Design and Evaluation of Functional Drug Delivery System
Lifang Cheng
Associate Professor
B.S. Yangzhou University, Jiangsu, China 2000-2004
Ph.D. Jiangnan University, Jiangsu, China 2004-2010
Visiting Scholar University of North Carolina at Chapel Hill, USA, 2014-2015

1. Design and construction of novel functional drug and gene delivery systems;
2. In vitro and in vivo anti-tumor activity evaluation of novel DDS;
3 Study of intracellular drug transport mechanism.   

SELECTED Peer-reviewed publication 
1. Hu, Qing Chen, Xiuyun Yan, Bomei Ding, Dawei Chen*, Lifang Cheng*. Chondrocyte affinity peptide modified PAMAM conjugate as a nanoplatform fortargeting and retention in cartilage, Nanomedicine, 2018, doi: 10.2217/nnm-2017-0335.

2. Qing Hu, Bomei Ding, Xiuyun Yan, Jia Duan, Shu Yang, Lifang Cheng*, Dawei Chen*.  Polyethylene glycol modified PAMAM dendrimer delivery of kartogenin to induce chondrogenic differentiation of mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2017,13(7),2189-2198.

3. Lifang Cheng, Yuhua Huang, Leaf Huang*.Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Proinflammatory Microenvironment in the Lymph Node. Molecular Therapy, 2017,25,1665-1675.

3. Wen Hu, Lipeng Qiu, Liang Cheng, Qing Hu, Yang Liu, Ziyang Hu, Dawei Chen*,  Lifang Cheng*. Redox and pH dual responsive poly (amidoamine) dendrimer-poly (ethylene glycol) conjugates for intracellular delivery of doxorubicin. Acta Biomaterialia, 2016, 36: 241-253.

4. Lifang Cheng, Qing Hu, Liang Cheng, Yaqin Zhu, Lu Zhang, Dawei Chen*.  Construction and Evaluation of PAMAM-DOX Conjugates with Superior Tumor Recognition and Intracellular Acid-Triggered Drug Release Properties. Colloids and surfaces BBiointerfaces, 2015, 136: 37-45.

5. Wen Hu, Liang Cheng, Lifang Cheng, Meng Zheng,  Qifu Lei, Ziyang Hu, Ming Xu, Lipeng Qiu, Dawei Chen*. Redox and pH-responsive poly (amidoamine) dendrimer–poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release. Colloids and surfaces BBiointerfaces, 2014, 123:254-263.

6. Yaqin ZhuLiang ChengLiang Cheng Fazhen HuangQing HuLing LiChenmin TianLin WeiDawei Chen*. Folate and TAT peptide co-modified liposomes exhibit receptor-dependent highly efficient intracellular transport of payload in vitro and in vivo. Pharmaceutical Research201431(1)3289-3303.

7. Lifang Cheng, Wanmeng Mu, Bo Jiang*. Thermostable L-arabinose isomerase from Bacillus stearothermophilus IAM 11001 for D-tagatose production: gene cloning, purification and characterization. J Sci food Agri, 2010, 90:1327–1333.

8. Lifang Cheng, Wanmeng Mu, Tao Zhang, Bo Jiang*. An L-arabinose isomerase from Acidothermus cellulolytics ATCC 43068: cloning, expression, purification and characterization. Appl Microbiol Biotechnol, 2010, 86(4):1089–1097.

9. Lifang Cheng, Wanmeng Mu, Bo Jiang*. Efficient biotransformation of D-galactose to D-tagatose by Acidothermus cellulolytics ATCC 43068. J Food Biochem, 2011, 35: 1298-1310.

10. Lifang Cheng, Wanmeng Mu, Tao Zhang, Bo Jiang*. Cloning, expression and partial characterization of thermostable L-arabinose isomerase from Bacillus stearothermophilus IAM 11001 for D-tagatose preparation. J Biotechnol, 2008, 136S: S741–S742.

1.      National Natural Science Foundation of China (Grant No. 81302719).

2.      Jiangsu Natural Science Foundation of China. (Grant No. BK20151224)

3.      Suzhou science and technology project of China. (Grant No. SYS201713)

4.      Natural Science Foundation of Soochow University, China. (Grant No. Q313203111)


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