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钟志远

发布者:金雪明发布时间:2021-04-04浏览次数:10


  钟志远 苏州大学特聘教授,江苏特聘教授,Journal of Controlled Release(影响因子:7.9)副主编,国家杰出青年基金获得者,国家“万人计划”创新领军人才。苏州大学生物医用高分子材料重点实验室主任。1995年吉林工业大学(现吉林大学)获学士学位,1998年中国科学院长春应用化学研究所获硕士学位,2002年荷兰屯特大学获博士学位。2002-2007年荷兰屯特大学任助理教授。2007年4月起受聘为苏州大学特聘教授。2011-2012年担任苏州生物纳米园副总裁。研究领域涉及生物医用高分子材料、纳米药物(化学药物、蛋白质药物、RNA药物)、及肿瘤靶向治疗。在国际主流期刊发表论文240多篇,论文共被引用17000多次,H-因子70,3篇论文入选“中国百篇最具影响国际学术论文”,自2014年起连续入选中国高被引学者榜单(材料科学领域),2018年入选药理学/毒理学领域全球高被引科学家(Highly Cited Researcher,Clarivate Analytics),2019年入选交叉学科全球高被引科学家。申请了50多项国家和国际发明专利(其中授权20多项),11项专利技术已转让。近几年,应邀在重要国际学术会议上做邀请报告50多次。


  2015-2019年担任美国化学会期刊Biomacromolecules(影响因子:5.7)副主编,2019年起担任Journal of Controlled Release(IF 7.9)副主编,担任Materials Today (IF 24.5), Nanotechnology, Acta Pharmaceutica Sinica B, Journal of Gene Medicine, Nano Futures, Journal of Biomaterials Science Polymer Edition, Materials Today Chemistry等国际期刊编委,新型高分子材料与控制释放系列高水平国际学术会议(SIPCD 2010,2012,2014,2016,2018,2020)主席,国家自然科学基金委员会重大项目评审组专家,中国材料研究学会高分子材料与工程分会常务理事等。江苏省教育厅优秀科技创新团队带头人。


  获得了美国化学会的“生物大分子/大分子青年研究者奖”(2014)、德国洪堡基金会“贝塞尔研究奖”(2013)、日本和美国控制释放学会共同颁发的 “亚洲药物释放系统突破技术奖”(2013)等国际奖励。入选国家“万人计划”创新领军人才、国家杰出青年科学基金获得者(杰青结题特优)、国家百千万人才工程并授予“有突出贡献中青年专家”荣誉称号、科技部中青年科技创新领军人才、江苏特聘教授、江苏省333工程第二层次培养对象、苏州市十佳魅力科技人物等。2018年当选美国医学与生物工程院会士(AIMBE Fellow)。享受国务院政府特殊津贴。



学习和工作经历

1991.09—1995.07 吉林工业大学(现吉林大学)应用化学系

1995.09—1998.07 中国科学院长春应用化学研究所硕士生(导师:景遐斌研究员)

1998.10—2002.10 荷兰屯特大学(University of Twente) 博士生(导师:Jan Feijen 教授)

2002.10—2007.04 荷兰屯特大学(University of Twente)生物医学技术研究所及高分子化学和生物材料系助理教授

2004.09—2004.11 美国犹他大学(University of Utah) 药学院 访问学者(Sung Wan Kim教授研究组)

2007.04—至今苏州大学生物医用高分子材料重点实验室苏州大学特聘教授、实验室主任:

2010.12—至今江苏省先进功能高分子材料设计及应用重点实验室副主任


学术和社会兼职

1. 首届新型高分子材料与控制释放国际会议(Symposium on Innovative Polymers for Controlled Delivery, SIPCD 2010, 2010年9月14-17日, 苏州)执行组委会主席.

2. 第二届新型高分子材料与控制释放国际会议(2 Symposium on Innovative Polymers for Controlled Delivery, SIPCD 2012, 2012年9月11-14日, 苏州)执行组委会主席.

