Neurospychopharmacology & CNS Drug Discovery
Xuechu Zhen
Ph.D. University of Geneva, 1996

Research interests
1. Neurotransmission regulation, especially dopamine and serotonin in physiology and diseases
2. CNS drug discovery, especially Parkinson’s disease, Schizophrenia and drug addiction
3. Microglia in neuropsycho-disorders
Invited Reviews
1. Chu HY, Zhen X. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems. Acta Pharmacol Sin. 2010 Sep; 31(9):1036-43.
2. Zhang J, Xiong B, Shen JK, Zhen X, Zhang A. Dopamine D1 Receptor Ligands: Where are we now and where are we going?  Med. Res. Rev. 2009 Mar; 29(2):272-94.
3. Chu HY, Jin GZ, Friedman E, Zhen X. Recent Development in Studies of Tetrahy droprotoberberines: Mechanism in Antinociception and Drug Addiction. Cell Mol Neurobiol. 2008 Jun; 28(4):491-9.
4. Mo J, Guo Y, Yang YS, GZ Jin, Zhen X. A novel dual dopamine D1 receptor agonist and D2 receptor antagonist: potential antipsychotic agents. Current Medical Chemistry. 2007, 14:2996-3002.
5. Ye N, Neumeyer JL, Baldessarini RJ, Zhen X, Zhang A.Update 1 of: Recent Progress in Development of Dopamine Receptor Subtype-Selective Agents: Potential Therapeutics for Neurological and Psychiatric Disorders. Chem Rev. 2013 May 8;113(5):PR123-78
6. Xu L, Li Y, Sun H, Zhen X, Qiao C, Tian S, Hou T. Current developments of macrophage migration inhibitory factor (MIF) inhibitors. Drug Discov Today. 2013 Jun;18(11-12):592-600.
Research Papers (Selected)
1. Mu Y,  Ren Z, Jia J, Gao B, Zheng L-T, Wang G,  Friedman E,  Zhen X. Inhibition of Phosphodiesterase10A Attenuates Morphine-Induced Conditioned Place Preference. Mol Brain, accepted.
2. Zhang J, Huang J, Song Z, Guo L, Cai W, Wang Y, Zhen X, Zhang A. Structural manipulation on the catecholic fragment of dopamine D1 receptor agonist 1-phenyl-N-methyl-benzazepines. Eur J Med Chem. 2014 Jul 24;85C:16-26
3. Tao L, Zhang F, Hao L, Wu J, Jia J, Liu JY, Zheng LT, Zhen X. 1-O-Tigloyl-1-O-deacetylnimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells. J Pharmacol Sci. 2014 Jul 11. [Epub ahead of print]
4. Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. (6aR)-11-Amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease. Pharmacol Biochem Behav. 2014 Jun 21;124C:204-210.
5. Li L, Liu S, Lei Y, Cheng Y, Yao C, Zhen X. Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2. J Neurosci Res. 2014 Jul;92(7):835-46.
6. Zhou SL, Chu HY, Jin GZ, Cui JM, Zhen XC. Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study. Acta Pharmacol Sin. 2014 Jun;35(6):738-51.
7. Zheng J, Yang Z, Li X, Li L, Ma H, Wang M, Zhang H, Zhen X, Zhang X. Optimization of 6-Heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as Potent Adenosine A2A Receptor Antagonists for the Treatment of Parkinson's Disease. ACS Chem Neurosci. 2014 Jun 23. [Epub ahead of print]
8. Jin Q, Cheng J, Liu Y, Wu J, Wang X, Wei S, Zhou X, Qin Z, Jia J, Zhen X. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immun. 2014 1591(14)00069-5.
