Medicinal Chemistry
 
Drug Design, Interface of Organic Chemistry and Biology
Huanqiu Li
Associate Professor
B.S. Jilin University, Changchun, China 2000-2004
M.S. & Ph.D. Nanjing University, China 2004-2008
Postdoc Nanjing University, China 2008-2010
Visiting Scholar University of New Mexico, USA, 2014-2015
huanqiuli@suda.edu.cn
 

Research Interest:
1. Research at the interface of organic chemistry and biology based on the synthesized compounds with potent biological activity.
2. Using the latest methods of organic synthesis combined with information gleaned from the computer-aided molecular design modeling.

Representative Publications:
1. Epidermal Growth Factor Receptor (EGFR) inhibitors: a patent review (2010 - present). Li, H.Q.;* et.al. Expert. Opin. Ther. Patents. 2014, 24, 309-321.
2. Novel FabH inhibitors: a updated article literature review (July 2012 to June 2013). Li, H.Q.;* et.al. Expert. Opin. Ther. Patents. 2014, 24, 19-27.
3. Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity. Li, H.Q.;* et.al. Bioorg. Med. Chem. 2013, 21, 6084-6091.
4. Design, synthesis and molecular docking of alphaβ-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferativeactivity. Li, H.Q.;* et.al. Bioorg. Med. Chem. 2013, 21, 388-394.
5. The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone. Li, H.Q.;* et.al. Mini-Rev. Med. Chem, 2012, 12, 350-362. 
6. Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity. Li, H.Q.;* et.al. Bioorg. Med. Chem. 2012, 20, 317-323.
7. Metronidazole-Deoxybenzoin Derivatives as Anti-Helicobacter pylori Agents with Potent Inhibitory Activity against HPE Induced Interleukin-8. Li, H.Q.; et.al. ChemMedChem. 2010, 5, 1110-1116. 
8. Design, Synthesis and Immunosuppressive Activity of New Deoxybenzoin Derivatives. Li, H.Q.; et.al. ChemMedChem. 2010, 5, 1117-1122. 
9. Design and Synthesis of Novel Deoxybezoin Derivatives as FabH inhibitors and Anti-inflammatory Agents. Li, H.Q.; et.al. Bioorg. Med. Chem. Lett. 2010, 20, 2025-2028. 
10. Amines and oximes derived from deoxybenzoins as Helicobacter pylori urease inhibitors. Li, H.Q.; et.al. Eur. J. Med. Chem. 2009, 44, 2246-2251.

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