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周亮

发布者:黄小波发布时间:2018-12-03浏览次数:216

姓名:周亮
职称职务:副研究员
电子邮箱:liangzhou@suda.edu.cn
办公地址:云轩楼1330

  

个人简历:
学习经历:

2004.09-2008.07   内蒙古大学,本科

2008.09-2013.07   中国科学技术大学,博士

  

研究经历:

2013.10-2016.03 美国国立卫生研究院, 博士后

2016.08-2019.07  苏州大学助理研究员

2019.07-至今    苏州大学副研究员

  

研究方向:

蛋白质降解和修饰

神经相关疾病的分子机制

  

主要研究成果:
运用分子、细胞、电生理技术研究神经疾病,在Nat. Commun, cell reports,Molecular NeurobiologyNeuroscience等杂志上发表英文论文。

  

代表性论文:

1.Gu X, Mao X, Lussier MP, Hutchison MAZhou L, Hamra FK, Roche KW, Lu W. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neuronsNature Communications7,10873 (2016).

  

2.Gu X, Zhou L, Lu W. An NMDA receptor-dependent mechanism underlies inhibitory synapse development.Cell Reports 14, 471-478 (2016).

  

3.Zhou L, Wang H, Ren H, Hu Q, Ying Z, Wang G. Bcl-2 decreases the affinity of SQSTM1/p62 to Poly-Ubiquitin chains and suppresses the aggregation of misfolded protein in Neurodegenerative disease. Molecular Neurobiology  52, 1180-1189 (2015).

  

4.Zhou L, Wang H, Chen D, Gao F, Ying Z, Wang G. p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine. International Journal of Molecular Sciences15, 14997-15010 (2014).

  

5.Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z, Wang G. Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax. Neuroscience 243, 14-21 (2013).

  

6.Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacologica Sinica  34, 651-656 (2013).

  

7.Wang P, Li B, Zhou L, Fei E, Wang G. The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins. Neuroscience 190, 43-55 (2011).