9. Zhou X, Cao Y, Ao G, Hu L, Liu H, Wu J, Wang X, Jin M, Zheng S, Zhen X, Alkayed NJ, Jia J, Cheng J. CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation. Antioxid Redox Signal. 2014 Mar 13. [Epub ahead of print]
10. Zhang Z, Hao CJ, Li CG, Zang DJ, Zhao J, Li XN, Wei AH, Wei ZB, Yang L, He X, Zhen XC, Gao X, Speakman JR, Li W. Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons. PLoS Genet. 2014 Feb 13;10(2):e1004124
11. Yang Z, Li X, Ma H, Zheng J, Zhen X, Zhang X. Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists. Bioorg Med Chem Lett. 2014 Jan 1;24(1):152-5.
12. Yang YX, Zheng LT, Shi JJ, Gao B, Chen YK, Yang HC, Chen HL, Li YC, Zhen X. Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: discovery of a novel neuroinflammation inhibitor. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1222-7.
13. Xu L, Zhang Y, Zheng L, Qiao C, Li Y, Li D, Zhen X, Hou T. Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays. J Med Chem. 2014 May 8;57(9):3737-45.
14.  Guo L, Zhao J, Jin G, Zhao B, Wang G, Zhang A, Zhen X. SKF83959 is a Potent Allosteric Modulator of Sigma-1 Receptor. Mol Pharmacol. 2013 ;83(3):577-86
15. Zhang L, Fan H, Lu R, Xin Y, Zhen X, Liu Z. CMYA5: a new potential substrate of Kcna3 in human heart. Biochem Biophys Res Commun. 2013 45(3):236-8
16. Mao L, Jia J, Zhou X, Xiao Y, Wang Y, Mao X, Zhen X, Guan Y, Alkayed NJ, Cheng J. Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. Neuroscience. 2013 Feb 12;231:272-81
17. Fang X, Guo L, Jia J, Jin GZ, Zhao B, Zheng YY, Li JQ, Zhang A, Zhen XC. SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity. Acta Pharmacol Sin. 2013 Sep;34(9):1149-55.
18. Xu L, Zhou S, Yu K, Gao B, Jiang H, Zhen X, Fu W. Molecular modeling of the 3D structure of 5-HT(1A)R: discovery of novel 5-HT(1A)R agonists via dynamic pharmacophore-based virtual screening. J Chem Inf Model. 2013 Dec 23;53(12):3202-11.
19. Guan YT, Mao LL, Jia J, Dong CS, Zhou XM, Zheng SL, Liu H, Kong HM, Zhen XC, Cheng J. Postischemic administration of a potent PTEN inhibitor reduces spontaneous lung infection following experimental stroke. CNS Neurosci Ther. 2013 Dec;19(12):990-3.
20. Du P, Xu L, Huang J, Yu K, Zhao R, Gao B, Jiang H, Zhao W, Zhen X, Fu W. Design, synthesis, and evaluation of indolebutylamines as a novel class of selective dopamine D3 receptor ligands. Chem Biol Drug Des. 2013 Sep;82(3):326-35.
21. Jia J, Xiao Y, Wang W, Qing L, Xu Y, Song H, Zhen X, Ao G, Alkayed NJ, Cheng J. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8.
22. Sun H, Zhu L, Yang H, Qian W, Guo L, Zhou S, Gao B, Li Z, Zhou Y, Jiang H, Chen K, Zhen X, Liu H. Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. Bioorg Med Chem. 2013 Feb 15;21(4):856-68.
23. Mao L, Jia J, Zhou X, Xiao Y, Wang Y, Mao X, Zhen X, Guan Y, Alkayed NJ, Cheng J. Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. Neuroscience. 2013 Feb 12;231:272-81
24. Ren H, Fu K, Mu C, Zhen X, Wang G. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 2012 Aug 14;7:40.
25. Liu CL, Gao M, Jin GZ, Zhen X. GABA Neurons in the Ventral Tegmental Area Responding to Peripheral Sensory Input. PLoS One. 2012;7(12):e51507. doi: 10.1371.
26. Qian W, Lu W, Sun H, Li Z, Zhu L, Zhao R, Zhang L, Zhou S, Zhou Y, Jiang H, Zhen X, Liu H. Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D receptor. Bioorg Med Chem. 2012, 20(15):4862-71.