3. 第三届新型高分子材料与控制释放国际会议(3 Symposium on Innovative Polymers for Controlled Delivery, SIPCD 2014, 2014年9月16-19日, 苏州)执行组委会主席

4.美国材料化学学会2013年春季年会“Multifunctional Biomaterials” Symposium (MRS Spring 2013 Meeting, April 1-5, 2013, San Francisco, USA)共同主席.

5.Journal of Controlled Release客座主编((J. Control. Release, Volume 152, Issue 1, 30 May 2011).

6.Journal of Controlled Release客座主编(J. Control. Release, Volume 169, Issue 3, 10 August 2013).

7. 美国化学会期刊Biomacromolecules编委(2011.1-).

8. Elsevier期刊Journal of Controlled Release编委(2012.5-).

9.Journal of Biomaterials Science, Polymer Edition编委(2012.8-).

10. 英国皇家化学会期刊Journal of Materials Chemistry B顾问(2014.1-).

11. 《中国科学-化学》英文刊SCIENCE CHINA Chemistry (Springer)青年工作委员会委员(2014.3-).

12.《药学学报》英文刊Acta Pharmaceutica Sinica B (Elsevier)编委(2014.7-).

13.国家自然科学基金委员会专家评审组专家(2012-)。

14.德国亥姆霍兹国家究中心生物材料研究所洪堡客座教授(2013 - 2015)

15.柏林自由大学洪堡客座教授(2013 - 2015)

16.中国材料研究学会高分子材料与工程分会常务理事(2014.7-)

17.江苏省青年联合会第十和第十一届委员会委员


论文发表

1) Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, and Z.Y. Zhong*, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014 (in revision)

2) W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates and Copolymers, J. Control. Release 2014, http://dx.doi.org/10.1016/j.jconrel.2014.05.023.

3) Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy, Biomacromolecules 2014, 15, 1955-1969.

4) Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H.Y.Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, http://dx.doi.org/10.1016/j.jconrel.2014.05.016

5) Y.J. Jiang, J. Chen, C. Deng*, E. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials 2014, 35, 4969-4985.

6) C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39, 330-364.

7) W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules 2014, 15, 900-907.

8) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis, Acta Biomaterialia 2014, 10, 2159-2168

9) F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, and Z.Y. Zhong*, pH-sensitive polymer nanoparticles for tumor-targeting doxorubicin delivery: Concept and recent advances, Nanomedicine 2014, 9, 487-499. (invited review)

10) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, doi:10.1089/ars.2013.5733 (invited forum article)

11) W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity, Chinese Journal of Chemistry 2014, 32, 57-65.

12) Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules 2013, 14, 3723-3730.

13) J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules 2013, 46, 6723–6730.

14) Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry, Biomacromolecules 2013, 14, 2814-2821.

15) X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells, Biomacromolecules 2013, 14, 2873-2882.

16) Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules 2013, 14, 2772-2780.

17) Y.N. Zhong, W. Wang, L. Cheng, F.H. Meng, Z.Y. Zhong*, and Z. Liu*, Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells, Biomacromolecules 2013, 14, 2411-2419.

18) L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions,Biomaterials 2013, 34, 5262-5272.

19) W. Chen, M. Zheng, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins, Biomacromolecules 2013, 14, 1214-1222.

20) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opin. Drug Deliv. 2013, 10, 1109-1122.

21) R. Cheng, F.H. Meng, C. Deng, H.A. Klok, and Z.Y. Zhong*, Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery, Biomaterials 2013, 34, 3647-3657.

22) J. Feijen, and Z.Y. Zhong*, The Second Symposium on Innovative Polymers for Controlled Delivery, September 11-14, 2012, Suzhou, China, J. Control. Release 2013, 169, 163-164.

23) W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171-179.

24) J. Feijen, W.E. Hennink‌, and Z.Y. Zhong*, Conference Scene: From Innovative Polymers To Advanced Nanomedicine: Key Challenges, Recent Progress and Future Perspectives, Nanomedicine 2013, 8, 177-180.

