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刘艳丽

发布者:金雪明发布时间:2020-08-27浏览次数:5861


名:刘艳丽

职称职务:特聘教授

电子邮箱:ylliu18ATsuda.edu.cn

办公地址:云轩楼1128

一、学习工作经历

1、学历背景:

1999.09-2003.06:辽宁师范大学,生命科学学院,获理学学士学位

2003.09-2008.12:东北师范大学,生命科学学院,获理学博士学位

2、国外学习研究经历:

2012.05-2014.05,多伦多大学,结构基因组中心,访问学者、博士后

2017.04-2017.09,多伦多大学,结构基因组中心,访问教授

3、工作经历:

2009.04-2018.10,华中师范大学,生命科学学院,讲师,副教授

2018.11-至今,  苏州大学,特聘教授,药学院,博士生导师

二、研究方向

Ø  疾病相关蛋白质结构与功能研究

Ø  表观遗传调控相关蛋白质的结构与功能研究

Ø  基于蛋白质结构与功能的小分子药物筛选和设计

三、主要研究成果

主要从事生物大分子结构和功能研究以及基于结构的药物发现,2016年入选湖北省“青年科技晨光计划”,2019年入选江苏省“六大人才高峰”高层次人才。近5年成功解析了40余个表观遗传相关蛋白的晶体结构,并结合其它生物化学、生物物理学和细胞生物学手段研究了相关蛋白的作用和功能。Nat Chem Biol、Nat Commun、Pharmacol Ther、J Med Chem、Cell Chem Biol、J Biol Chem等国际主流期刊发表SCI收录论文40余篇。

1、代表性论文*通信作者,#共同第一作者)

Ø  Renato Ferreira de Freitas#, Yanli Liu#, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al-Awar, Lindsey I. James, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira*, Abdellah Allali-Hassani#*, Discovery of small-molecule antagonists of the PWWP domain of NSD2, J Med Chem, 2021, 64(3):1584-1592.

Ø  Mengmeng Zhang#, Ming Lei#, Su Qin, Aiping Dong, Ally Yang, Yanjun Li, Peter Loppnau, Timothy R. Hughes, Jinrong Min*, Yanli Liu*, Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains, BBA - Gene Regul Mech, 2021, 1864(3):194688.

Ø  Cheng Dong#, Yanli Liu#, Tian-Jie Lyu#, Serap Beldar, Kelsey N. Lamb, Wolfram Tempel, Yanjun Li, Zoey Li, Lindsey I. James, Su Qin*, Yun Wang* and Jinrong Min*, Structural basis for the binding selectivity of human CDY chromodomains, Cell Chem Biol, 2020, 27(7): 827-838.

Ø  Yanli Liu#, Su Qin#, Tsai-Yu Chen#, Ming Lei#, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee* and Jinrong Min*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4, Nat Commun, 2019, 10: 36.

Ø  Yuzhe Zhang#, Ming Lei#, Xiajie Yang, Yue Feng, Yuan Yang, Peter Loppnau, Yanjun Li, Yi Yang, Jinrong Min*, Yanli Liu*, Structural and histone binding studies of the chromo barrel domain of TIP60, FEBS Lett, 2018, 592(7):1221-1232.

Ø  Yanli Liu, Su Qin, Ming Lei, Wolfram Tempel, Yuzhe Zhang, Peter Loppnau, Yanjun Li and Jinrong Min*, Peptide recognition by HP1 chromoshadow domains revisited: plasticity in the pseudosymmetric histone binding site of human HP1, J Biol Chem, 2017, 292(14): 5655-5664.

Ø  Renata Z. Jurkowska#, Su Qin#, Goran Kungulovski, Wolfram Tempel, Yanli Liu, Pavel Bashtrykov, Judith Stiefelmaier, Tomasz P. Jurkowski, Srikanth Kudithipudi, Raluca Tamas, Hong Wu, Ludmila Dombrovski, Peter Loppnau, Richard Reinhardt, Jinrong Min*, & Albert Jeltsch*, H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1, Nat Commun, 2017, 8(1): 2057.

