韩亮 副教授
韩亮,博士,特聘副教授,硕士生导师。2012年在复旦大学药学院获药剂学理学博士学位(导师:蒋晨教授);2012年至2015年在美国耶鲁大学医学院从事博士后研究工作,2016年至今在苏州大学药学院工作。主要研究领域为:脑转移瘤靶向治疗药物递送系统。迄今为止,在权威期刊如Advanced Materials, ACS Nano, Small,Biomaterials, Nanomedicine, Advanced Healthcare Materials, Molecular Pharmaceutics等发表论文23篇,其中第一作者10篇;已授权中国发明专利5项,申请美国发明专利1项;获“上海市研究生优秀成果(学位论文)”“科创杯上海高校学生创造发明奖”等。社会兼职:现任Medicine®杂志学术编委。
E-mail: hanliang@suda.edu.cn
研究方向
1、线粒体靶向药物敏感释放系统;
2、脑转移瘤靶向药物递送系统;
课题组成员情况
1. 2016级硕士研究生
郭倩
2012-2016,江苏大学药学院,工学学士;
2016年至今:苏州大学药学院,硕士在读;
主要从事线粒体靶向药物敏感释放系统的研究。
联系方式:20164226010@stu.suda.edu.cn
2. 2017级硕士研究生
缪彤彤
2013-2017:苏州大学药学院,理学学士;
2017年至今:苏州大学药学院,硕士在读;
主要从事脑转移瘤靶向药物递送系统的研究。
联系方式:584183471@qq.com
鞠秀峰
2013-2017:南京中医药大学药学院, 工学学士;
2017年至今:苏州大学药学院,硕士在读
主要从事脑转移瘤靶向药物递送系统的研究。
联系方式:15651666556@163.com
3. 2013级本科生
常增颜
2013年至今:苏州大学药学院,学士在读;
主要从事天然硅藻岩作为抗肿瘤药物靶向递送载体的制剂化研究。
联系方式:1002499964@qq.com
科研成果
期刊文章
1. Liang Han, Qiang Cai, Daofeng Tian, Derek K. Kong, Xingchun Gou, Zeming Chen, Stephen M. Strittmatter, Zuoheng Wang, Kevin N. Sheth, Jiangbing Zhou. Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine, 2016, 12:1833~1842. (中科院JCR大类一区,SCI IF 5.671)
2. Liang Han, Derek K. Kong, Ming-Qiang Zheng, Sasidhar Murikinati, Chao Ma, Peng Yuan, Liyuan Li, Daofeng Tian, Qiang Cai, Chunlin Ye, Daniel Holden, June-Hee Park, Xiaobin Gao, Jean-Leon Thomas, Jaime Grutzendler, Richard E. Carson, Yiyun Huang, Joseph M. Piepmeier, Jiangbing Zhou. Increased nanoparticle delivery to brain tumors by autocatalytic priming for improved treatment and imaging. ACS Nano, 2016, 10:4209~4218. (中科院JCR大类一区,SCI IF 13.334)
3. Liang Han, Mingming Liu, Deyong Ye, Ning Zhang, Ed Lim, Jing Lu, Chen Jiang. Tumor cell membrane-targeting pH-dependent electron donor-acceptor fluorescence systems with low background signals. Biomaterials, 2014, 35:2952~2960. (中科院JCR大类一区,SCI IF 8.387)
4. Liang Han, Yubo Guo, Haojun Ma, Xi He, Yuyang Kuang, Ning Zhang, Ed Lim, Wenjiang Zhou, Chen Jiang. Acid active receptor-specific peptide ligand for in vivo tumor-targeted delivery. Small, 2013, 9:3647~3658. (中科院JCR大类一区,SCI IF 8.315)
5. Liang Han, Haojun Ma, Yubo Guo, Yuyang Kuang, Xi He, Chen Jiang. pH-controlled delivery of nanoparticles into tumor cells. Adv. Healthc. Mater., 2013, 2:1435~1439. (中科院JCR大类一区,SCI IF 5.76)
6. Liang Han, Jianfeng Li, Shixian Huang, Rongqin Huang, Shuhuan Liu, Xing Hu, Peiwei Yi, Dai Shan, Xuxia Wang, Hao Lei, Chen Jiang. Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent. Biomaterials, 2011, 32:2989~2998. (中科院JCR大类一区,SCI IF 8.387)
7. Liang Han, Rongqin Huang, Jianfeng Li, Shuhuan Liu, Shixian Huang, Chen Jiang. Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer. Biomaterials, 2011, 32:1242~1252. (中科院JCR大类一区,SCI IF 8.387)
8. Liang Han, Rongqin Huang, Shuhuan Liu, Shixian Huang, Chen Jiang. Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin receptor overexpressed tumors. Mol. Pharm., 2010, 7:2156~2165. (中科院JCR大类二区,SCI IF 4.342)
9. Rongqin Huang, Liang Han, Jianhua Li, Feiliang Ren, Weilun Ke, Chen Jiang, Yuanying Pei. Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles. J. Gene Med., 2009, 11:754~763. (共同一作,中科院JCR大类三区,SCI IF 4.342)
10. 韩亮, 黄容琴, 蒋晨. 诊断兼治疗的多功能肿瘤靶向纳米递释系统. 国际药学研究杂志, 2011, 38:362~368.
