Microbial and Biochemical Pharmacy
 
Molecular Mechanism of Tumorigenesis
Xinchen Teng
Associate Professor
B.S. Fudan University, 2001
M.S. Fudan University, 2004
Ph.D. Johns Hopkins University, USA 2010
xcteng@suda.edu.cn
 

Research interests:
1. Development of high-throughput assays
2. Nutrient sensing signaling pathways involved in tumorigenesis
Representative publications:
1. Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM, Genome-wide consequences of deleting any single gene, Molecular Cell, 2013, 52(4), 485-494.
2. Teng X and Hardwick JM, Chapter 30-The extrinsic cell death pathway, Molecular Oncology, Cambridge University Press, 2013, 353-366.
3. Teng X and Hardwick JM, Quantification of genetically controlled cell death in budding yeast, Methods in Molecular Biology, 2013, 1004, 161-70.
4. Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM, Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential, J Cell Biol. 2011, 195(2), 263-76.
5. Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM, Gene-dependent cell death in yeast, Cell Death & Disease, 2011, 2 (e188), 1-9.
6. Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM and White K, Mitochondrial involvement in cell death of non-mammalian eukaryotes, Biochimica et Biophysica Acta, 2010, 1813(4), 597-607.
7. Teng X and Hardwick JM, The apoptosome at high resolution, Cell, 2010, 141(3), 404-406
8. Teng X and Hardwick JM, Reliable method for detection of programmed cell death in yeast, Methods in Molecular Biology, 2009, 552, 335-342 .
9. Cheng W-C, Teng X, Park HK, Tucker CM, Dunham MJ and Hardwick JM, Fis1-deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death and Differentiation, 2008, 15(12), 1838-1846.

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