Medicinal Chemistry
 
Synthesis and Evaluation of Photosensitizer
Hui He
Associate Professor
B.S. Jiangxi Normal University, 2002
M.S. Xiamen University, 2005
Ph.D. The Chinese University of Hong Kong, 2010
hhe@suda.edu.cn
 

Research interests:
 

1.    Design and synthesis of ‘smart’ responsive photosensitizers for phototherapy

2.    Self-assembled nano-sized photosensitizers for tumor diagnosis and therapy

 

Representative publications:

 

1.    Ye, S.; Rao, J.; Qiu, S.; Zhao, J.; He, H.*; Yan, Z.; Yang, T.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.*; Chen, H.* Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy. Adv. Mater. 2018, DOI: 10.1002/adma.201801216.

2.    He, H.#; Ji, S.#; He, Y.; Zhu, A.; Zou, Y.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.; Chen, H. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-Induced cancer therapy. Adv. Mater. 2017, 29, 1606690.

3.    Guo, Z.#; Zou, Y.#; He, H.#; Rao, J.; Ji, S.; Cui, X.; Ke, H.; Deng, Y. Yang, H.; Chen, C.; Zhao, Y.; Chen, H. Bifunctional platinated nanoparticles for photoinduced tumor ablation. Adv. Mater. 2016, 28, 10155-10164.

4.    He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. Chem. Eur J. 2014, 20, 6241-6245.

5.    He, H.; Ng, D. K. P. Differential detection of Zn2+ and Cd2+ ions by BODIPY-based fluorescent sensors. Chem. Asian J. 2013, 8, 1441-1446.

6.    He, H.; Liu, J.-Y.; Ng, D. K. P. A phthalocyanine-based fluorescent sensor for Zn2+ ion. J. Porphyr. Phthalocya. 2013, 17, 99-103.

7.    He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis and in vitro photodynamic activities of pegylated distyryl BODIPY derivatives. J. Med. Chem. 2011, 54, 3097-3102.

8.    He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties. Chem. Commun. 2011, 47, 4748-4750.

9.    He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY. Org. Biomol. Chem. 2011, 9, 2610-2613.

 

Research Support

1.    Design and synthesis of pH-activatable and tumor-targeted photosensitizers for photodynamic therapy, National Natural Science Foundation of China (2015-2017)

2.    Targeted and activatable photosensitizers for tumor imaging and photodynamic therapy, Natural Science Foundation of Jiangsu Province (2015-2017)

3.    Synthesis of tumor-targeted photosensitizers based on boron dipyrromethenes for photodynamic therapy, Natural Science Foundation for Colleges and Universities in Jiangsu Province (2014-2016)

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