11. Garth Strohbehn, Daniel Coman, Liang Han, Ragy R. T. Ragheb, Tarek M. Fahmy, Anita J. Huttner, Fahmeed Hyder, Joseph M. Piepmeier, Mark W. Saltzman, Jiangbing Zhou. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J. Neurooncol., 2015, 121:441~449. (中科院JCR大类三区,SCI IF 2.754)
12. Rongqin Huang, Haojun Ma, Yubo Guo, Shuhuan Liu, Yuyang Kuang, Kun Shao, Jianfeng Li, Yang Liu, Liang Han, Shixian Huang, Sai An, Liya Ye, Jinning Lou, Chen Jiang. Angiopep-conjugated nanoparticles for targeted long-term gene therapy of parkinson's disease. Pharm. Res., 2013, 30:2549~2559. (中科院JCR大类二区,SCI IF 3.26)
13. Shuhuan Liu, Yubo Guo, Rongqin Huang, Jianfeng Li, Shixian Huang, Yuyang Kuang, Liang Han, Chen Jiang. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials, 2012, 33:4907~4916. (中科院JCR大类一区,SCI IF 8.387)
14. Jianfeng Li, Lu Zhou, Deyong Ye, Shixian Huang, Kun Shao, Rongqin Huang, Liang Han, Yang Liu, Shuhuan Liu, Liya Ye, Jinning Lou, Chen Jiang. Choline-derivate-modified nanoparticles for brain-targeting gene delivery. Adv. Mater., 2011, 23:4516~4520. (中科院JCR大类一区,SCI IF 18.96)
15. Shixian Huang, Jianfeng Li, Liang Han, Shuhuan Liu, Haojun Ma, Rongqin Huang, Chen Jiang. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials, 2011, 32:6832~6838. (中科院JCR大类一区,SCI IF 8.387)
16. Rongqin Huang, Liang Han, Jianfeng Li, Shuhuan Liu, Kun Shao, Yuyang Kuang, Xing Hu, Xuxia Wang, Hao Lei, Chen Jiang. Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. Biomaterials, 2011, 32:5177~5186. (中科院JCR大类一区,SCI IF 8.387)
17. Rongqin Huang, Weilun Ke, Liang Han, Jianfeng Li, Shuhuan Liu, Chen Jiang. Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration. Biomaterials, 2011, 32:2399~2406. (中科院JCR大类一区,SCI IF 8.387)
18. Kun Shao, Rongqin Huang, Jianfeng Li, Liang Han, Liya Ye, Jinning Lou, Chen Jiang. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J. Control. Release, 2010, 147:118~126. (中科院JCR大类一区,SCI IF 7.441)
19. Rongqin Huang, Shuhuan Liu, Kun Shao, Liang Han, Weilun Ke, Yang Liu, Jianfeng Li, Shixian Huang, Chen Jiang. Evaluation and mechanism studies of PEGylated dendrigraft poly-L-lysines as novel gene delivery vectors. Nanotechnology, 2010, 21:265101. (中科院JCR大类二区,SCI IF 3.573)
20. Rongqin Huang, Weilun Ke, Liang Han, Yang Liu, Kun Shao, Chen Jiang, Yuanying Pei. Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo. Brain Res. Bull., 2010, 81:600~604. (中科院JCR大类三区,SCI IF 2.572)
21. Weilun Ke, Kun Shao, Rongqin Huang, Liang Han, Yang Liu, Jianfeng Li, Yuyang Kuang, Liya Ye, Jinning Lou, Chen Jiang. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials, 2009, 30:6976~6985. (中科院JCR大类一区,SCI IF 8.387)
22. Rongqin Huang, Weilun Ke, Liang Han, Yang Liu, Kun Shao, Liya Ye, Jinning Lou, Chen Jiang, Yuanying Pei. Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. J. Cereb. Blood Flow Metab., 2009, 29:1914~1923. (中科院JCR大类二区,SCI IF 4.929)
23. Yang Liu, Rongqin Huang, Liang Han, Weilun Ke, Kun Shao, Liya Ye, Jinning Lou, Chen Jiang. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials, 2009, 30:4195~4202. (中科院JCR大类一区,SCI IF 8.387)
专利
1. 韩亮, 蒋晨. 一种微酸环境靶向多肽修饰的肿瘤靶向纳米给药系统及其制备方法, 中国发明专利, 专利号ZL201210380990.7, 授权公告日2016.01.13
2. 韩亮,蒋晨. 一种微酸环境控制开启的肿瘤主动靶向纳米给药系统及其制备方法,中国发明专利, 专利号ZL201210380988.X, 授权公告日2015.10.07
3. 韩亮, 蒋晨, 黄容琴. 一种肿瘤靶向诊断核磁共振造影剂及其制备方法,中国发明专利, 专利号ZL201010286508.4, 授权公告日2013.05.29
4. 韩亮, 蒋晨, 黄容琴, 柯伟伦. 一种多肽修饰的肝肿瘤靶向纳米给药系统及其制备方法,中国发明专利, 专利号ZL200910198450.5, 授权公告日2013.03.13
5. 蒋晨, 韩亮, 黄容琴. 一种肿瘤靶向基因与化疗药物双载药递释系统及其制备方法,中国发明专利, 专利号ZL201010286479.1, 授权公告日2013.04.10