Medicinal Chemistry
 
Chemical Biology and Drug Discovery
Feng Liu
Associate Professor
B.S. Xiamen University, 2003
Ph.D. Shanghai Institute of Organic Chemistry, 2009
Postdoc, UNC at Chapel Hill, 2012
fliu2@suda.edu.cn
Office: +86-512-65882569
 

Research interests: 

1)      Design and synthesis of small molecule modulators targeting epigenetic enzymes.

2)      Therapeutics targeting cancer and neural diseases related to epigenetic malfunctions.

3)      Development of new synthetic methodology and its utility in drug discovery.
Representative Publications:
 

1)       Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.; Liu, F.*; Vedadi, M.*; Liu, J.*; Jin, J.* Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). J. Med. Chem. 2018, 61, 1541-1551.

2)       Kaniskan, H. Ü.; Eram, M. S.; Zhao, K.; Szewczyk, M. M.; Yang, X.; Schmidt, K.; Luo, X.; Xiao, S.; Dai, M.; He, F.; Zang, I.; Lin, Y.; Li, F.; Dobrovetsky, E.; Smil, D.; Min, S.-J.; Lin-Jones, J.; Schapira, M.; Atadja, P.; Li, E.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P. J.; Liu, F.*; Yu, Z.*; Vedadi, M.*; Jin, J.* Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J. Med. Chem. 2018, 61, 1204-1217.

3)       Liu, J.-L.; Zhu, Z.-F.; Liu, F.* Oxycyanation of Vinyl Ethers with 2,2,6,6-Tetramethyl-N-oxopiperidinium Enabled by Electron Donor-Acceptor Complex. Org. Lett. 2018, 20, 720-723.

4)       Wu, S.-W.; Liu, J.-L.; Liu, F.* cis-Specific cyanofluorination of vinyl azides enabled by electron-donor-acceptor complexes: synthesis of a-azido-ß-fluoronitriles. Chem. Commun. 2017, 53, 12321-12324.

5)       Fang, J.; Wang, Z.-K.; Wu, S.-W.; Shen, W.-G.; Ao, G.-Z.; Liu, F.* Photoredox-catalysed chloro-, bromo- and trifluoromethylthiotrifluoromethylation of unactivated alkenes with sodium triflinate. Chem. Commun. 2017, 53, 7638-7641.

6)       Qin, H.-T.; Wu, S.-W.; Liu, J.-L.; Liu, F.* Photoredox-Catalysed Redox-Neutral Trifluoromethylation of Vinyl Azides for the Synthesis of a–Trifluoromethylated Ketones. Chem. Commun. 2017, 53, 1696-1699.

7)       Wu, S.-W.; Liu, F.* Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation. Org. Lett. 2016, 18, 3642-3645.

8)       Wu, S.-W.; Liu, J.-Li.; Liu, F.* Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins. Org. Lett. 2016, 18(1): 1-3.

9)       Dong, K.; Qin, H.; Bao, X.; Liu, F.*; Zhu, C.* Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin. Org. Lett. 2014, 16(20): 5266-5268.

10)   Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Xiong, Y.; Korboukh, V.; Huang, X. P.; Allali-Hassani, A.; Janzen, W. P.; Roth, B. L.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Vedadi, M.; Jin, J. Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP. J. Med. Chem. 2013, 56, 8931-8942.

11)   Liu, F.; Li, F.; Ma, A.; Dobrovetsky, E.; Dong, A.; Gao, C.; Korboukh, I.; Liu, J.; Smil, D.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Schapira, M.; Vedadi, M.; Jin, J. Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors. J. Med. Chem. 2013, 56, 2110-2124.

12)   Vedadi, M#.; Barsyte-Lovejoy, D#.; Liu, F#.; Rival-Gervier, S.; Allali-Hassani, A.; Labrie, V.; Wigle, T. J.; DiMaggio, P. A.; Wasney, G. A.; Siarheyeva, A.; Dong, A.; Tempel, W.; Wang, S.-C.; Chen, X.; Chau, I.; Mangano, T.; Huang, X.-P.; Simpson, C. D.; Pattenden, S. G.; Norris, J. L.; Kireev, D. B.; Tripathy, A.; Edwards, A.; Roth, B. L.; Janzen, W. P.; Garcia, B. A.; Petronis, A.; Ellis, J.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Jin, J. A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells. Nature Chem. Biol. 2011, 7, 566-574. (Highlighted by News and Views: Nature Chemical Biology, 2011, 7, 499-500.)

13)   Liu, F.; Barsyte-Lovejoy, D.; Allali-Hassani, A.; He, Y.; Herold, J. M.; Chen, X.; Yates, C. M.; Frye, S. V.; Brown, P. J.; Huang, J.; Arrowsmith, C. H.; Jin, J. Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines. J. Med. Chem. 2011, 54, 6139-6150.

14)   Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wigle, T. J.; Wasney, G. A.; Dong, A.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Norris, J. L.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Janzen, W. P.; Arrowsmith, C. H.; Frye, S. V.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines. J. Med. Chem. 2010, 53, 5844-5857.

15)Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a. J. Med. Chem. 2009, 52, 7950-7953.

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