27. Zhang CL, Feng ZJ, Liu Y, Ji XH, Peng JY, Zhang XH, Zhen XC, Li BM. Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action. PLoS One. 2012;7(12):e51910.
28. Zheng YY, Guo L, Zhen XC, Li JQ. Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors. Eur J Med Chem. 2012, 54:123-36.
29. Xu Z, Dong S, Du D, Jiang N, Sun P, Wang H, Yin L, Zhang X, Cao X, Zhen X, Hu Y. Generation and characterization of hD(5) and C-terminal Mutant hD(5m) transgenic rats. Brain Res. 2012, 1448:27-41.
30. Zhang CL, Feng ZJ, Liu Y, Ji XH, Peng JY, Zhang XH, Zhen XC, Li BM. Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action. PLoS One. 2012;7(12):e51910.
31. Chu HY, Wu Q, Zhou S, Cao X, Zhang A, Jin GZ, Hu GY, Zhen X. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. J Neurosci Res. 2011 Aug;89(8):1259-66.
32. Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D(3) receptor ligands. Bioorg Med Chem. 2011 Mar 15; 19(6):1999-2008.
33. Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Identification of N-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson's Agent Possessing a Dopamine D(2) and Serotonin 5-HT(1A) Dual-Agonist Profile. J Med Chem. 2011 Jun 14. 54(13):4324-38.
34. Chu HY, Yang Z, Zhao B, Jin GZ, Hu GY, Zhen X. Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro. Brain Res. 2010 Jul 9; 1343:20-7.
35. Mo J, Zhang H, Yu LP, Sun PH, Jin GZ, Zhen X. L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neurobiol Aging. 2010 Jun; 31(6):926-36.
36. Chu HY, Gu QH, Jin GZ, Hu GY, Zhen X. Electrophysiological Effects of SKF83959 on Hippocampal CA1 Pyramidal Neurons: Potential Mechanisms for the Drug’s Neuroprotective Effects. PlosOne. 2010 Oct 1; 5(10): e13118.
37. Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen X. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse.2011 May; 65(5):379-87.
38. Zhao T, Liu X, Zhen X, Guo SW. Levo-Tetrahydropalmatine (l-THP) Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats. Reprod Sci. 2011 Jan; 18(1):18-45.
39. Wu C, Yang K, Liu Q, Wakui M, Jin GZ, Zhen X, Wu J. Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta. Neuropharmacology. 2010 Dec; 59(7-8):567-72.
40. Liu Z,Zhang H, Yu LP, Zhen X, Zhang A. Synthesis of Furo[3,2-l]aporphine and Dihydrofuro[3,2-l]aporphine Derivatives: Identification of a Potent and Selective 5-HT1A Receptor Agonist. J. Med. Chem. 2010 Feb 11; 53(3):1319-28.
41. Zhang J, Zhang H, Cai W, Yu L, Zhen X, Zhang A. 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. Bioorg Med Chem.2009 Jul 15; 17(14):4873-80.
42. Zhang X, Zhou Z, Wang D, Li A, Yin Y, Gu X, Ding F, Zhen X, Zhou J. PI-linked D1 receptor-Mediated FGF-2 Expression in Astrocytes Protects Dopaminergic Neurons. J. Neurosci. 2009, 29(24):7766-75.
43. Guo Y, Zhang H, Chen X, Cai W, Cheng J, Yang Y, Jin G, Zhen X*. Evaluation of the a antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. Schizophrenia Res. 2009 Nov; 115(1):41-9.
44. Sun P, Wang J, Gu W, Cheng W, Jin GZ, Friedman E, Zheng J, Zhen X. PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation. Cell Res. 2009 May; 19(5):612-24.
45. Chen XQ, Zhang J, Neumeyer JL, Jin GZ, Hu GY, Zhang A, Zhen X*. Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoSOne. 2009 Jun 5; 4(6):e5811.
46. Yang K, Hu J, Lucero L, Liu Q, Zheng C, Zhen X, Jin G, Lukas RJ, Wu J. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol. 2009 Jan 15; 587(Pt 2):345-61.