Ø  Yanli Liu, Li Li and Jinrong Min*, Structural biology: HDAC6 finally crystal clear, Nat Chem Biol, 2016, 12(9): 660-661.

Ø  Yanli Liu, Wolfram Tempel, Qi Zhang, Xiao Liang, Peter Loppnau, Su Qin*, and Jinrong Min*, Family-wide characterization of histone binding abilities of human CW domain-containing proteins,J Biol Chem, 2016, 291(17): 9000-9013.

Ø  Yanli Liu#, Johnathan Lau#, Weiguo Li, Wolfram Tempel, Li Li, Aiping Dong, Ashrut Narula, Su Qin*, Jinrong Min*, Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP, Biochem J, 2016, 473(2): 179-187.

Ø  Yanli Liu* and Jinrong Min, Structure and function of histone methylation binding proteins in plants, Biochem J, 2016, 473(12): 1663-1680.

Ø  Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu, Jacqueline L Norris, Stephanie H Cholensky, Wolfram Tempel, Su Qin, Katherine G Huber, Cari Sagum, Karynne Black, Fengling Li, Xi-Ping Huang, Bryan L Roth, Brandi M Baughman, Guillermo Senisterra, Samantha G Pattenden, Masoud Vedadi, Peter J Brown, Mark T Bedford, Jinrong Min, Cheryl H Arrowsmith, Lindsey I James* & Stephen V Frye*,A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1, Nat Chem Biol,2016, 12(3): 180-187.

Ø  Shasha Liu, Xue Wu, Minru Zong, Wolfram Tempel, Peter Loppnau, Yanli Liu*, Structural basis for a novel interaction between TXNIP and Vav2, FEBS Lett, 2016, 590(6): 857-865.

Ø  Weiguo Li#, Anthony Zhao#, Wolfram Tempel, Peter Loppnau, Yanli Liu*, Crystal structure of DPF3b in complex with an acetylated histone peptide, J Struct Biol, 2016, 195(3): 365-372.

Ø  Yanli Liu, Ke Liu, Su Qin, Chao Xu, Jinrong Min*, Epigenetic targets and drug discovery Part 1: histone methylation, Pharmacol Ther, 2014, 143(3): 275-294.

Ø  Su Qin#, Yanli Liu#, Wolfram Tempel, Mohammad S. Eram, Chuanbing Bian, Ke Liu, Guillermo Senisterra, Lissete Crombet, Masoud Vedadi & Jinrong Min*, Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1, Nat Commun, 2014, 5: 3952.

2、科研项目

Ø  国家自然科学基金青年科学基金(31500613):PAF1复合物介导白血病原癌蛋白——MLL融合蛋白定位的分子基础研究,2016/01-2018/1220万元,已结题,主持。

Ø  湖北省自然科学基金(2009CDB234):水通道蛋白AQP3基因敲除小鼠脂肪萎缩发生的机制研究,2009/12-2010/122万元,已结题,主持。

四、主要荣誉和获奖情况

Ø  湖北省“青年科技晨光计划”,2016年,生物化学与分子生物学

Ø  江苏省“六大人才高峰”高层次人才,2019年,生物技术和新医药产业

Ø  “青年科学家论坛”三等奖,生物化学与分子生物学会2019年全国学术会议

五、社会兼职

江苏省生物物理学会(筹)理事;湖北省生物物理学会理事;湖北省实验动物学会理事;中国细胞生物学学会会员;中国生物化学与分子生物学会会员;湖北省晶体学会会员;湖北省生物化学与分子生物学会会员;
Editor: Heliyon (Cell), Current Protein & Peptide Science, Bentham Brand Ambassador
Reviewer: Nature Communications, Structure, BBA-Mol Cell Res, Heliyon (Cell)