李盛亮

姓        名：李盛亮

职称职务：教授、博导

研究方向：光学药物与探针、纳米医学

电子邮箱：lishengliang@suda.edu.cn

办公地址：云轩楼2101

一、个人简介：

李盛亮，苏州大学药学院教授，课题组组长，博士生导师。2012-2016年，博士和博士后阶段师从国家纳米科学中心梁兴杰和中国科学院化学研究所王树研究员分别从事纳米医学和生物光子领域研究学习，随后于2016-2021年分别在马萨诸塞州立大学医学院、康奈尔大学休士顿卫理公会研究所以及香港城市大学从事博士后和高级副研究岗位工作。2021年1月加入苏州大学药学院任特聘教授，研究兴趣主要聚焦于纳米生物光子学与纳米医学范畴，通过设计和构建光活性材料体系发展光-热-磁-声性能可转换的新型纳米医药技术，以此实现精准与高效低毒的重大疾病治疗、生物成像和生物活性调控。目前已发表高水平SCI论文70余篇，其中包括以第一或通讯作者在Adv. Mater., Angew. Chem. In. Ed., ACS Nano, ACS Energy Lett., Mater. Horiz., Chem. Mater., Chem. Sci., Biomaterials等国际权威刊物上发表的论文30余篇。论文被引超过2000次，H因子26，多篇被高频引用和知名媒体报道。申请 PCT 国际专利 4项和中国专利 5 项，参与撰写2本纳米材料领域书籍。同时长期担任Angew. Chem. In. Ed., Adv. Mater., ACS Nano, Adv. Funt. Mater., ACS Applied Material & Interface等多种国际专业期刊审稿人。

二、研究方向：

1. 光活性纳米药物与探针：利用合成设计与纳米技术研究近红外π-共轭光功能材料体系，致力于针对恶性肿瘤、微生物和化学生物学问题发展近红外光学治疗药物、近红外二区光学探针、新型光电磁分子探针以及光结合联合治疗（包括免疫、基因以及蛋白抗体治疗）；

2. 新药剂与药物递送应用：针对化学和生物药物临床应用的关键问题，开发包括无载体自组装、超分子组装及药物偶联等新型与高效低毒的药物递送体系，解决癌症和其他重大疾病的用药问题；

3. 智慧型诊疗器件与医疗器械：面向智慧医疗和个性化诊疗新需求，发展新型可操控性给药技术，光电响应性生命体征监测、材料改造型医疗器械等。 

三、招生方向：

本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生到课题组学习工作。招生方向包括药学、化学、材料学、免疫学和生物医学工程等。有疑问请随时邮件联系lishengliang@suda.edu.cn。

四、招聘信息：

根据课题组发展需要，现拟招收2-3名从事先进生物光子与纳米医学的多学科交叉博士后研究人员。待遇优厚，且有机会到国外访学。有意者请发简历至lishengliang@suda.edu.cn。

五、代表性论文：（^†共同第一作者；*通讯作者）

2021年

1. Xiaoxiao Fan, Yirun Li, Zhe Feng, Guoqiao Chen, Jing Zhou, Mubin He, Lan Wu, Shengliang Li,* Jun Qian,* Hui Lin*, Nanoprobes-assisted multi-channel NIR-II fluorescence imaging-guided resection and photothermal ablation of lymph nodes. Adv. Sci.2021, 202003972.（IF: 15.84）

2. Xiaozhen Li,^† Fang Fang,^† Bo Sun, Chao Yin, Yingpeng Wan, Jinfeng Zhang,* Pengfei Sun, Quli Fan, Pengfei Wang, Shengliang Li,* and Chun-Sing Lee*, Near-infrared small molecule coupled with rigidness and flexibility for high-performance multimodal imaging-guided photodynamic and photothermal synergistic therapy. Nanoscale Horiz.2021, 6, 177.（IF: 9.927）

