Pharmacology
 
Laboratory of Molecular Neuropathology
Guanghui Wang
Professor
B.S. Fudan University Shanghai Medical School, 1987
Ph.D. University of Tokyo, Japan 2001
wanggh@suda.edu.cn
 

Research Interests:
1. The roles of protein post-modifications in protein degradation and accumulation in Parkinson’s disease
2. The molecular basis of neuroinflammation in Parkinson’s disease

Selected Publications:
1. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G*. The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation. Science Signaling. 2012, 5:ra61.
2. Wang H, Ying Z, Wang G*. Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains. J Biol Chem. 2012, 287:28576-28585.
3. Ren H, Fu K, Mu C, Zhen X, Wang G*. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 2012, 7:40.
4. Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G*. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2012, 31(10): 1311-1322.
5. Ren H, Fu K, Wang D, Mu C, Wang G*. Oxidative DJ-1 interacts with mitochondrial protein BCL-XL. J Biol Chem. 2011, 286(40): 35308-35317.
6. Ma X, Fei E, Fu C, Ren H and Wang G* (2011) Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. 16: 1105-1116.
7. Ying Z, Wang H*, Fan H, Wang G*. The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem. 2011, 286(23): 20835-20844.
8. Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J, Wang G*. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression. J Biol Chem. 2010, 285(49): 38630-38640.
9. Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G*. Parkin mono-ubiquitinates BCL-2 and regulates autophagy. J Biol Chem. 2010, 285(49): 38214-38223.
10. Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N, Wang G*. Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ. 2010, 17(11): 1773-1784.

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