Medicinal Chemistry
Chemical Biology and Drug Discovery
Feng Liu
Associate Professor
B.S. Xiamen University, 2003
Ph.D. Shanghai Institute of Organic Chemistry, 2009

Research interests:
1. Design and synthesis of small molecule modulators targeting epigenetic enzymes
2. Therapeutics targeting cancer and neural diseases related to epigenetic malfunctions
Representative Publications:
1. An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1.  Konze, K. D.; et. al. ACS Chemical Biology, 2013, 8, 1324.
2. Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors. Liu, F.; et. al.J. Med. Chem. 2013, 56, 2110.
3. An Allosteric Inhibitor of Protein Arginine Methyltransferase 3. Siarheyeva, A. et. al. Structure 2012, 20, 1425.
4. Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines. Liu, F.; et. al. J. Med. Chem. 2011, 54, 6139.
5.Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code”. Yost, J. M.; Korboukh, I.; Liu, F.; Gao, C.; Jin, J. * Curr.Chem.Genomics. 2011, 5, 72.
6. A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells. Vedadi, M#.; Barsyte-Lovejoy, D#.; Liu, F#.; et. al. Nature Chem. Biol.2011, 7, 566. ( co-first author)
7. Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines. Liu, F.; et. al. J. Med. Chem. 2010, 53, 5844.
8. Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a. Liu, F.; et. al. J. Med. Chem. 2009, 52, 7950.

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