3. Xiao Cui, Shengzhi Dong, Shengliang Li,* Yafang Xiao, Jinfeng Zhang,* Yanhong Liu, Xiangmin Meng, Feng Li,* and Chun-Sing Lee*, Stable π-Radical Nanoparticles as Versatile Photosensitizer for Effective Hypoxia-Overcoming Photodynamic Therapy. Mater. Horiz.2021, 8, 571.（IF: 14.356）

4. Qi Zhao, Zhongming Huang, Yingpeng Wan, Jihua Tan, Chen Cao, Shengliang Li* and Chun-Sing Lee*, Multifunctional oligomer sponge for efficient solar water purification and oil cleanup. J. Mater. Chem. A 2021, 9, 2104.（IF: 10.7）

2020年

1. Shengliang Li,^†Qingyuan Deng,^† Yachao Zhang,^† Xiaozhen Li, Guohua Wen, Xiao Cui, Yingpeng Wan, Yongwei Huang,* Jiaxiong Chen, Zhonghua Liu, Lidai Wang,* and Chun-Sing Lee*, Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in NIR-II Biowindow. Adv. Mater.2020, 32, 2001146. (IF: 25.809）

2. Huan Chen, Shengliang Li,* Min Wu, Kenry, Zhongming Huang, Chun-Sing Lee,* and Bin Liu,* Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria. Angew. Chem. Int. Ed. 2020, 59, 632.（IF: 12.257）

3. Shengliang Li,^† Haoting Chen,^† Haile Liu,^† Qiankun Ni, Yuan Yuan, Cong Mao, Wei Zhang, Xiaodong Zhang, Weisheng Guo*, Chun-Sing Lee*, and Xing-Jie Liang*, In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation. ACS Nano2020, 14, 13681. （IF: 15.804）

4. Shuang Tian, Zhongming Huang, Jihua Tan, Xiao Cui, Yafang Xiao Yingpeng Wan, Xiaozhen Li, Qi Zhao, Shengliang Li,* and Chun-Sing Lee*, Manipulating Interfacial Charge-Transfer Absorption of Co-crystal Absorber for Efficient Solar Seawater Desalination and Water Purification. ACS Energy Lett.2020, 5,2698.（IF: 19.003）

5. Yingpeng Wan,^† Guihong Lu,^† Wei-Chih Wei,^† Yi-Hsuan Huang, Shengliang Li,* Jia-Xiong Chen, Xiao Cui, Ya-Fang Xiao, Xiaozhen Li, Yanhong Liu, Xiang-Min Meng, Hai-Yan Xie, Jinfeng Zhang,* Ken-Tsung Wong,* and Chun-Sing Lee*, Stable Organic Photosensitizer Nanoparticles with Absorption Peak beyond 800 nm and High ROS Yield for Multi-Modality Phototheranostics. ACS Nano2020, 14, 9917.（IF: 13.9）

6. Ya-Fang Xiao,^† Chenyang Xiang,^†Shengliang Li,* Cong Mao, Haoting Chen, Jia-Xiong Chen, Shuang Tian, Xiao Cui, Yingpeng Wan, Zhongming Huang, Xiaozhen Li, Xiao-Hong Zhang, Weisheng Guo* and Chun-Sing Lee.* Single-Photomolecular Nanotheranostics for Synergetic Near-Infrared Fluorescence and Photoacoustic Imaging-Guided Highly Effective Photothermal Ablation. Small 2020, 16, 2002672.（IF: 10.856）

7. Xiao Cui,Qi Zhao,Zhongming Huang, Yafang Xiao, Yingpeng Wan, Shengliang Li,* and Chun-Sing Lee*, Water-Splitting Based and Related Therapeutic Effects: Evolving Concepts, Progress, and Perspectives. Small 2020, 16, 2004551.（IF: 10.273）

