任海刚

姓名：任海刚

职称职务：副教授

联系电话：0512-65882527

电子邮箱：rhg@suda.edu.cn

办公地址：云轩楼2407

个人简介：

一、学习工作经历

1、学历背景：

2001.09-2005.07   西南科技大学生物工程专业，学士

2005.09-2010.07   中国科学技术大学神经生物学博士，博士

2、工作经历：

2010.07~2012.02   西南科技大学生命科学与工程学院讲师

2012.03~2013.06  苏州大学医学部药学院讲师

2013.07~至今苏州大学医学部药学院副教授

二、研究方向

1、帕金森病的病理学机制和神经药理学研究

2、神经退行性疾病相关蛋白的功能研究

三、主要的研究成果

1、通讯或第一（含共同通讯和并列第一）作者论文

[1] D. Wu^#, Z. Hao, H. Ren*, G. Wang*, Loss of VAPB Regulates Autophagy in a Beclin 1-Dependent Manner, Neurosci Bull, 34 (2018) 1037-1046.

[2] D.K. Guo^#, Y. Zhu^#, H.Y. Sun, X.Y. Xu, S. Zhang, Z.B. Hao, G.H. Wang, C.C. Mu, H.G. Ren*, Pharmacological activation of REV-ERBalpha represses LPS-induced microglial activation through the NF-kappaB pathway, Acta Pharmacol Sin, (2018) 10.1038/s41401-018-0064-0.

[3] D. Guo^#, S. Zhang, H. Sun, X. Xu, Z. Hao, C. Mu, X. Xu, G. Wang*, H. Ren*, Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice, J Biol Chem, 293 (2018) 5090-5101.

[4] D. Chen^#, Y.P. Li^#, Y.X. Yu, T. Zhou, C. Liu, E.K. Fei, F. Gao, C.C. Mu, H.G. Ren*, G.H. Wang*, Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells, Acta Pharmacol Sin, 39 (2018) 597-606.

[5] Y.F. Pei^#, H.G. Ren^#, L. Liu, X. Li, C. Fang, Y. Huang, W.Z. Hu, W.W. Kong, A.P. Feng, X.Y. You, W. Zhao, H. Shen, Q. Tian, Y.H. Zhang, H.W. Deng*, L. Zhang*, Genomic variants at 20p11 associated with body fat mass in the European population, Obesity (Silver Spring), 25 (2017) 757-764.

[6] K. Fu^#, Y. Wang^#, D. Guo, G. Wang*, H. Ren*, Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2, Neurosci Bull, 33 (2017) 685-694.

[7] D. Guo^#, Z. Ying, H. Wang, D. Chen, F. Gao, H. Ren*, G. Wang*, Regulation of autophagic flux by CHIP, Neurosci Bull, 31 (2015) 469-479.

[8] H. Ren^#, K. Fu, C. Mu, X. Zhen, G. Wang*, L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL, Mol Neurodegener, 7 (2012) 40.

[9] H. Ren^#, K. Fu, D. Wang, C. Mu, G. Wang*, Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL, J Biol Chem, 286 (2011) 35308-35317.

[10] H. Ren^#, K. Fu, C. Mu, B. Li, D. Wang, G. Wang*, DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells, Cancer Lett, 297 (2010) 101-108.

[11] J. Fan^#, H. Ren^#, E. Fei, N. Jia, Z. Ying, P. Jiang, M. Wu, G. Wang*, Sumoylation is critical for DJ-1 to repress p53 transcriptional activity, FEBS Lett, 582 (2008) 1151-1156.

2、主持课题

[1]国家自然科学基金面上项目：Omi/HtrA2调控线粒体生物合成参与神经退变的机制研究（31471012），80万，2015.01-2018.12

[2]中国博士后科学基金面上项目（2014M551648），5万，2014-2016