25) W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Functional Poly(ε-caprolactone)s via Copolymerization of ε‑Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules 2013, 46, 699-707.

26) F.H. Meng, R. Cheng, C. Deng, and Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Materials Today 2012, 15, 436-442 (invited review)

27) Y.L. Wu, W. Chen, F.H. Meng, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Core-Crosslinked pH-Sensitive Degradable Micelles: A Promising Approach to Resolve the Extracellular Stability Versus Intracellular Drug Release Dilemma, J. Control. Release 2012, 164, 338-345.

28) C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects, Nano Today 2012, 7, 467-480 (invited review)

29) R.R. Wei, L. Cheng, M. Zheng, R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–Lipoic Acid Conjugates for Triggered Intracellular Anticancer Drug Release, Biomacromolecules 2012, 13, 2429-2438.

30) S.K. Li, F.H. Meng, Z.J. Wang, Y.N. Zhong, M. Zheng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Polymersomes with An Ionizable Membrane: Facile Preparation, Superior Protein Loading, And Endosomal pH-Responsive Protein Release, Eur. J. Pharm. Biopharm. 2012, 82, 103-111 (invited article)

31) Y.F. Du, W. Chen, M. Zheng, F.H. Meng, and Z.Y. Zhong*, pH-Sensitive Degradable Chimaeric Polymersomes for the Intracellular Release of Doxorubicin Hydrochloride, Biomaterials 2012, 33, 7291-7299.

32) R. Cheng, X.Y. Wang, W. Chen, F.H. Meng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Poly(ε-caprolactone)-g-Poly(2-hydroxyethyl methacrylate) Graft Copolymer Micelles as Superior Nano-Carriers for “Smart” Doxorubicin Release, J. Mater. Chem. 2012, 22, 11730-11738.

33) M. Zheng, Z.H. Zhong, L. Zhou, F.H. Meng, R. Peng, and Z.Y. Zhong*, Poly(ethylene oxide) Grafted with Short Polyethylenimine Gives DNA Polyplexes with Superior Colloidal Stability, Low Cytotoxicity and Potent In Vitro Gene Transfection Under Serum Conditions, Biomacromolecules 2012, 13, 881–888.

34) W. Wang, H.L. Sun, F.H. Meng, S.B. Ma, H.Y. Liu, and Z.Y. Zhong*, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding, Soft Matter 2012, 8, 3949-3956.

35) C.H. Zhu, M. Zheng, F.H. Meng, F.M. Mickler, N. Ruthardt, X.L. Zhu, and Z.Y. Zhong*, Reversibly Shielded DNA Polyplexes Based on Bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA Triblock Copolymers Mediate Markedly Enhanced Nonviral Gene Transfection,Biomacromolecules 2012, 13, 769–778.

36) J.C. Zhang, L.L. Wu, F.H. Meng, Z.J. Wang, C.Deng, H.Y. Liu, and Z.Y. Zhong*, pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery, Langmuir 2012, 28, 2056–2065. (invited article)

37) M. Zheng, C.M. Yang, F.H. Meng, R. Peng, and Z.Y. Zhong*, pH-Sensitive Degradable Hydrophobe Modified 1.8 kDa Branched Polyethylenimine, as “Artificial Viruses” for Safe and Efficient Intracellular Gene Transfection, Macromol. Res. 2012, 20, 327-334 (Invited Article)

38) F.X. Zhan, W. Chen, Z.J. Wang, W.T. Lu, R. Cheng, C. Deng, F.H. Meng, H.Y. Liu and Z.Y. Zhong*, Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release, Biomacromolecules 2011, 12, 3612–3620.

39) R. Cheng, F.H. Meng, S.B. Ma, H.F. Xu, H.Y. Liu, X.B. Jing, and Z.Y. Zhong*, Reduction and Temperature Dual-Responsive Crosslinked Polymersomes for Targeted Intracellular Protein Delivery, J. Mater. Chem. 2011, 21, 19013-19020.