8. Zhongming Huang, Shengliang Li,* Xiao Cui, Yingpeng Wan, Yafang Xiao, Shuang Tian, Hui Wang, Xiaozhen Li, Qi Zhao, and Chun-Sing Lee.* Broadband aggregation-independent plasmonic absorber for highly efficient solar steam generation. J. Mater. Chem. A 2020, 8, 10742.（IF: 10.7）

9. Ya-Fang Xiao,^† Jia-Xiong Chen,^†Shengliang Li, * Wen-Wen Tao, Shuang Tian, Kai Wang, Xiao Cui, Zhongming Huang, Xiao-Hong Zhang,* and Chun-Sing Lee.* Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics. Chem. Sci. 2020, 11, 888.（IF: 9.6）

10. Yijian Gao, Qianqian Li, Chunli Li*, Leyi Gao, Huan Chen, Tingting Liu, Yongwei Huang*, Zhonghua Liu, and Shengliang Li* Terselenophene Regioisomer Conjugated Polymer Materials for High-Performance Cancer Phototheranostics. ACS Appl. Mater. Interfaces 2020, 12, 55605.（IF: 8.758）

11. Qi Zhao, Zhongming Huang, Shuang Tian, Xiao Cui, Yingpeng Wan, Xiaozhen Li, Yafang Xiao, Shengliang Li,* Chun-Sing Lee* Superwetting B4C bilayer foam for high cost-performance solar water purification. Mater. Today Energy 2020, 18, 100498.（IF: 5.604）

12. Zhongming Huang, Xiao Cui, Shengliang Li,* Jinchao Wei, Peng Li, Yitao Wang* and Chun-Sing Lee*. Two-dimensional MXene-based materials for photothermal therapy. Nanophotonics 2020, 10.1515/nanoph-2019-0571.（IF: 6.9）

2019年

1. Xiaozhen Li,^† Lu Liu,^†Shengliang Li,* Yingpeng Wan, Jia-Xiong Chen, Shuang Tian, Zhongming Huang, Ya-Fang Xiao, Xiao Cui, Chengyang Xiang, Xiao-hong Zhang, Weisheng Guo,* Xing-Jie Liang, and Chun-Sing Lee.* Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. ACS Nano 2019, 13, 12901.（IF: 13.903）

2. Shengliang Li,^† Qingyuan Deng,^† Xiao Li, Yongwei Huang,* Xiaozhen Li, Fang Liu, Huijuan Wang, Weixia Qing, Zhonghua Liu,* Chun-Sing Lee.* Bis-diketopyrrolopyrrole conjugated polymer nanoparticles as photothermic nanoagonist for specific and synergistic glioblastoma therapy. Biomaterials 2019, 216, 119252.（IF: 10.273）

3. Jinfeng Zhang, Fang Fang, Bin Liu, Ji-Hua Tan, Wen-Cheng Chen, Zelin Zhu, Yi Yuan, Yingpeng Wan, Xiao Cui, Shengliang Li,* Qing-Xiao Tong, Junfang Zhao, Xiangmin Meng, Chun-Sing Lee* Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon Activated Fluorescence Imaging and Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11, 41051.（IF: 8.456）

4. Jia-Xiong Chen, Wen-Wen Tao, Wen-Cheng Chen, Ya-Fang Xiao, Kai Wang,* Chen Cao, Jia Yu, Shengliang Li, Feng-Xia Geng, Chihaya Adachi, Chun-Sing Lee,* Xiao-Hong Zhang.* Angew. Chem. Int. Ed. 2019, 58, 14660. （IF: 12.257,）

2018年以前

1. Yunxia Wang, Shengliang Li,* Pengbo Zhang, Haotian Bai, Liheng Feng, Fengting Lv, Libing Liu,* and Shu Wang* Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells. Adv. Mater.2018, 30: 1705418.（IF: 25.809）

