12] J. Fan#, H. Ren#, E. Fei, N. Jia, Z. Ying, P. Jiang, M. Wu, G. Wang*, Sumoylation is critical for DJ-1 to repress p53 transcriptional activity, FEBS Lett, 582 (2008) 1151-1156.


2、主持课题

[1]国家自然科学基金面上项目:氧化呼吸链蛋白乙酰化修饰紊乱介导的线粒体功能障碍在帕金森病中的作用及机制研究(31970966),58万,2020.1-2023.12

[2]国家自然科学基金面上项目:Omi/HtrA2调控线粒体生物合成参与神经退变的机制研究(31471012),80万,2015.01-2018.12

[3]中国博士后科学基金面上项目:小脑共济失调相关蛋白CHIP调控mTOR信号通路的机制研究(2014M551648),5万,2014-2016

[4]国家自然科学基金青年基金项目:帕金森病相关蛋白DJ-1调控线粒体凋亡通路的机制研究(31100768),22万,2012.01-2014.12