Multimodal Cancer Imaging and Therapy
Huabing Chen
B.S. & Ph. D. Huazhong University of Science & Technology, China 2001 & 2008
Postdoc. University of Texas Southwestern Medical Center at Dallas & University of Tokyo, 2008-2012

Research interests
The research interests in Dr. Chen’s group are focusing on nanomedicine and molecular imaging for early cancer detection and cancer-targeted therapy. In particular, the nanoparticles are being developed to achieve multimodal imaging (MRI, fluorescence, CT, photoacoustics, etc) with high spatial resolution and ultra-sensitivity, and multimodal cancer therapy (e.g. chemotherapy, photothermal and photodynamic therapy) with synergistic effects.
Representative publications
1.  Guo M.; Mao H. J.; Li Y. L.;  Zhu A. J.; He H.; Yang H.; Wang Y. Y.; Tian X.; Ge C. C.; Peng Q. L.; Wang X. Y.; Yang X. L.; Chen X. Y.; Liu G.;* Chen H. B.* Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials, 2014, 35(16): 4656-4666
2. Wan Z. H.; Mao H. J.; Guo M.; Li Y. L.; Zhu A. J.; Yang H.; He H.; Shen J. K.; Zhou L. J.; Jiang Z.; Ge C. C.; Chen X. Y.; Yang X. L.; Liu G.; Chen H. B.* Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics, 2014, 4(4): 399-411
3. Chen H. B.; Xiao L.; Anraku Y.; Mi P.; Liu X. Y.; Cabral H.; Inoue A.; Nomoto T.; Kishimura A;* Nishiyama N.;* Kataoka K.* Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J. Am. Chem. Soc., 2014, 136(1): 157-163 
4. Yang H.; Mao H. J.; Wan Z. H.; Zhu A. J.; Guo M.; Li Y. L.; Li X. M.; Wan J. L.; Yang X. L.; Shuai X. T.;Chen H. B.* Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34(36): 9124-9133
5. Huang G.;# Chen H. B.;# Dong Y.; # Luo X. Q.; Yu H. J.; Moore Z; Bey E. A.; Boothman D. A.;* Gao J. M.* Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics, 2013, 3(2): 116-126
6. Chen H. B.; Zhu H. D.; Hu J. D.; Zhao Y. B.; Wang Q.; Wan J. L.; Yang Y. J.; Xu H. B.; Yang X. L.* Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine. ACS Nano, 2011, 5(4): 2671-2680
7. Chen H. B.; Khemtong C.; Yang X. L.; Chang X. L.; Gao J. M.* Nanonization strategies for poorly water-soluble drugs. Drug Discov. Today, 2011, 16(7-8): 354-360
8. Chen H. B.; Xiao L.; Du D. R.; Mou D. S.; Xu H. B.; Yang X. L.* A facile construction strategy of highly stable nanoparticles for drug delivery using a hydrogel-thickened microemulsion system as a template, Nanotechnology, 2010, 21(1): 015101
9. Chen H. B.; Zhu H. D.; Zheng J. N.; Mou D. S.; Wan J. L.; Zhang J. Y.; Shi T. L.; Zhao Y. J.; Xu H. B.; Yang X. L.* The iontophoresis-driven penetration of lecithin-based nanovesicles through microneedle-induced skin microchannels for transdermal delivery of insulin. J. Control. Release, 2009, 139(1): 63-72.
10. Chen H. B.; Wan J. L.; Wan Y. R.; Mou D. S.; Liu H. B.; Xu H. B.; Yang X. L.* A facile nanoaggregation strategy for oral delivery of hydrophobic drug by utilizing acid-base neutralization reaction, Nanotechnology, 2008, 19(37), 375104.
11. Mou D. S.; Chen H. B.;* Du D. R.; Mao C. W.; Wan J. L.; Xu H. B.; Yang X. L.* Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int. J. Pharm., 2008, 353(1-2): 270-276.
12. Chen H. B.; Mou D. S.; Du D. R.; Chang X. L.; Zhu D. D.; Liu J.; Xu H. B.; Yang X.  L.* Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. Int. J. Pharm., 2007, 341(1-2): 78-84.
13. Chen H. B.; Chang X. L.; Du D. R.; Liu W.; Liu J.; Weng T.; Yang Y. J.; Xu H. B.; Yang X. L.* Podophyllotoxin-loaded Solid lipid nanoparticles for epidermal targeting. J. Control. Release, 2006, 110(2): 296-306.
14. Chen H. B.; Chang X. L.; Du D. R.; Li J.; Xu H. B.; Yang X. L.* Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int. J. Pharm., 2006, 315(1-2): 52-58.
15. Chen H. B.; Chang X. L.; Weng T.; Zhao X. Z.; Gao Z. H.; Yang Y. J.; Xu H. B.; Yang X. L.* A study of microemulsion systems for transdermal delivery of triptolide. J. Control. Release, 2004, 98(3): 427-436.
Book chapter
Chen H. B.; Ge Z. S.; Kataoka K. Polymeric micelles for cancer-targeted drug delivery.  Bioinspired and Biomimetic Systems for Drug and Gene Delivery, Wiley, 2014, 85-107
Research grants
1. Polymeric micelles for bidirectionally synergistic effects of photothermal and molecularly targeted cancer therapies, National Natural Science Foundation of China (2015-2018)
2. Activable near-infrared fluorescent nanoprobe for early detection of liver metastasis, National Natural Science Foundation of China, 81202472 (2013-2015)
Selected honors/awards
1. National Natural Science Foundation of China for Excellent Young Scholars (2015-2017)
2. Double Innovative Program of Jiangsu Province (2014-2016)

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