47. Liu Z, Chen X, Yu L, Zhen X, Zhang A. Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15; 16(14):6675-81.
48. Liu Z, Chen X, Sun P, Yu L, Zhen X, Zhang A. N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15; 16(18):8335-8.
49. Zhang D, Zhang H, Jin GZ, Zhang K, Zhen X. Single dose of morphine produced a prolonged effect on dopamine neuron activities. Mol Pain. 2008 Nov 17; 17: 4-57.
50. Zhang D,  Yang S,  Yang C,  Jin G,  Zhen X. Estrogen modulated cocaine-altered dopamine neuron activity in ventral tegmental area. Psychopharmacology. 2008, 199(4):625-35.
51. Mo J, Zhang H, GZ Jin, Zhen X. SPD attenuated L-DOPA-induced dyskinesia in Parkinsons disease rat model. Neurobiolgy of aging. 2010 Jun; 31(6):926-36.
52. Zhang J, Chen X, Yu L, Zhen X, Zhang A. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities. Bioorg Med Chem. 2008 Nov1; 16(21):9425-31.
53. Feng YQ, Zhou ZY, He X, Wang H, Guo XL, Hao CJ, Guo Y, Zhen X, Li W. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia. Schizophr Res. 2008 Dec; 106(2-3):218-28.
54. Zhang ZJ, Tan QR, Tong Y, Li Q, Kang WH, Zhen X, Post RM. The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled study. J Affect Disord. 2008 Jul; 109(1-2):91-7.
55. Yu Y, Wang JR, Sun PH, Guo Y, Zhang ZJ, Jin GZ, Zhen X. Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3beta and a receptor-independent anti-oxidative action. J Neurochem. 2008 Feb; 104(4):946-56.
56. Gu WH, Yang S, Shi WX, Jin GZ, Zhen XC. Requirement of PSD-95 for dopamine D1 receptor modulating glutamate NR1a/NR2B receptor function. Acta Pharmacol Sin. 2007 Jun; 28(6):756-62.
57. Tan QR, Wang XZ, Wang CY, Li XJ, ChenY,Wang HH,Zhen X and Zhang ZJ. Differential effects of atypical and classical antipsychotics in protecting against neurotoxicity induced by rotenone in PC12 cells.  Eur Neuropsychopharmacol. 2007, 17(12):768-73.
58. Zhen X, Goswami S, Abdali SA, Frankfurt M, Friedman E. Estrogen-modulated frontal cortical CaMKII activity and behavioral supersensitization induced by prolonged cocaine treatment in female rats. Psychopharmacology (Berl). 2007 Apr; 191(2):323-31.
59. Zhang H, Wang F, Chen J, Zhen X. SKF83959 attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson’s disease. Neuropharmacology. 2007 Jul; 53(1):125-33.
60. GU W, Shi WX, Zhen X,  Jin G. Effects of (-) -stepholidineon NMDA receptors; comparison with haloperidol and clozapine. Acta Pharmacologica Sinica. 2007 Jul; 28(7):953-8.
61. Gu W, Shi WX,  Jin G, Zhen X. Requiring PSD-95 for D1 dopamine receptor modulating NMDA receptor function. Acta Pharmacologica Sinica. 2007, 28(6):756-62.
62. Gao M, Liu CL, Yang S, Zhen X, Jin GZ. l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. Acta Pharmacol Sin. 2007 May; 28(5):627-33.
63. Ming Y, Zhang H, Long L, Wang F, Chen J, Zhen X. Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons. J Neurochem. 2006 Aug; 98(4):1316-23.
64. Zhen X, S Gaswomi, E Friedman. Estrogen-modulated frontal cortical CaMKII activity is involved in behavioral supersensitization to cocaine in female rats. Psychopharmacology. 2007 Apr; 191(2):323-31.
65. Yuling Ming, Hai Zhang, J Chen, Zhen X. SKF83959 stimulates Ca2+ signaling in primary cultured hippocampal neurons. J. Neurochem. 2005, 98:1316-23.
