Pharmaceutical Analysis
Toxicology and Pharmacokinetics
Jianqing Ruan
Associate Professor
Ph.D. of School of Biomedical Sciences, The Chinese University of Hong Kong

Research Interests
1.Mechanism of drug induced liver injury and drug safety evaluation
2.Absorption, distribution, metabolism and excretion of drug candidates
3.Herb-drug interaction
Representative Publications
1.Ruan J, Yang M, Fu PP, Ye Y, and Lin, G. Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis. Chem Res Toxicol. 2014 Jun 16;27(6):1030-9.
2.Ruan J, Liao C, Ye Y, and Lin G. Lack of metabolic activation and predominant formation of an excretory metabolite, the distinctive feature of non-toxic platynecine type pyrrolizidine alkaloids. Chem Res Toxicol. 2014 Jan 21;27(1):7-16.
3.Ruan J, Li N, Xia Q, Fu PP, Peng S, Ye Y and Lin G. Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis. J Mass Spectrom. 2012 Mar;47(3):331-7.
4.Ruan J, Leong WI, Yan R and Wang YT. Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng. J Agric Food Chem. 2010 May 12;58(9):5770-6.
5.Ruan J, Yan R. Regioselective Glucuronidation of the Isoflavone Calycosin by Human Liver Microsomes and Recombinant Human UDP-glucuronosyltransferases. Chem Biol Interact. 2014 Jul 18;220C:231-240.
6.Mei M, Ruan J, Wu WJ, Zhou RN, Lei JP, Zhao HY, Yan R and Wang YT. In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use. J Agric Food Chem. 2012 Mar 7;60(9):2299-308.
7.Zhou R, Song Y, Ruan J, Wang Y and Yan R. Pharmacokinetic evidence on contribution of intestinal bacterial conversion to beneficial effects of astragaloside IV, a marker compound of Astragali Radix, in traditional oral use of the herb. Drug Metab Pharmacokinet. 2012;27(6):586-97.
8.Hu N, Mei M, Ruan J, Wu W, Wang Y and Yan R. Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs. Drug Metab Pharmacokinet. 2014 Jun 25;29(3):229-36.
9.Li N, Xia Q, Ruan J, Fu PP and Lin G. Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Curr Drug Metab. 2011 Nov;12(9):823-34.
10.Shen H, Leung WI, Ruan J, Li SL, Lei JP, Wang YT, Yan R. Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. Chin Med. 2013 Nov 23;8(1):22.

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