贵春山

姓名：贵春山

职称职务：教授，博导

电子邮箱：guichunshan@suda.edu.cn

办公地址：云轩楼1130

一、个人简介

 2000年毕业于四川大学，获学士学位；2005年毕业于中国科学院上海药物研究所，获博士学位；2005-2010年在美国堪萨斯大学医学中心从事博士后研究。2011年12月加入苏州大学药学院，任副教授；2020年7月晋升为教授。

二、研究方向

1. 药物转运体的结构和功能研究

2. 药物转运体的基因多态性研究

3. 转运体介导的药物-药物/食物相互作用研究

4. 化合物临床前ADME及成药性评价

三、代表性论文

1. Wang Z, Li Y, Villanueva CE, Peng T, Han W, Bo Z, Zhang H, Hagenbuch B*, Gui C*. The Importance of Val386 in Transmembrane Domain 8 for the Activation of OATP1B3 by Epigallocatechin Gallate.J Agric Food Chem. 2022, 70: 6552-6560.

2. Wang Z, Li Y, Peng T, Su Y, Luo X, Han W, Zhang H, Ruan J, Gui C*. Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein.ACS Omega 2021, 6: 35844-35851.

3. Liu S, Peng T, Wang Z, Li Y, Zhang H*, Gui C*. Effect of rare coding variants of charged amino acid residues on the function of human organic anion transporting polypeptide 1B3 (SLCO1B3). Biochem Biophys Res Commun. 2021, 557: 1-7.

4. Yang J, Wang Z, Liu S, Wang W*, Zhang H, Gui C*. Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1). Mol Pharm. 2020, 17: 3966-3978.

5. Xiang Y, Liu S, Yang J, Wang Z, Zhang H*, Gui C*. Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis. BBA - Biomembranes 2020, 1862: 183210.

6. Ni Y, Duan Z, Zhou D, Liu S, Wan H, Gui C*, Zhang H*. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020, 11: 802.

7. Zhou D, Xu Y, Wang Y, Li J, Gui C*, Zhang H*. Interaction of Organic Anion Transporter 3-Mediated Uptake of Steviol Acyl Glucuronide, a Major Metabolite of Rebaudioside A, with Selected Drugs. J Agric Food Chem. 2020, 68: 1579-1587.

8. Nie Y, Yang J, Liu S, Sun R, Chen H, Long N, Jiang R, Gui C*. Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics. Xenobiotica 2020, 50: 297-317.

9. Yue M, Yang J, Jin M, Steiert B, Xiang Y, Zhang H, Hagenbuch B, Gui C*. Gly45 and Phe555 in Transmembrane Domains 1 and 10 Are Critical for the Activation of Organic Anion Transporting Polypeptide 1B3 by Epigallocatechin Gallate. J Agric Food Chem. 2019, 67: 9079-9087.

10. Bian J, Jin M, Yue M, Wang M, Zhang H, Gui C*. Tryptophan residue located at the middle of putative transmembrane domain 11 is critical for the function of organic anion transporting polypeptide 2B1. Mol Pharm. 2016, 13: 3553-3563.

11. Wen F, Shi M, Bian J, Zhang H, Gui C*. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016, 54: 293-302.

12. Gui C, Obaidat A, Chaguturu R, Hagenbuch B*. Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics 2010, 4: 1-8.

13. Gui C, Hagenbuch B*. Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comp Biochem Physiol. 2010, 151: 393-399.

14. Gui C, Hagenbuch B*. Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci. 2009, 18: 2298-2306.

15. Gui C, Wahlgren B, Lushington GH, Hagenbuch B*. Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport. Pharmacol Res. 2009, 60: 50-56.

16. Gui C, Hagenbuch B*. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry 2008, 47: 9090-9097.

17. Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B*. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008, 584: 57-65.

18. Gui C, Zhu W*, Chen G, Luo X, Liew OW, Puah CM, Chen K, Jiang H. Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. Proteins 2007, 67: 41-52.

四、主要荣誉

1. 苏州市高等院校、科研院所紧缺高层次人才，2013年

2. 欧洲药理学杂志论文最高引用奖，2010年

3. 美国药理学和实验治疗学会（ASPET）博士后青年科学家奖，2008年