Design of Functional materials, Evaluation of Targeting Drug Delivery System
Liang Cheng
Associate Professor
B.S. Huazhong University of Science and Technology, Wuhan, China 2001 & 2005
Ph.D. Shanghai Jiaotong University, Shanghai, China 2005 & 2010

The research of Dr. Cheng is mainly focusing on the design and synthesis of functional materials with excellent biodegradable and biocompatible properties; construction of drug-loaded nano-sized carriers; to study intracellular drug release mechanism of nanomedicine; to evaluate in vivo antitumor activity.  
SELECTED Peer-reviewed publication
1.Wen Hu, Liang Cheng, Lifang Cheng, Meng Zheng, Qifu Lei, Ziyang Hu, Ming Xu, Lipeng Qiu, Dawei Chen*, Redox and pH-responsive Poly (amidoamine) dendrimer-poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release. Colloid Surface B 2014, Accept.
2.Yaqin Zhu, Liang Cheng, Lifang Cheng, Fazhen Huang, Qing Hu, Ling Li, Chenmin Tian, Lin Wei, Dawei Chen*, Folate and TAT Peptide Co-Modified Liposomes Exhibit Receptor-Dependent Highly Efficient Intracellular Transport of Payload In Vitro and In Vivo. Pharm. Res. 2014, Available Online.
3.Liang Cheng, Fazhen Huang, Lifang Cheng, Yaqin Zhu, Qing Hu, Ling Li, Lin Wei, Dawei Chen*, GE11-modified liposomes for non-small cell lung cancer targeting: preparation, ex vitro and in vivo evaluation. Int. J. Nanomed. 2014, 9, 921-935.
4.Rongran Wei, Liang Cheng, Meng Zheng, Ru Cheng, Fenghua Meng, Chao Deng, Zhiyuan Zhong*, Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)−Lipoic Acid Conjugates for Triggered Intracellular Anticancer Drug Release. Biomacromolecules 2012, 13, 2429-2438.
5.Lei Lei, Liang Cheng, Jingwen Hou, Shengrong Guo, Chuangang Zhu, Yaojun Shi, Yan Jiang, Jiaojiao Lin, Prevention of Schistosoma japonicum infection in mice with long-acting praziquantel implants. Exp. Parasitol. 2012, 131, 442-447.
6.Cheng L, Lei L, Guo SR, Zhu CG, Rong HJ, Guo DW, Zhang L, Jiang Y, Lin JJ. Schistosoma japonicum: Treatment of different developmental stages in mice with long-acting praziquantel implants. Exp. Parasitol. 2011, 129, 254-259.
7.Hou JW, Li CY, Cheng L, Guo SR, Zhang YQ, Tang TT. Study on hydrophilic 5-fluorouracil release from hydrophobic poly(epsilon-caprolactone) cylindrical implants. Drug Dev. Ind. Pharm. 2011, 37, 1068-1075.
8.Cheng L, Lei L, Guo SR. In vitro and in vivo evaluation of praziquantel loaded implants based on PEG/PCL blends. Int. J. Pharm. 2010, 387, 129-138.
9.Li CY, Cheng L, Guo SR, Wu WP. Effects of implant diameter, drug loading and end-capping on praziquantel release from PCL implants. Int. J. Pharm. 2010, 386, 23-29.
10.Cheng L, Guo SR, Wu WP. Characterization and in vitro release of praziquantel from poly(ε-caprolactone) implants. Int. J. Pharm. 2009, 377, 112-119.
11.Wang SB, Guo SR, Cheng L. Disodium norcantharidate loaded poly(ε-caprolactone) microspheres: I. Preparation and evaluation. Int. J. Pharm. 2008, 350, 130-137.
12.Yang H, Cheng L, Guo SR. Study on acicular poly(ε-caprolactone) implants containing 5-fluorouracil. Chinese Pharm. J. 2009, 44, 602-606.
1. National Natural Science Foundation of China (Grant No. 81202473, 2013-2015).
2. Natural Science Foundation of Jiangsu Province (Grant No. BK2012182, 2013-2015).

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