40) M. Zheng, Y.N. Zhong,F.H. Meng, R. Peng, and Z.Y. Zhong*, Lipoic Acid Modified Low Molecular Weight Polyethylenimine Mediates Nontoxic and Highly Potent In Vitro Gene Transfection,Mol. Pharmaceutics,2011,8, 2434-2443.

41) Z.Z. Liu, M. Zheng, F.H. Meng, and Z.Y. Zhong*, Non-Viral Gene Transfection In Vitro Using Endosomal pH-Sensitive Reversibly Hydrophobilized Polyethylenimine, Biomaterials 2011, 32, 9109-9119.

42) R. Wang, W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Unprecedented Access to Functional Biodegradable Polymers and Coatings, Macromolecules 2011, 44, 6009–6016.

43) Y.H. Cong, H. Liu, D.L. Wang, B.J. Zhao, T.Z. Yan, L.B. Li , W. Chen, Z.Y. Zhong , M.-C. Lin, H.-L. Chen, and C.L. Yang, Stretch-Induced Crystallization through Single Molecular Force Generating Mechanism, Macromolecules 2011, 44, 5878-5882.

44) J. Chen, W. Chen, C. Deng, F.H. Meng, and Z.Y. Zhong*, Controlled Surface-Initiated Ring-Opening Polymerization of L-Lactide from Risedronate-Anchored Hydroxyapatite Nanocrystals: Novel Synthesis of Biodegradable Hydroxyapatite/Poly(L-lactide) Nanocomposites, J. Polym. Sci. Part A: Polym. Chem. 2011, 49, 4379-4386.

45) R. Yang, F.H. Meng, S.B. Ma, F.S. Huang, H.Y. Liu, and Z.Y. Zhong*, Galactose-Decorated Crosslinked Biodegradable Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel, Biomacromolecules 2011, 12, 3047–3055.

46) Y.X. Yu, C. Deng, F.H. Meng, Q. Shi, J. Feijen, and Z.Y. Zhong*, Novel Injectable Biodegradable Glycol Chitosan-Based Hydrogels Crosslinked by Michael-Type Addition Reaction with Oligo(acryloyl carbonate)-b-Poly(ethylene glycol)-b-Oligo(acryloyl carbonate) Copolymers, J. Biomed. Mater. Res. Part A 2011, 99A, 316-326.

47) S.B. Luo, R. Cheng, F.H. Meng, T.G. Park, and Z.Y. Zhong*, Water Soluble Poly(histamine acrylamide) with Superior Buffer Capacity Mediates Efficient and Nontoxic In Vitro Gene Transfection, J. Polym. Sci. Part A: Polym. Chem. 2011, 49, 3366–3373.

48) F.H. Meng, and Z.Y. Zhong*,Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug and Robust Vesicles for Virus and Cell-MimickingJ. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective)

49) H.L. Sun, F.H. Meng, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, a-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway and Biomedical Applications, Biomacromolecules 2011, 12, 1937-1955.

50) J. Xiong, F.H. Meng, C. Wang, R. Cheng, Z. Liu, and Z.Y. Zhong*, Folate-Conjugated Crosslinked Biodegradable Micelles for Receptor-Mediated Delivery of Paclitaxel, J. Mater. Chem. 2011, 21, 5786-5794.

51) L. Zhou, R. Cheng, H.Q. Tao, S.B. Ma, W.W. Guo, F.H. Meng, H.Y. Liu, Z. Liu, and Z.Y. Zhong*, Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice, Biomacromolecules 2011, 12, 1460–1467.

52) Y.H. Wang, M. Zheng, F.H. Meng, J. Zhang, R. Peng, and Z.Y. Zhong*, Branched Polyethylenimine Derivatives with Reductively Cleavable Periphery for Safe and Efficient In Vitro Gene Transfer, Biomacromolecules 2011, 12, 1032-1040.

