Medicinal Chemistry
 
Drug Design, Synthesis and Evaluation
Chunhua Qiao
Professor
B.S. Northeast Normal University, 1993
Ph.D. Case Western Reserve University, USA, 2004
qiaochunhua@suda.edu.cn
 

Research interests
1.  Anti-parasite drug design, synthesis and evaluation
2.  Anti-cancer drug development
3.  Monoclonal antibody development for small molecular detection
Professional Experience
2008-         Professor, College of Pharmaceutical Science, Soochow University
2005-2007 Research Assistant, Center for Drug Design,  University of Minnesota, USA
2004-2005 Postdoctoral Research Fellow, University of Michigan, USA
Teaching
Undergraduates: Organic Chemistry, Medicinal Chemistry
Graduates:          Advances in Medicinal Chemistry
Representative publications:
1. Jing Yang, Yanli Liu, Chengwen Xue, Wei Yu, Jian Zhang, Chunhua Qiao* Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents European Journal of Medicinal Chemistry 2014, 86, 235-241
2. Lili Wang, Ying-Ying Zhang, Lei Wang, Feng-you Liu, Ling-Ling Cao, Jing Yang, Chunhua Qiao,* Yonghao Ye,* Benzofurazan derivatives as antifungal agents against phytopathogenic fungi European Journal of Medicinal Chemistry, 2014, 80, 535-542
3. Zhixiang Xu, Wei Yin, Leonardo K. Martinelli, Joanna Evans, Jinglei Chen, Yang Yu   Daniel J. Wilson, Valerie Mizrahi, Chunhua Qiao*, Courtney C. Aldrich*  Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase Bioorganic & Medicinal Chemistry, 2014, 22, 1726-1735.
4. Shu-hua Xiao, Chunhua Qiao, Jian Xuea, Lili Wang Mefloquine in combination with hemin causes severe damage toadult Schistosoma japonicum in vitro. Acta Tropica 2014, 131, 71-78
5. Lili Wang, Cong Li, Yingying Zhang, Chunhua Qiao*, Yonghao Ye, Synthesis and biological evaluation of benzofuroxan derivatives as fungicides against phytopathogenic fungi, J. Agric. Food Chem. 2013, 61(36), 8632-8640.
6. Zhi-xia Wang, Jing-lei, Chen, Chunhua Qiao*, Praziquantel derivatives with antischistosomal activity: aromatic ring modification. Chemical Biology & Drug Design, 2013, 82, 2, 216-225.
7. Jinglei Chen, Weizhen Sun, Jingjing Yang, Huan Sun, Zhixia Wang, Lanlan Dong, Chunhua Qiao,* Chao-ming Xia,*  Development of a novel class of pyrrolo-[1,2,5]benzothiadiazepine derivatives as potential anti-schistosomal agents Bioorg. Med. Chem. Lett. 2013, 23, 3785-3787
8. Xing Yan, Chunhua Qiao*, Zhong-Wu Guo Tin (IV) chloride promoted reaction of oxiranes with hydrogen peroxide SYNLETT. 2013, 24, 0502-0506. 
9. Jian-zhong Wu, Zhixia Wang, Chunhua Qiao* Synthesis of Stagonolide C from Mulzer Epoxide Tetrahed Lett. 2012, 53, 1153-1155.
10. Wenwen, D.; Sijie, Q.; Yue, Z.; Chunhua, Qiao;* Chaoming, Xia*.; “Praziquantel Derivatives Exhibit Activity against both Juvenile and Adult Schistosoma japonicum” Bioorg.Med.Chem.Lett. 2012, 22, 1587-1590
11. Zhaoli Zhang, Jinglei Chen, Qiongming Xu,Chunhua Qiao* Efficient Synthesis of Hydroxytyrosol from 3,4-Dihydroxybenzaldehyde. Synth. Commun. 2012, 42, 6, 794-798
12. Huan-qiu, Li, Jing Yang, Shuhua Ma, Chunhua Qiao*, Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein Bioorg. Med. Chem. 2012, 20, 4194-4200
13. XingYan, Jinglei Chen, Chunhua Qiao* Phosphomolybdic Acid Catalyzed  Synthesis of 1,2,4,5-Tetraoxanes, SYNLETT. 2011, 19, 2827-2830.
14. Wei Yin, Chunhua Qiao* Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactone,J. Heterocycl. Chem  In press.
15. Huan-Qiu Li*, Yin Luo,Chunhua Qiao* The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone Mini-Review  Med. Chem.  2012,12,4,350-362
16. Chunhua Qiao, Amol Gulpte, Helena Boshoff, Daniel J. Wilson, Eric  Bennett,Clifton E. Barry III, and Courtney C. Aldrich, “5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins. J. Med.Chem. 2007, 50, 6080-6094.  
17. Chunhua Qiao, Daniel J. Wilson, Eric Bennett, and Courtney C. Aldrich, “A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe” J. Am. Chem. Soc. 2007, 129, 6350-6351
18 Chunhua Qiao, Ke-Qing Ling, Eric M. Shepard, David M. Dooley, and Lawrence M. Sayre,   “Mechanism-Based Cofactor Derivatization of a Copper Amine Oxidase by a Branched Primary Amine Recruits the Oxidase Activity of the Enzyme to Turn Inactivator into Substrate” J. Am. Chem. Soc.  2006, 128, 6206-6219
19. Ravindranadh Somu, Helena Boshoff, Chunhua Qiao, Eric Bennett, Clifton E. Barry III, and Courtney C. Aldrich, “Rationally Designed Nucleoside Antibiotics that Inhibit Siderophore Biosynthesis of Mycobacterium tuberculosis” J. Med. Chem. 2006, 49, 31-34.
20. Miri Yoon, Anjali Patwardhan, Chunhua Qiao, Steven O. Mansoorabadi, Ann L. Menefee, George H. Reed, and E. Neil G. Marsh, “Reaction of Adenosylcobalamin-Dependent Glutamate Mutase with 2-Thiolglutarate” Biochemistry, 2006, 45, 11650-11657
21. Chunhua Qiao, and E. Neil G. Marsh, “Mechanism of Benzylsuccinate Synthase: Stereochemistry of Toluene Addition to Fumarate and Maleate” J. Am. Chem. Soc. 2005, 127, 8608-8609
22. Chunhua Qiao, Heung-Bae Jeon, and Lawrence M. Sayre, “Selective Inhibition of Plasma Amine Oxidase by Homopropargylamine, a New Inactivator Motif” J. Am. Chem. Soc. 2004, 126, 8038-8045
23. Zbynek Lamplot, Marek Sebela, Michal Malon, Rene Lenobel, Karel Lemr, Jan Havlis, Pavel Pec, Chunhua Qiao, Lawrence M. Sayre,   “1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases”    Eur. J. Biochem., 2004, 271(23/24) ,  4696-4708
24. Heung-Bae Jeon, Younghee Lee, Chunhua Qiao, He Huang, and Lawrence M. Sayre, “Inhibition of Bovine Plasma Amine Oxidase by 1,4diamino2butenes and 2butynes” Bioorg. Med. Chem., 2003, 11, 4631-4641

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