苏州大学药学院欢迎您!

王雅俊

发布者:金雪明发布时间:2021-02-26浏览次数:15





名:王雅俊

Name: Yajun Wang  

职称:特聘教授

Title: Professor  

电子邮箱yajunw2020@suda.edu.cn

Email: yajunw2020@suda.edu.cn

办公室:云轩楼1343

Office: Room 1343, Yunxuan Building, Pharmaceutical Sciences  

实验室:云轩楼14061410

Lab: Room 1406 and 1410, Yunxuan Building, Pharmaceutical Sciences  



个人简介

INTRODUCTION


一、学习和工作经历ACADEMIC TRAINING & CAREER

1. 教授,苏州大学药学院,2020.11-

Professor, Pharmaceutical Sciences, Soochow University, Suzhou, China, 2020-11 to present  

2. 博士后研究员,加州大学欧文校区药学院,2016.06-2020.09

Postdoctoral fellow, Pharmaceutical Sciences, University of California, Irvine, CA, USA, 2016.06 -2020.09, Advisor: Prof. John C. Chaput

3. 有机化学博士,英属哥伦比亚大学,2010.09-2016.05

Ph. D in Chemistry, University of British Columbia, Vancouver, BC, Canada,  2010.09-2016.05, Advisor: Prof. David M. Perrin  


二、研究方向STATEMENT OF RESEARCH INTEREST

My major interest of research has been focused at the interface of chemical and synthetic biology to develop artificial nucleic acids with ligand binding (aptamers) and catalytic activities (nucleic acid enzymes), aiming to create artificial nucleic acid based tools gaining both bio-stability and diversified functionalities for biotechnology and medicine. Possibly, such molecules would also help advance our understanding of the origins of life. Towards these goals, we work on the following projects in the Wang lab:   

1. Expanding the chemistry of nucleic acid through chemical modification of nucleobase and sugar backbone  

2. Creating biological toolkit that can process artificial genetic materials, including nucleic acid polymerases, kinases, ligases, and so on, to support in vitro SELEX of functional molecules  

3. Developing automated approaches that enable the rapid discovery of nucleic acid aptamers and catalysts to advance the understanding and applications of nucleic acids as functional molecules  

4. Constructing a biorthogonality in vivo, to ultimately take advantage of the metabolism machinery of living organism (e.g. E. coli), for the sustainable biosynthesis of artificial nucleic acid based therapeutic and diagnostic reagents


三、发表文章PUBLICATIONS

1. Yajun Wang#, Kim Nguyen#, Robert C. Spitale, John C. Chaput*. A Biologically Stable DNAzyme that Efficiently Silences Gene Expression in Cells. Nat. Chem., 2021, In press (# co-first author).

2. Kim Nguyen#, Yajun Wang#, Whitney England, John C. Chaput*, Robert C. Spitale*. Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme. J. Am. Chem. Soc.,2021, In revision (# co-first author).

3. Hui Mei, Yajun Wang,Eric J. Yik, John C. Chaput*. Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate. Biopolymers, 2021, 112, e23388.Special issue honoring Eric T. Kool.

4. Yajun Wang,Alexander Vorperian, Mouhamad Shehabat, John C. Chaput*. Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. ChemBioChem, 2020, 21, 1001-1006. Very Important Paper for the special issue themed Xenobiology 2020, and highlighted by ChemistryViews.

5. Yajun Wang, Arlene Ngor, Ali Nikoomanzar, John Chaput*. Evolution of a general RNA-Cleaving FANA enzyme. Nat. Commun. 2018, 9, 5067. Recommended and highlighted by F1000 Prime.

6. Yajun Wang, Erkai Liu, Curtis Lam, David Perrin*. A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover. Chem. Sci., 2018, 9, 1813-1821.

7. Hui Mei, Jen-yu Liao, Randi M. Jimenez, Yajun Wang, Saikat Bala, Cailen McCloskey, Christopher Switze, and John C. Chaput*. Synthesis and evolution of a threose nucleic acid aptamer bearing 7-deaza-7-substituted guanosine residues. J. Am. Chem. Soc., 2018, 140, 17, 5706-5713.

8. Yajun Wang, Nicole Ng, Erkai Liu, Curtis Lam, David Perrin*. Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection. Org. Biomol. Chem., 2017, 15, 610-618.  

9. Hui Mei, Changhua Shi, Randi Jimenez, Yajun Wang, Kardouh, Miramar, John, Chaput*.Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acid Research, 2017, 45(10): 5629–5638.


四、学术奖励FELLOWSHIPS AND SCHOLARSHIPS

1. Life Sciences-Simons Collaboration on the Origins of Life Postdoctoral Fellowship, 2017-2020, Simons Foundation, USA

2. Four Year Doctoral Fellowship, 2010-2014, University of British Columbia, CANADA

3. Gladys Estella Laird Research Fellowship, 2009-2016, University of British Columbia, CANADA

4. Travel Fellowship for RiboClub 2014, RiboClub Society, CANADA


五、科研项目RESEARCH GRANTS

1. Academic Startup, Soochow University, 2021-2025

2. Life Sciences-Simons Collaboration on the Origins of Life, Simons Foundation, New York, USA, 2017-2020, Award ID: 488559


六、实验室岗位JOB OPENINGS

1. 副教授,科研科学家

Associate professor, Research Scientist,

2. 硕士,博士研究生

Graduate students of all levels  

3. 本科生

Undergrads that are interested in research