2. Shengliang Li,^† Tao Chen,^† Yunxia Wang, Yanyi Huang,* Kirk S. Schanze,* and Shu Wang*, Conjugated Polymer with Intrinsic Alkyne Units for Synergetically Enhanced Raman Imaging in Living Cells. Angew. Chem. Int. Ed. 2017, 56, 13455. （IF: 12.257）

3. Shengliang Li, Yanhuan Chen, Huibiao Liu, Yunxia Wang, Libing Liu, Fengting Lv, Yuliang Li* and Shu Wang.* Graphdiyne Materials as Nanotransducer for in Vivo Photoacoustic Imaging and Photothermal Therapy of Tumor.Chem. Mater. 2017,29, 6087. （IF: 10.159）

4. Shengliang Li, Xiaoyu Wang, Rong Hu, Hui Chen, Meng Li, Jianwu Wang, Yunxia Wang, Libing Liu, Fengting Lv, Xing-Jie Liang,* and Shu Wang*. Near-infrared (NIR)-absorbing conjugated polymer dots as highly effective photothermal materials for in vivo cancer therapy.Chem. Mater.2016, 28, 8669.（IF: 10.159）

5. Shengliang Li, Huanxiang Yuan, Hui Chen, Xiaoyu Wang, Pengbo Zhang, Fengting Lv, Libing Liu, Shu Wang*. Cationic poly(p-phenylene vinylene) materials as a multifunctional platform for light-enhanced siRNA delivery.Chem Asian J.2016, 11, 2686.（IF: 3.698）

6. Shengliang Li,^† Kelei Hu,^† Yun Sun, Weipeng Cao, Shubin Jin, Wang Sheng, Yan Wu*, Xing-Jie Liang.* pH-responsive biocompatible fluorescent polymer nanoparticles based on phenylboronic acid for intracellular imaging and drug delivery. Nanoscale2015, 6, 13701.（IF: 6.97）

7. Shengliang Li,^† Chunqiu Zhang,^†Weipeng Cao, Benyu Ma, Xiaowei Ma, Shubin Jin, Jinchao Zhang, Paul C. Wang, Feng Li,*Xing-Jie Liang.* Anchoring effects of surface chemistry on gold nanorods: modulates autophagy. J. Mater. Chem. B2015, 3, 3324.（IF: 5.047）

8. Xuemin Zhang,^†Shengliang Li,^† Zhenying Liu, Shu Wang,* and Jinchong Xiao.* Self-assembled multicolor nanoparticles based on functionalized twistacene dendrimer for cell fluorescent imaging. NPG Asia Mater. 2015, 7, e230.（IF: 8.052）

9. Jinfeng Zhang,^†Shengliang Li,^† Fei-Fei An, Juan Liu, Shubin Jin, Jin-Chao Zhang, Paul C. Wang, Xiaohong Zhang,* Chun-Sing Lee* and Xing-Jie Liang.* Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release. Nanoscale 2015, 7, 13503.（IF: 6.97）

10. Keni Yang,^†Shengliang Li,^† Shubin Jin, Xiangdong Xue, Tingbin Zhang, Chunqiu Zhang*, Jing Xu* and Xing-Jie Liang.* Micelle-like luminescent nanoparticles as a visible gene delivery system with reduced toxicity. J. Mater. Chem. B2015, 3, 3324.（IF: 5.047）

11. Shubin Jin,^†Shengliang Li,^† Xizhong Wang, Xi Zhang, Xing-Jie Liang.* Biosafe nanoscale pharmaceutical adjuvant materials. J. Biomed. Nanotechnol.2014, 10, 2393.（IF: 5.068）

12. Shengliang Li,^† Zhonghua Liu,^† Fengtao Ji, Zijian Xiao, Minjuan Wang, Yingji Peng, Yuling Zhang, Ling Liu, Zibing Liang, Feng Li.* Delivery of Quantum Dot-siRNA nanoplexes in SK-N-SH cells for BACE1 gene silencing and intracellular imaging. Mol. Ther. Nucleic Acids2012, 1, e20.（IF: 7.032）

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