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贵春山

发布者:黄小波发布时间:2018-12-03浏览次数:21


姓  名:贵春山

职称职务:博士,副教授

电子邮箱:guichunshan@suda.edu.cn

办公地址:苏州市工业园区仁爱路199号云轩楼

个人简介:

一、学习工作经历

19962000 四川大学,获理学学士学位

20002005 中科院上海药物研究所,获理学博士学位

20052010 美国堪萨斯大学医学中心,博士后

2011-现在 苏州大学医学部药学院,副教授

  

二、研究方向

1. 药物转运蛋白结构和功能的研究

2. 药物代谢动力学研究


三、代表性论文

1. Bian J, Jin M, Yue M, Wang M, Zhang H, Gui C. Tryptophan Residue Located at the Middle of Putative Transmembrane Domain 11 Is Critical for the Function of Organic Anion Transporting Polypeptide 2B1. Mol Pharm.2016, 13: 3553-3563.

2. Wen F, Shi M, Bian J, Zhang H, Gui C. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2015, 10: 1-10.

3Shi M, Liu Y, Bian J, Jin M, Gui C. The interactions between natural products and OATP1B1. Acta Pharmaceutica Sinica 2015, 50: 848-853.

4Gui C, Obaidat A, Chaguturu R, Hagenbuch B. Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr. Chem. Genomics 2010, 4: 1-8.

5.. Gui C, Hagenbuch B. Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comp. Biochem. Physiol. 2010, 151: 393-399.

6Gui C, Hagenbuch B. Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci. 2009, 18: 2298-2306.

7Gui C, Wahlgren B, Lushington GH, Hagenbuch B. Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport. Pharmacol. Res. 2009, 60: 50-56.

8Gui C, Hagenbuch B. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry 2008, 47: 9090-9097.

9Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur. J. Pharmacol. 2008, 584: 57-65.

  


  

四、主要荣誉

2008 获美国药理学和实验治疗学会(ASPET)博士后年青科学家奖

2010 获欧洲药理学杂志论文最高引用奖

  

五、社会兼职

国际刊物《European Journal of Pharmacology》、《Journal of Pharmacy & Pharmaceutical Sciences》和《Pharmacology》的审稿人。