53) R. Cheng, F. Feng, F.H. Meng, C. Deng, J. Feijen, Z.Y. Zhong*, Glutathione-Responsive Nano-Vehicles as a Promising Platform for Targeted Intracellular Drug and Gene Delivery, J. Control. Release 2011, 152, 2-12.

54) Z.Y. Zhong*, and J. Feijen, The First Symposium on Innovative Polymers for Controlled Delivery, September 14-17, 2010, Suzhou, China, J. Control. Release 2011, 152, 1-1.

55) G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng,*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585.

56) R. Jin, L.S. MoreiraTeixeira, P.J. Dijkstra, Z.Y. Zhong, C.A. van Blitterswijk, M. Karperien, J. Feijen, Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering, Tissue Engineering Part A. 2010,16, 2429-2440.

57) C.H. Zhu, S.Y. Jung, G.Y. Si, R. Cheng, F.H. Meng*, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection, J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 2869–2877.

58) H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.

59) R. Namgung, J.H. Brumbach, J.H. Jeong, J.W. Yockman, S.W. Kim, C. Lin, Z.Y. Zhong, J. Feijen, J.F.J. Engbersen, and W.J. Kim*, Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA, Biotechnol. Lett. 2010, 32, 755-764.

60) C.H. Zhu, S.Y. Jung, S.B. Luo, F.H. Meng, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Co-delivery of siRNA and Paclitaxel into Cancer Cells by Biodegradable Cationic Micelles Based on PDMAEMA-PCL-PDMAEMA Triblock Copolymers, Biomaterials 2010, 31, 2408–2416.

61) W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.

62) W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207.

63) J.M. Jukes, L.J. van der Aa, C. Hiemstra, T. van Veen, P.J. Dijkstra, Z.Y. Zhong, J. Feijen, C.A. van Blitterswijk, J. de Boer, A newly developed chemically crosslinked Dex-PEG hydrogel for cartilage tissue engineering, Tissue Engineering Part A. 2010, 16: 565-573.

64) Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918.

65) Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261.

66) H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Chiral Salan Aluminum Ethyl Complexes and Their Application in Lactide Polymerization, Chem.-Eur. J. 2009, 15: 9836-9845.

67) H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng *, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin,Biomaterials2009, 30: 6358-6366.

68) W. Chen, F.H. Meng, F. Li, S.-J. Ji, Z.Y. Zhong*, pH-Responsive Biodegradable Micelles Based on Acid-Labile Polycarbonate Hydrophobe: Synthesis and Triggered Drug Release, Biomacromolecules 2009, 10: 1727-1735.

69) H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.

70) F.H. Meng, W.E.Hennink, Z.Y. Zhong*, Reduction-Sensitive Polymers and Bioconjugates for Biomedical Applications, Biomaterials 2009, 30:2180-2198.

71) R. Jin, L.S. Moreira Teixeira, P.J. Dijkstra, M. Karperien, Z.Y. Zhong, J. Feijen, Injectable Chitosan-based Hydrogels for Cartilage Tissue Engineering, Biomaterials 2009, 30:2544-2551

72) H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Polymerization of lactide using achiral bis(pyrrolidene) schiff base aluminum complexes, Macromolecules 2009, 42: 1058–1066.

73) F.H. Meng, Z.Y. Zhong*, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10: 197-209.

74) C. Lin, C.-J. Blaauboer, M. Mateos Timoneda, M.C. Lok, M. van Steenbergen, W.E. Hennink, Z.Y. Zhong, J. Feijen, and J.F.J. Engbersen, Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery, J. Control. Release, 2008, 126: 166-174.

75) C. Lin, Z.Y. Zhong, M.C. Lok, Holger K. de Wolf, W.E. Hennink, J. Feijen, J.F.J. Engbersen, Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells, J. Control. Release, 2008, 132: e9-e10.

