Pharmaceutical Analysis
Drug Transporters, Pharmacokinetics
Chunshan Gui
Associate Professor
Ph.D. Shanghai Institute of Materia Medica, CAS, 2005

Research interests:
1. Structure-function studies of drug transporters
2. Effects of drug transporters on pharmacokinetics
Representative publications:
1. Gui C,Obaidat A,Chaguturu R,Hagenbuch B.Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.Curr.Chem.Genomics 2010,4:1-8.
2. Gui C,Hagenbuch B.Cloning/characterization of the canine organic anion transporting polypeptide 1b4(Oatp1b4)and classification of the canine OATP/SLCO members.Comp.Biochem.Physiol.2010,151:393-399.
3. Gui C,Hagenbuch B.Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1.Protein Sci.2009,18:2298-2306.
4. Gui C,Wahlgren B,Lushington GH,Hagenbuch B.Identification,Ki determination and CoMFA analysis of nuclear receptor ligands an competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport.Pharmacol.Res.2009,60:50-56.
5. Gui C,Hagenbuch B.Amino acid residues in transmenbrane domain 10 of organic anion turansporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport.Biochemistry 2008,47:9090-9097.
6. Gui C,Miao Y,Thompson L,Wahlgren B,Mock M,Stieger B,Hagenbuch B.Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATO1B3.Eur.J.Pharmacol.2008.584:57-65.

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