Pharmaceutical Analysis
 
Glycoscience
Zhenqing Zhang
Professor
B.S. Ocean University of China, 2000
Ph.D. Ocean University of China, 2006
Post doc. Rensselaer Polytechnic Institute, NY, 2009
z_zhang@suda.edu.cn
 

Research interests:
1. Glycosaminoglycan sequencing
2. Heparin and Heparinoids develoment and quality control
3. Glycomics
4. Glycans and Glycoconjugates structure/sequence and anti-tumor cvtivitu relationship
Representative publications:
1. Z.Zhang*,N.Khan,C.M.Szabo,Complete Monosaccharide Analysis by High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection Anal.Chem.2012,84,4104-4110.
2. M.Guerrini,Z.Zhang,Z.Shriver,A.Naggi,S,Masuko,R.Langer,B.Casu,R.J.Linhardt,G,Torri,R.Sasisekharan*,Orthogonal analytical approaches to detect potential contaminants in heparin,PNAS,2009,106,16956-16961.Co-first authors.
3. Z.Zhang,J.Xie,H.Liu,J.Liu,R.J.Linhardt*.Quantitification of Heparan Sulfate Disaccharides Using Ion-pairing,Reverse-Phase,Micro-flow,High Performance LIquid Chromatography with Electrospray Ionization Trap Mass Spectrometry.Anal.Chem.,2009,81,4349-4355.
4. Z.Zhang,B.Li.J.Suwan,F.Zhang,R.J.Linhardt*.Analysis of pharmaceutical heparins and potential contaminants using H-NMT and PAGE,J.Pharma.Sci.,2009,98(11):4017-4026.
5.  Z.Zhang,Y.Park,M.M.Kemp,D.Shaya,M.Cygler,Y.S.Kim,R.J.Linhardt*.Chondroitin lyase's action pattern study using LC-MS,Anal.Biochem.,2009,385(1):57-64.
6.H.Liu,Z.Zhang,R.J.Linhardt*.Lessons learned from the contamination of heparin,Natural Product Peports(NPR),highlight paper,2009,26(3):313-321.
7. Z.Zhang,S.A.McCallum,J.Xie,L.Nieto,F.Corzana,J.Jimenez-Barbero,M.Chen,J.Liu,R.J.Linhardt*.Solution Structures of Chenoenzymatically Synthesized Heparin and Its Precursors,JACS,2008,130(39):12998-3007.
8. Z.Zhang,M.Weiwer,B,Li,M.M.Kemp,T.H.Daman,R.J.Linhardt*.Oversulfated Chondroitin Sulfate:Impact of a Heparin Impuritu,Associated with Advberse Clinical Events,on Low-Molecular-Weight Heparin Preraration..J/JC.,2008,51(18):5498-501.
9. Z.Zhang,J.Xie,J.Liu,R.J.Linhardt*.Tandem MS can distinguish hyaluronic acid from N-acetylheparosan,Journal of the American Society of Mass Spectrometry,2008,19(1):82-90.
10. Z.Zhang,J.Xie,F.Zhang,R.J.Linhardt*.Thin-layer chromatography for the analysis of glycosaminoglycan oligosaccharides.Ana.Biochem.,2007,371(1):118-120.

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