76) R. Jin, L.S. Moreira Teixeira, P.J. Dijkstra, M. Karperien, Z. Zhong, J. Feijen, Fast in-situ formation of dextran-tyramine hydrogels for in vitro chondrocyte culturing, J. Control. Release, 2008, 132: e24-e26.

77) C. Hiemstra, W. Zhou, Z.Y. Zhong*, M. Wouters, and J Feijen*, Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization, J. Am. Chem. Soc. 2007, 129: 9918-9926.

78) M. Roerdink, T.S. van Zanten, M.A. Hempenius, Z.Y. Zhong, J. Feijen, and G.J. Vancso, Poly(ferrocenylsilane-block-lactide) Block copolymers, Macromol.Rapid Commun.2007, 28: 2125-2130.

79) C. Lin, Z.Y. Zhong*, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Random and block copolymers of bioreducible poly(amido amine)s with high-and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection, J. Control. Release, 2007, 123: 67-75.

80) C. Hiemstra, Z.Y. Zhong*, M. J. van Steenbergen, W.E. Hennink, and J. Feijen*, Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels, J. Control. Release 2007, 122: 71-78.

81) C. Hiemstra, Z.Y. Zhong*, S.R. van Tomme, M. J. van Steenbergen, J.J.L. Jacobs, W. den Otter, W.E. Hennink, and Jan Feijen*, In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels, J. Control. Release 2007, 119: 320-327.

82) C. Hiemstra, L.J. van der Aa, Z.Y. Zhong*, and J. Feijen*, Rapidly in situ forming degradable hydrogels from dextran thiols through Michael addition, Biomacromolecules2007, 8: 1548-1556.

83) F. Rusmini, Z.Y. Zhong*, and J. Feijen*, Protein immobilization strategies for protein biochips, Biomacromolecules 2007, 8: 1775-1789.

84) R. Jin, C. Hiemstra, Z.Y. Zhong*, and J. Feijen*, Enzyme-mediated fast in-situ formation of hydrogels from dextran-tyramine conjugates, Biomaterials 2007, 28: 2791-2800.

85) C. Hiemstra, L.J. van der Aa, Z.Y. Zhong*, P.J. Dijkstra, and J. Feijen*, Novel in situ forming, degradable dextran hydrogels by Michael addition chemistry: synthesis, rheology and degradation, Macromolecules 2007, 40: 1165-1173.

86) L.V. Christensen, C.W. Chang, J.W. Yockman, R. Conners, H. Jackson, D.A. Bull, Z.Y. Zhong, J. Feijen, and S.W. Kim, Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery, J. Control. Release 2007, 118: 254-261.

87) J.H. Jeong, L.V. Christensen, J.W. Yockman, Z.Y. Zhong, J.F.J. Engbersen, W.J. Kim, J. Feijen, S.W. Kim, Reducible poly(amido ethylenimine) directed to enhance RNA interference, Biomaterials 2007, 28: 1912-1917.

88) C. Lin, Z.Y. Zhong*, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Novel bioreducible poly(amido amine)s for highly efficient gene delivery, Bioconjugate Chem. 2007,18: 138-145.

89) L.B. Li, F.H. Meng, Z.Y. Zhong, D. Byelov, W.H. de Jeu, and J. Feijen, Morphology of a highly asymmetric double crystallizable poly(e-caprolactone-b-ethylene oxide) block copolymer, J. Chem. Phys., 2007, 126: Art. No. 024904.

90) M.R. ten Breteler, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Ring-opening polymerization of substituted e-caprolactones using a chiral (salen) AlOiPr-Complex, J. Polym. Sci. Part A, Polym. Chem. 2007, 45: 429-436.

91) C. Lin, Z.Y. Zhong*, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties, J. Control. Release, 2006, 116: 130-137.

92) C. Hiemstra, Z.Y. Zhong, X. Jiang, W.E. Hennink, P.J. Dijkstra, and J. Feijen, PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation, J. Control. Release,2006, 116: e17-e19.

