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王洪枫

发布者:金雪明发布时间:2018-11-04浏览次数:2291

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王洪枫教授

wanghongfeng@suda.edu.cn

 

研究方向

1. 神经退行性疾病的发病分子机制

2. 泛素相关蛋白在蛋白质和细胞器质量控制中的作用

 

学习经历

2004-2009  中国科学技术大学神经生物学博士

2000-2004  中国科学技术大学生物科学学士

 

科研经历

2020-至今   教授   苏州大学药学院

2013-2020   副教授   苏州大学药学院

2011-2013   博士后   苏州大学药学院/耶鲁大学医学院

2009-2011         博士后   中国科学技术大学生命科学学院

 

代表性论文

1.        Wang M1, Wang H1, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*, Ying Z* (2020). C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis. Aging Cell. 19(4):e13126.

2.        Zhang Z1, Wang N1, Ma Q, Chen Y, Yao L, Zhang L, Li Q, Shi M, Wang H*, Ying Z* (2020). Somatic and germline mutations of the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells. Acta Pharmacol Sin. 41(1):93-100.

3.        Wang H1, Wang N1, Xu D1, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G, Ying Z*(2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis. Autophagy. 16(9):1683-1696.

4.        Wang N1, Ma Q1, Peng P1, Yu Y, Xu S, Wang G, Ying Z*, Wang H* (2020). Autophagy and ubiquitin-proteasome system coordinate to regulate the protein quality control of neurodegenerative disease-associated DCTN1. Neurotox Res. 37(1):48-57.

5.        Chen Y1, Xu S1, Wang N, Ma Q, Peng P, Yu Y, Ying Z*, Wang H* (2019). Dynasore suppresses mTORC1 activity and induces autophagy to regulate the clearance of protein aggregates in neurodegenerative diseases. Neurotox Res. 36(1):108-116.

6.        Mao J, Xia Q, Liu C, Ying Z, Wang H* and Wang G* (2017) A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation. Hum Mol Genet.26(10):1877-1889.

7.        Zhang Z1, Wang H1, Ding Q1, Xing Y1, Xu D1, Xu Z, Zhou T, Qian B, Ji C, Pan X, Zhong A, Ying Z*, Zhou C*, Shi M* (2017). The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB. Biomed Pharmacother. 891055-1060

8.        Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H* and Wang G* (2016) TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy12(4):707–8.

9.        Zhou L1, Wang H1, Ren H, Hu Q, Ying Z* and Wang G* (2015). Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.52(3):1180-9.

10.    Ying Z1Wang H1Wang G*(2013). The ubiquitin proteasome system as a potential target for the treatment ofneurodegenerative diseases.Curr Pharm Des. 19(18):3305-14.

11.    Wang H1, Ying Z1, Wang G*(2012). Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains. J Biol Chem.  287(34):28576-85.

12.    Ying Z, Wang H*, Fan H, Wang G*(2011). The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin.J Biol Chem.  286(23):20835-44.

13.    Wang HJia NFei EWang ZLiu CZhang TFan JWu MChen LNukina NZhou JWang G (2007). p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasomeJ Neurochem. 101(6)1651~1661

 

科研项目

1.国家自然科学基金面上项目,82071274,氨基酸诱导的mTORC1信号通路参与SCA3/MJD发病的作用机制,2021/01-2024/12,在研,主持

2. 国家自然科学基金面上项目,31771117,去泛素化酶ataxin-3对线粒体自噬的调节作用,2018/01-2021/12,在研,主持

3. 国家自然科学基金面上项目,31371072,去泛素化酶Ataxin-3介导线粒体损伤以及参与神经退行性疾病发病的机制,2014/01-2017/12,已结题,主持

4. 国家自然科学基金青年科学基金,31000473Ataxin-3介导的K63位去泛素化促进神经退行性疾病相关蛋白的聚集,2011/01-2013/12,已结题,主持。

5. 中国博士后科学基金面上项目,20090460734,内质网关联降解通路对不同磷酸化形式ataxin-3的降解影响及其机制,2009/8-2011/6, 已结题,主持。

6. 苏州市高等院校、科研院所紧缺高层次人才引进资助,2014年入选