Microbial and Biochemical Pharmacy
Design and Selection of Therapeutic Peptides and Peptidic Tools
Xiaoyan Qiu
Associate Professor
B.S. Peking University, 1999
M.S. Rensselaer Polytechnic Institute, 2001
Ph.D. Yale University, 2007

Research interests:
Design and selection of peptide and peptidomimetic ligands.Regulation of receptor signal transduction.
Recent Publications:
1. Computational design of a protein crystal. Lanci C. J; et al. PNAS. 2012, 109(19): 7304-7309.
2. Tidal surge in the M2 proton channel sensed by 2D IR spectroscopy, Ghosh A.; et al. PNAS. 2011, 108(15): 6115-6120.
3. Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Wang J.; et al. Current OPinion in Structural Biology. 2011; 21(1): 68-80.(Review).
4. Using two fluorescent probes to dissect the binding,insertion,and dimerization kinetics of a model membrane peptide. Tang K.; et al. J. Am. Chem. Soc. 2009, 131(11): 3816-3817.
5. Tetrameric beta(3)-peptide bundles. Goodman J. L.; et al. Chem. Biochem. 2008, 1576-1578.
6. Biophysical and structural characterization of a rohust octameric beta-peptide bundle. Goodman J. L.; et al. J. Am. Chem. Soc. 2007, 129(47): 14746-14751.
7. Biophysical characterization of a beta-peptide bundle:comparison to natural proteins. Petersson E. J.; et al. J.Am. Chem. Soc.2007, 129(17): 5344-5345.
8. High resolution structure of a beta-peptide bundle, .Daniels D. S.; et al. J. Am. Chem. Soc. 2007, 129(6): 1532-1533.
9. Toward beta-amino acid proteins:a cooperatively folded beta-peptide quaternary structure. Qiu J. X.; et al. J .Am. Chem. Soc. 2006, 128: 11338-11339.
10. Helix macrodipole control of beta-peptide 14-Helix stabilitu in water. Hart S. A.; et al. J.Am. Chem. Soc. 2003,125(14): 4022-4023.

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