93) C. Hiemstra, Z.Y. Zhong, S.R. van Tomme, W.E. Hennink, P.J. Dijkstra, and J. Feijen, Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers, J. Control. Release, 2006, 116: e19-e21.

94) C. Lin, T.M. Lammens, Z.Y. Zhong, H. Gu, M.C. Lok, X. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen, Disulfide-containing poly(β-amino ester)s for gene delivery, J. Control. Release, 2006, 116: e79-e81.

95) Z.Y. Zhong*, C. Lin, Y. Ma, M.A. Hempenius, M.C. Lok, M.M. Fretz, J.F.J. Engbersen, G.J. Vancso, W.E. Hennink, and J. Feijen, Water-soluble cationic poly(ferrocenylsilane): an efficient DNA condensation and transfection agent, J. Control. Release, 2006, 116: e81-e83.

96) C. Hiemstra, Z.Y. Zhong*, L.B. Li, P.J. Dijkstra, and J. Feijen*, In situ formation of biodegradable hydrogels by stereocomplexation of PEG-(PLLA)8 and PEG-(PDLA)8 star block copolymers, Biomacromolecules 2006, 7: 2790-2795.

97) L.V. Christensen, C.W. Chang, W.J. Kim, S.W. Kim*, Z.Y. Zhong*, C. Lin, J.F.J. Engbersen*, and J. Feijen, Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery, Bioconjugate Chem., 2006, 17: 1233-1240.

98) M. Leemhuis, C.F. van Nostrum, J.A.W. Kruijtzer, Z.Y. Zhong, M.R. ten Breteler, P.J. Dijkstra, J. Feijen, and W.E. Hennink, Functionalized poly(-hydroxy acid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups, Macromolecules, 2006, 39: 3500-3508.

99) G. Engbers, A. Poot, D. Grijpma, Z.Y. Zhong, and P. Dijkstra, Professor Jan Feijen-30 years research in biomedical technology, J. Control. Release 2005, 109: 2-4.

100) Z.Y. Zhong, J. Feijen, M.C. Lok, W.E. Hennink, L. Christensen, J.W. Yockman, Y.-H. Kim, and S.W. Kim, Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization and in vitro gene transfer properties, Biomacromolecules, 2005, 6: 3440-3448.

101) Z.Y. Zhong, Y. Song, J.F.J. Engbersen, M.C. Lok, W.E. Hennink, and J. Feijen, A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s. J. Control. Release 2005, 109: 317-329.

102) C. Hiemstra, Z.Y. Zhong, P. Dijkstra, and J. Feijen, Stereocomplex mediated gelation of PEG-(PLA)(2) and PEG-(PLA)(8) block copolymers. Macromol. Symp., 2005, 224: 119-131.

103) Z. Zhong, M.C. Lok, P.J. Dijkstra, W.E. Hennink, and J. Feijen, Structurally well-defined copolymers of poly(ethylene glycol) and low molecular weight linear polyethylenimine as vectors for gene delivery. J. Control. Release, 2005, 101(1-3): 406-408.

104) C. Hiemstra, Z. Zhong, P.J. Dijkstra, and J. Feijen, PEG-PLA hydrogels by stereocomplexation for tissue engineering of cartilage. J. Control. Release, 2005, 101(1-3): 332-334.

105) G. Becker, M. Niemeyer, O. Mundt, W. Schwarz, M. Westerhausen, M.W. Ossberger, P. Mayer, H. Noth, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Crystal structures and spectroscopic properties of 2 lambda(3)-phospha-1,3-dionates and 1,3-dionates of calcium - Comparative studies on the 1,3-diphenyl and 1,3-Di(tert-butyl) derivatives. Z. Anorg. Allg. Chem., 2004, 630(15): 2605-2621.

106) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Controlled synthesis of biodegradable lactide polymers and copolymers using novel in situ generated or single-site stereoselective polymerization initiators. J. Biomater. Sci.-Polym. Ed., 2004, 15(7): 929-946.