66. Zhang-Jin Zhang, Xiao-Long Jiang, Steven E. Zhang, Yan Zhang, Christopher J. Hough, He Li, Zhen X. The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm. Neurosci. Lett.2005 Jul; 382(1-2):134-8.
67. Zhen X, Satindra Goswami. Activation of Phosphatidyinositol (PI)-linked D1 Dopamine Receptor Is Associated With The Antiparkinsonian Action of SKF83959. Biochem. Pharm. Behav. 2005, 80(4):597-601.
68. Zhen X, Gaswomi S, abdali SA. Regulation of cdk5 and CaMKII by PI-linked dopamine receptor in rat brain. Mol Pharmacol. 2004 Dec; 66(6):1500-7.
69. M Gil, Zhen X. Prenatal cocaine exposure alters GSK3β pathways in select rabbit brain areas. Neurosci Lett. 2003 Oct 9; 349(3):143-146.
70. LQ Jin, Gaswami S, Zhen X. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J. Neurochem. 2003 Apr; 85(2):378-86.
71. Zhen X, C Torries, GP Cai, et al. Inhibition of striatal protein tyrosine phosphatases is associated with D2 dopamine receptor-mediated  supersensitivity in  Parkisno’s rat model. Mol. Pharmacol. 2002, 62:1356-1362.
72. Zhen X, C Torries, E Friedman. Lithium regulates tyrosine phosphatase activity in vivo and in vitro. Psychopharm. 2002 Aug; 162(4):379-84.
73. Zhen X, Claudio Torres, Hoau-Yan Wang. Prenatal exposure to cocaine disrups D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex. J. Neurosci. 2001 Dec 1; 21 (23): 9160-67.
74. Zhen X, J Zhang, E Friedman. D4 dopamine receptor differentially regulates Akt/NF-kB pathways in D4MN9D cells. Mol.Pharmacol. 2001 Oct; 60(4):857-64.
75. J Yu, Reilly G, Zhen X, CE Yellowley, CR Jacobs. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 cells. J. Biol. Chem. 2001 Apr 20; 276(16):13365-13371.
76. Zhen X, W Du, R Anthony, E Friedman and J Harvey. The p38 MAPK is involved in associative learning in rabbits. J. Neurosci. 2001 Aug 1; 21(15): 5513-9.
77. Zhen X, Wu Q and Q Chen. Role of p38 MAPK in PTH-regulated chondrocyte differentiation. J. Biol. Chem. 2001, 276:4879-85.
78. Zhen X, GP Cai (co-first author), K Uryu, E Friedman. Activation of extracellular signal-regulated protein is associated with sensitized locomotive response to D2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J. Neurosci. 2000 Mar 1; 20(5):1849-1857.
79. Zhen X, K Uryu, GP Cai, J Johnson, E Friedman. Age-related impairment of MAP kinase and effect of caloric restriction in brains of Fisher 344 rats.  J. Gerontol. 1999, 54A:B539-548.
80. Zhen X, K Uryu, HY Wang and E Friedman. D1 dopamine receptor agonists mediate activation of p38 MAPK and JNK by a protein Kinase A-dependent mechanism in SK-N-MC cells. Mol. Pharmacol. 1998 Sep, 54(3):453-458.
81. Zhen X, JP Bonjour and J Caverzasio. Platelet-derived growth factor stimulates sodium-dependent Pi transport in osteoblastic cells via phospholipase C and phosphatidylinositol 3’kinase. J. Bone & Mineral Res. 1997, 12:35-42 .
82. Imai, Zhen X, JP Bonjour and J Carverzasio. Aluminum potentiates Pi transport stimulation induced by fluoride in osteoblast-like cells. Am. J. Physiol. 1996, 271(Endocrinol. Metab.34): E694-701.
Dr. Zhen’s research are founded by National Basic Research Program (973), NSFC and National Hi-tech program (863) and other government and private resources.

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