Pharmaceutical Analysis
Mechanisms of Drug Metabolism & Transport
Hongjian Zhang
B.S. Beijing Normal University, 1983
M.S. University of California-Davis, 1991
Ph.D. University of California-Davis, 1994

Research interests:
1. Role of drug metabolizing enzymes(DMEs)and transporters in drug disposition
2. Mechanisms of enzyme-and/or transporter-mediated drug-drug interactions
3. DME/Transporter polymorphisms,synthetic biology and personalized medicines
Representative publications:
1. LC-MS/MS method for the simultaneous quantitation of three active components derived from a novel prodrug against schistosome infection.He G,et al.J Pharm Biomed Anal.2013 Sep;83:186-93.
2. Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949,a clinical p38α inhibitor.Liu al.Bioorg Med Chem Lett.2013.23(10):3028-33.
3. Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.Fancher RM,et al.J Pharm Sci.2011Jul;100(7):2979-88.
4. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514,a potent inhibitor of EGFR and VEGFR2.Marathe P,et al.J Pharm Sci.2010 Aug;99(8):3579-93.
5. In vitro evaluation of reversible and irreversible cytochrome P450 inhibition:current status on methodologies and their utility for predicting drug-drug interactions.Fowler S,Zhang H.AAPS J.2008 Jun;10(2):410-24.
6. Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomlogus monkeys.Zhang H,et al.Drug Metab Dispos.2007 May;35(5):795-805.
7. Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol:a new look at an old drug.Zhang H,et al.Clin Pharmacokinet.2007;46(2):133-57.

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