107) L.B. Li, Z.Y. Zhong, W.H. de Jeu, P.J. Dijkstra, and J. Feijen, Crystal structure and morphology of poly(L-lactide-b-D-lactide) diblock copolymers. Macromolecules, 2004, 37(23): 8641-8646.

108) M. Westerhausen, S. Schneiderbauer, A.N. Kneifel, Y. Soltl, P. Mayer, H. Noth, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Organocalcium compounds with catalytic activity for the ring-opening polymerization of lactones. Eur. J. Inorg. Chem., 2003, (18): 3432-3439.

109) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Determination of the Stereoselectivity Factor for an Asymmetric Enantiomer-Differentiating Polymerization: a Revisit. Macromolecules, 2003, 36(21): 8198-8200.

110) Z.Y. Zhong, S. Schneiderbauer, P.J. Dijkstra, W. M., and J. Feijen, Single-site calcium initiators for the controlled ring-opening polymerization of lactides and lactones. Polym. Bull., 2003, 51: 175-182.

111) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, controlled and stereoselective polymerization of lactide: kinetics, selectivity, and microstructures. J. Am. Chem. Soc., 2003, 125(37): 11291-11298.

112) A.P. Pego, Z.Y. Zhong, P.J. Dijkstra, D.W. Grijpma, and J. Feijen, Influence of catalyst and polymerization conditions on the properties of 1,3-trimethylene carbonate and epsilon- caprolactone copolymers. Macromol. Chem. Phys., 2003, 204(5-6): 747-754.

113) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, [(salen)Al]-mediated, controlled and stereoselective ring-opening polymerization of lactide in solution and without solvent: Synthesis of highly isotactic polylactide stereocopolymers from racemic D,L-lactide. Angew. Chem. Int. Edit., 2002, 41(23): 4510-4513.

114) Z.Y. Zhong, P.J. Dijkstra, J. Feijen, Y.M. Kwon, Y.H. Bae, and S.W. Kim, Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers. Macromol. Chem. Phys., 2002, 203(12): 1797-1803.

115) Z.Y. Zhong, S. Schneiderbauer, P.J. Dijkstra, M. Westerhausen, and J. Feijen, Fast and living ring-opening polymerization of L-lactide initiated with in-situ-generated calcium alkoxides. J. Polym. Environ., 2001, 9(1): 31-38.

116) Z.Y. Zhong, M.J.K. Ankone, P.J. Dijkstra, C. Birg, M. Westerhausen, and J. Feijen, Calcium methoxide initiated ring-opening polymerization of epsilon-caprolactone and L-lactide. Polym. Bull., 2001, 46(1): 51-57.

117) Z.Y. Zhong, P.J. Dijkstra, C. Birg, M. Westerhausen, and J. Feijen, A novel and versatile calcium-based initiator system for the ring-opening polymerization of cyclic esters. Macromolecules, 2001, 34(12): 3863-3868.

118) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Controlled ring-opening polymerization of omega- pentadecalactone with yttrium isopropoxide as an initiator. Macromol. Chem. Phys., 2000, 201(12): 1329-1333.

119) Z.Y. Zhong, D.H. Yu, F.H. Meng, Z.H. Gan, and X.B. Jing, Controlled synthesis of L-lactide-b-epsilon-caprolactone block copolymers using a rare earth complex as catalyst. Polym. J., 1999, 31(8): 633-636.

120) Z.H. Gan, D.H. Yu, Z.Y. Zhong, Q.Z. Liang, and X.B. Jing, Enzymatic degradation of poly(epsilon-caprolactone)/poly(DL- lactide) blends in phosphate buffer solution. Polymer, 1999, 40(10): 2859-2862.

121) J. Zhang, Z.H. Gan, Z.Y. Zhong, and X.B. Jing, A novel rare earth coordination catalyst for polymerization of biodegradable aliphatic lactones and lactides. Polym. Int., 1998, 45(1): 60-66.