报告题目：Study on the application of two-dimensional black phosphorus in the treatment of tumor
报 告 人：耿胜勇 博士（深圳市人民医院）
Shengyong Geng held his PhD in Biomedical Engineering from Shanghai Jiao Tong University (SJTU) in June 2017. His ph.D work in SJTU synthesized a series of azobenzene derivatives and incorporated them into the bilayers of phospholipids to construct photosensitive liposomes for controlled-drug delivery, these smart drug carriers showed potential application to cancer therapy. He also focused on the construction of catanionic vesicles forlight-responsive drug release. Currently, as a Postdoctoral Fellow, he focuses primarily on the development of two-dimensional black phosphorus-based nanodrugs with synergistic effects of photothermo/chemotherapy for overcoming drug resistance in cancer.
Black phosphorus quantum dots are prepared and incorporated into liposomal bilayers to produce a drug delivery system. In vitro experiments demonstrate its good biocompatibility and NIR-light-induced chemo-photothermal anti-tumor efficiency. In addition, the chemotherapeutic effects of black phosphorus nanosheets (BPs) are uncovered. After intravenous injection into mice with the orthotopic liver tumor, BPs passively accumulate in the tumor site at a high concentration and inhibit tumor growth. The tumor weight is much less than that observed from the doxorubicin (DOX)-treated group and the average survival time is extended by at least two months with 100% survival rate after 120 days. And, tail vein injection of BPs into mice suffering from acute myeloid leukemia results in tumor suppression and long survival. These results thus reveal BPs as a type of bioactive anti-cancer agents and provides insights into the application of inorganic nanomaterials in cancer chemotherapy.