Medicinal Chemistry
 
Synthesis and Evaluation of Photosensitizer
Hui He
Associate Professor
B.S. Jiangxi Normal University, 2002
M.S. Xiamen University, 2005
Ph.D. The Chinese University of Hong Kong, 2010
hhe@suda.edu.cn
 

Research interests:
1. Design and synthesis of smart photosensitizer s for photodynamic therapy
2. Design and synthesis of smart fluorescent probes for bio-imaging
Representative publications:
1. He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. Chem. Eur J. 2014, 20, in press. (DOI: 10.1002/chem.201400001)
2. Wan, Z.; Mao, H.; Guo, M.; Li, Y.; Zhu, A.; Yang, H.; He, H.; Shen, J.; Zhou, L.; Jiang, Z.; Ge, C.; Chen, X.; Yang, X.; Liu, G.; Chen, H. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics 2014, 4, 399-411.
3. Guo, M.; Mao, H.; Li, Y.; Zhu, A.; He, H.; Yang, H.; Wang, Y.; Tian X.; Ge, C.; Peng, Q.; Wang, X.; Yang, X.; Chen, X.; Liu, G.; Chen, H. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials 2014, 35, 4656-4666.
4. He, H.; Ng, D. K. P. Differential detection of Zn2+ and Cd2+ ions by BODIPY-based fluorescent sensors. Chem. Asian J. 2013, 8, 1441-1446.
5. He, H.; Liu, J.-Y.; Ng, D. K. P. A phthalocyanine-based fluorescent sensor for Zn2+ ion. J. Porphyrins Phthalocyanines 2013, 17, 99-103.
6. He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis and in vitro photodynamic activities of pegylated distyryl BODIPY derivatives. J. Med. Chem. 2011, 54, 3097-3102.
7. He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties. Chem. Commun. 2011, 47, 4748-4750.
8. He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY. Org. Biomol. Chem. 2011, 9, 2610-2613.
9. Li, A.-F.; He, H.; Ruan, Y.-B.; Wen, Z.-C.; Zhao, J.-S.; Jiang, Q.-J.; Jiang, Y.-B. Oxidative cyclization of N-acylhydrazones. Development of highly selective turn-on fluorescent chemodosimeters for Cu2+. Org. Biomol. Chem. 2009, 7, 193-200.
10. Wen, Z.-C.; Yang, R.; He, H.; Jiang, Y.-B. A highly selective charge transfer fluoroionophore for Cu(II). Chem. Commun. 2006, 106-108.

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