邓泮

发布者:金雪明发布时间:2022-02-11浏览次数:4064



 

    名:邓泮

职称职务:教授、博导

电子邮箱:pandeng@suda.edu.cn

办公地址:云轩楼1132

 

一、学习和工作经历

 

2001.09—2005.07 沈阳药科大学药学院,理科基地班,本科

 

2005.08—2008.07 沈阳药科大学药学院,药剂学,硕士

 

2008.08—2011.07 中科院上海药物研究所,药物分析,博士

 

2011.07—2015.05 中科院上海药物研究所,助理研究员/副研究员

 

2015.05—2017.03 美国肯塔基大学Stable Isotope Resolved Metabolomic Center,博士后

 

2017.04—2020.07 美国肯塔基大学Superfund Research Center,博士后

 

2020.08—2021.10 美国肯塔基大学药学院,助理教授

 

2021.11—至今    苏州大学药学院,特聘教授

 

 

二、研究方向

 

1. 创新药物代谢和药动学研究

2. 微生物代谢和功能研究

3. 环境污染物和人体代谢相互作用研究

 

 

三、主要成绩及研究成果

 

负责建立和确证多种药物和生物标志物的LC-MS/MS生物样品分析方法,突破了质谱分析技术的多个难点,拓展了药物动力学和生物标志物研究领域。例如主持与美国辉瑞公司的合作项目,开发核酸类治疗药物的LC-MS/MS生物样品分析技术,方法成功应用于寡核苷酸PF-ODN及其代谢物的药动学分析,填补了国内小核酸类药物生物分析技术的空白。采用液相色谱-Orbitrap质谱、飞行时间质谱、核磁共振结构分析等方法鉴定药物代谢产物结构,主持研究项目包括胺碘酮、阿比朵尔、20(S)-原人参二醇等。

 

针对肠道菌群的营养来源和代谢特点,设计并建立了稳定同位素示踪的代谢研究体系,用于评价肠道菌群的代谢功能;通过高分辨质谱分析,发现链球菌表面多糖的甘油磷酸修饰结构,这对揭示细菌的药物抵抗、开发新抗生素和疫苗具有重要意义;通过多组学与细胞分子生物学技术结合,系统地研究了环境污染物(全氟/多氟烷基物质、多氯联苯)暴露导致的代谢性疾病机理,并针对特异性代谢通路设计干预策略。

 

作为课题负责人,承担国家自然科学基金青年科学基金项目、中科院上海药物研究所新星计划A类项目;担任Superfund Research ProjectCo-Leader;获肯塔基大学Pilot Program Early Career Investigator Award。作为Co-Investigator参与多项NIH资助研究项目,研究细菌代谢以及环境相关的代谢性疾病机制。作为核心成员(第四完成人),参与了“化学创新药物代谢和药动学研究”项目,并获2014年上海药学科技奖一等奖。迄今为止,发表SCI论文四十余篇,其中作为通讯/第一作者在Journal of Medicinal ChemistryJournal of Lipid ResearchAnalytica Chimica ActaChemosphere等国际一流学术期刊中发表论文二十余篇。担任十四五普通高等教育医学类研究生规划教材《现代药物分析》的编委;参编专著《Handbook of Metabolic Pathways of Xenobiotics》以及《Advanced LC-MS applications in bioanalysis》。担任Journal of Nutritional BiochemistryeFood期刊编委。

 

 

代表性论文

1.    Deng P*, Valentino T, Flythe MD, Moseley H, Leachman JR, Morris AJ, Hennig B. Untargeted stable-isotope probing of the gut microbiota metabolome using 13C-labeled dietary fibers. *: Corresponding author. J. Proteome Res. 2021, 20: 2904-2913

2.    Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol. Appl. Pharmacol. 2020, 409: 115301

3.    Deng P, Hoffman JB, Petriello MC, Wang CY, Li XS, Kraemer MP, Morris AJ, Hennig B. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res. 2020, 61:45-53 (Featured on UKNOW https://uknow.uky.edu/research/high-fiber-diet-may-counteract-harmful-health-effects-pollutants)

4.    Deng P, Li X, Petriello MC, Wang C, Morris AJ, Hennig B. Application of metabolomics to characterize environmental pollutant toxicity and disease risks. Rev Environ Health. 2019, 34(3):251-259.

5.    Deng P, Barney J, Petriello MC, Morris AJ, Wahlang B, Hennig B. Hepatic metabolomics reveals that nonalcoholic steatohepatitis increases PCB 126-induced oxidative stress and metabolic dysfunction. Chemosphere. 2019, 217:140-149

6.    Deng P, Higashi RM, Lane AN, Bruntz RC, Sun RC, Ramakrishnam Raju MV, Nantz MH, Qi Z, Fan TW. Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS. Analyst. 2017, 18;143(1):311-322

7.    Xu Y, Li L, Wang YL, Xing J, Zhou L, Zhong DF, Luo XM, Jiang HL, Chen KX, Zheng MY*, Deng P*, and Chen XY*. Aldehyde oxidase mediated metabolism in drug-like molecules: a combined computational and experimental study. J. Med. Chem. 2017; 60(7):2973-2982 *: Corresponding author

8.    Deng P, Zhong DF, Wang X, Dai Y, Zhou L, Leng Y, Chen XY. Analysis of diacylglycerols by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Double bond location and isomers separation. Anal Chim Acta. 2016, 925: 23-33

9.    Guo YB, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva Y, Schwartz C, Lee E, Evers MB, Morris AJ, Liu S, She QB. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by convergent repression of Bim expression. Nat Commun. 2020, 11: 1-16

10.  Edgar RJ, van Hensbergen VP, Ruda A, Turner AG, Deng P, Le Breton Y, El-Sayed NM, Belew AT, McIver KS, McEwan AG, Morris AJ, Lambeau G, Walker MJ, Rush JS, Korotkov KV, Widmalm G, van Sorge NM, Korotkova N. Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nat Chem Biol. 2019, 15(5):463–471

11.  AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K, Tso P, Cassis LA. XX sex chromosome complement promotes atherosclerosis in mice. Nat Commun. 2019;10(1):2631.

12.  Park SY, Yang JS, Li Z, Deng P, Zhu X, Young D, Ericsson M, Andringa RLH, Minnaard AJ, Zhu C, Sun F, Moody DB, Morris AJ, Fan J, Hsu VW. The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol. Nat Commun. 2019;10(1):3409.

13.  Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z3,2, Mahan AL, Higashi RM, Dang CV, Lane AN. De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues. J Biol Chem. 2019, 294(36):13464-13477

14.  Kong F, Pang X, Zhao J, Deng P, Zheng M, Zhong D, Chen X. Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases. Drug Metab Dispos. 2019, 47(3):238-248

15.  Sun RC, Fan TW, Deng P, Higashi RM, Lane AN, Le AT, Scott TL, Sun Q, Warmoes MO, Yang Y. Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nat Commun. 2017;8(1):1646

16.  Rush JS, Edgar RJ, Deng P, Chen J, Zhu H, van Sorge NM, Morris AJ, Korotkov KV, Korotkova N. The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes. J Biol Chem. 2017;292(47):19441-19457.

  

  

课题组热忱欢迎有志从事药物分析相关研究的本科生、硕士研究生和博士研究生到课题组学习工作。有疑问请随时邮件联系pandeng@suda.edu.cn

 

根据课题组发展需要,现拟招收具有药物分析、微生物学、生物信息学相关研究背景的博士后研究人员,具有药物代谢、药物动力学和代谢组学相关经验者优先考虑,待遇优厚。有意者请发简历至pandeng@suda.edu.cn