Microbial and Biochemical Pharmacy
Natural Bioactive Peptides/Proteins
Yipeng Wang
Associate Professor
B.S. Liaocheng University, 2005
Ph.D. Kunming Institute of Zoology, Chinese Academy of Sciences, 2010

Research interests: 
1.  Natural bioactive peptides/proteins discovery
2. Bioactive peptides/proteins design
3. Bioactive peptides/proteins application
Representative publications:
1.         Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. Cai, S.; et. al. J Med Chem. 2018 Feb 21. doi: 10.1021/acs.jmedchem.8b00036.

2.         As-CATH4 and 5, two vertebrate-derived natural host defense peptides, enhance the immuno-resistance efficiency against bacterial infections in Chinese mitten crab, Eriocheir sinensis. Guo, Z.; et. al. Fish Shellfish Immunol. 2017 71:202-209.

3.         Novel cathelicidins with potent antimicrobial, biofilm inhibitory, and anti-inflammatory activities from the frog Fejervarya multistriata. Wang, A.; et. al. Asian Herpetol Res. 2017 8(3):199-212.

4.         As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host anti-microbial immune responses. Chen, Y.; et. al. Biochem J. 2017 474:2861-2885.

5.         Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability. Yu, H.; et. al. Sci Rep. 2017 1;7(1):2600.

6.         Identification, eukaryotic expression and structure & function characterizations of β-defensin like homologues from Pelodiscus sinensis. Yu, H.; et. al. Dev Comp Immunol. 2017 68:108-117.

7.         Express sequence tag analysis-identification of anseriformes trypsin genes from full-length cDNA library of the duck (Anas platyrhynchos) and characterization of their structure and function. Yu, H.; et. al. Biochemistry (Moscow) 2016 81(2): 152-162.

8.         Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms. Yu, H.; et. al. Biochimie. 2016 121: 268-277.

9.         Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity, and Special Mechanism. Wei, L.; et. al. J Biol Chem. 2015 290(27): 16633-52. (Highlighted by Chem Res Toxicol)

10.      Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity. Yu, H.; et. al. Sci Rep. 2015 21;5:11082.

11.      Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. Ling, G.; et. al. PLoS. ONE. 2014, 27, 9(3):e93216. (Corresponding author)

12.      Identification and polymorphism discovery of the cathelicidins, Lf-CATHs in ranid amphibian (Limnonectes fragilis). Yu, H.; et. al. FEBS. J. 2013, 280, 6022-6032. (Corresponding author)

13.      Structural and functional characterization of CATH_BRALE, the defense molecule in the ancient salmonoid, Brachymystax lenok. Li, Z.; et. al. Fish. Shellfish. Immunol. 2013, 34, 1-7. (Corresponding author)

14.      Host defense peptides in skin secretions of Odorrana tiannanensis: proof for other survival strategy of the frog than merely antimicrobial. He, W.; et. al. Biochimie. 2012, 94, 649-655. (Corresponding author)

15.      Hainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis. Zhang, S.; et. al. Peptides. 2012, 33, 251-257. (Corresponding author)

16.      Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. Wang, Y.; et. al. PLoS. ONE. 2011, 6(7):e22120.

17.      Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianus colchicus. Wang, Y.; et. al. Dev. Comp. Immunol. 2011, 35, 314-322.

18.   Two immunoregulatory peptides with antioxidant activity from tick salivary glands. Wu, J.; et. al. J. Biol. Chem. 2010, 285, 16606-16613. (Co-first author)

19.      Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Ma, D.; et. al. Mol. Cell. Proteomics. 2009, 8, 2071-2079. (Co-first author)

20.      Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. Wang, Y.; et. al. PLoS. ONE. 2008, 16, 3(9):e3217.


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