Controlled Release and Enhanced Oral Bioavailability
Qingri Cao
Associate Professor
B.S. Yanbian University, China, 1996
Ph.D. Kangwon National University,South Korea, 2004

Research interests
1. Tumor-targeted microenvironment-responsive carbon nanotubes for delivery of anticancer drugs and siRNA
2. Oral absorption mechanism of solid lipid nanoparticles
3. Development of novel sustained/controlled release dosage forms, orodispersible films and solid disperstions
Representative publications
1. Xu LL, Xu WJ, Shi LL, Cao QR*, Cao Y, Zhu XY, Cui JH. Formulation and in vitro characterization of novel sildenafil citrate-loaded polyvinyl alcohol-polyethylene glycol graft copolymer-based orally dissolving films. Int J Pharm, 2014, 473, 398-406.
2. Shi LL, Xu WJ, Cao QR*, Yang MS, Cui JH*. Preparation, characterization and in vitro evaluation of polyvinyl alcohol/sodium alginate based orodispersible film containing sildenafil citrate. Pharmazie, 2014, 69, 327-334.
3. Cao QR*, Piao YN, Choi JS, Liu Y, Yang MS, Cui JH*. Design,in vitro release characterization and pharmacokinetics of novel controlled release pellets containing levodropropizine. Pharm Dev Tech, 2014, 19, 296-303.
4. Cao QR*, Choi JS, Liu Y, Xu WJ, Yang MS, Lee BJ, Cui JH*. A formulation approach for development of HPMC-based sustained release tablets for tolterodine tartrate with a low release variation. Drug Dev Ind Pharm, 2013, 39,1720-1730.
5. Cao QR, Liu Y, Xu WJ, Lee BJ, Yang MS, Cui JH*. Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique. Int J Pharm, 2012, 434, 325–333.
6. Cao QR*, Wu HN, Zhu L, Wu D, Zhu YF, Zhu ZX, Cui JH. Preparation and evaluation of zanamivir- loaded solid lipid nanoparticles. J Control Release, 2011, 152(supplement 1), e2-e4.
7. Cao QR, Cui JH, Park JB, Han HK, Lee JH, Oh KT, Park IC, Lee BJ. Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats, Int J Pharm, 2010, 396, 39-44.
8. Cao QR, Lee ES, Choi YJ, Cho CS, Lee BJ. Rumen bypass and biodistribution of l-carnitine from dual-layered coated pellets in cows, in vitro and in vivo, Int J Pharm, 2008, 359, 87-93.
9. Cao QR, Ren S, Park MJ, Choi YJ, Lee BJ. Determination of highly soluble L-carnitine in biological samples by reverse phase high performance liquid chromatography with fluorescent derivatization, Arch Pharm Res, 2007, 30, 1041-1046.
10. Cao QR, Kim TW, Lee BJ. Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with and highly drug loadings, Int J Pharm, 2007, 339, 19-24.
11. Cao QR, Choi YW, Cui JH, Lee BJ. Formulation, release characteristics and bioavailability of novel monolithic hydroxypropylmethylcellulose matrix tablets containing acetaminophen. J Control Release, 2005, 108, 351-361.
12. Cao QR, Kim TW, Choi JS, Lee BJ. Circadian variations in the pharmacokinetics, tissue distribution and urinary excretion of nifedipine after a single oral administration to rats, Biopharm Drug Dispos, 2005, 26, 427-437.
13. Cao QR, Choi YW, Cui JH, Lee BJ. Effect of solvents on physical properties and release characteristics of monolithic hydroxypropylmethylcellulose matrix granules and tablets. Arch Pharm Res, 2005, 28,493-501.
14. Cao QR, Choi HG, Kim DC, Lee BJ. Release behavior and photo-image of nifedipine tablet coated with high viscosity grade hydroxypropyl methylcellulose: Effect of coating conditions. Int J Pharm, 2004, 274, 107-117.
1. Cao QR,Shi LL,Cui JH. Sildenafil-loaded mouth dissolving films and preparation process thereof, Application No.: CN201410226345.9, Application date: 2014-05-24
2. Cao QR, Shi LL, Xu WJ, Cui JH. Mouth dissolving films and preparation process thereof, Application No.: CN 201210363306.4, Application date: 2012-9-29 (Granted)
3. Cao QR, Liu Y, Cui JH. Sustained release tablets of quetiapine fumarate, Application No.: CN 201210123709.1, Application date: 2012-04-25 (Granted)
4. Cao QR, Xu WJ, Cui JH. Valsartan solid dispersions and preparation process thereof, Application No.: CN 201110314105.0, Application date: 2011-10-17
5. Cao QR, Liu Y, Cui JH. Sustained release tablets of quetiapine fumarate and preparation process thereof, Application No.: CN 201110314104.6, Application date: 2011-10-17 (Granted)
6. Cao QR, Liu Y, Cui JH. Telmisartan solid dispersions and preparation process thereof, CN 201110110988.3, Application date: 2011-04-29
7. Cao QR, Cui JH. Bioadhesive polymer-coated pellets and preparation process thereof, Application No.: CN 201010590790.5, Application date: 2010-12-16
8. Cao QR, Cui JH. Zanamivir-loaded solid lipid nanoparticles for oral administration and preparation process thereof. Application No.: CN 201010590798.1, Application date: 2010-12-16 (Granted)

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