Laboratory of Targeted Anti-Cancer Drug Discovery
Xinliang Mao
M.D. Tongji Medical University, 1994
Ph.D. Peking University, 2000
Postdoctoral Fellow, Stanford University, 2004

Research interests
1. Cancer Pharmacology, anti-cancer drug discovery, Targeted drug discovery
2. Pre-clinical study in anti-cancer drugs
3. Molecular Cancer Biology
Selected Publications (out of 48)
1. Chen G, Han K, Xu X, Du X, Zhang Z, Tang J, Shi M, Wang M, Li J, Cao B, Mao X*. An anti-leishmanial thiadiazine agent induces multiple myeloma cell apoptosis by suppressing the nuclear factor kappaB signaling pathway. Brit. J. Cancer. 2014;110(1): 63-70.
2. Cao B, Li J, Zhu J, Shen M, Han K, Zhang Z, Yu Y, Wang Y, Wu D, Chen S, Sun A, Tang X, Zhao Y, Qiao C, Hou T, Mao X*. The anti-parasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. J. Biol. Chem. 2013;288(47):34181-9.
3. Ling C#, Chen G#, Chen G, Zhang Z, Cao B, Han K, Yin J, Chu A, Zhao Y, Mao X*. A deuterated analog of dasatinib disrupts cell cycle progression and displays anti-non-small cell lung cancer activity in vitro and in vivo. Int J Cancer. 2012;131:2411-9. (# contributed equally)
4. Mao X*, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, Maclean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. A small molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011;117(6):1986-97.
5. Mao X*, Hou T, Cao B, Wang W, Li Z, Chen S, Fei M, Hurren R, Gronda M, Wu D, Trudel S, Schimmer AD. The tricyclic anti-depressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases:in vitro and in silico evidence. Mol Pharmacol. 2011;79(4):672-80.
6. Li X, Wood TE, Sprangers R, Jansen G,  Franke NF, Mao X, Wang X, Zhang Y, VerbruggeSE, Li Z, Trudel S, Chen C, Jamal N, Messner H, Cloos J, Rose D, Navon A, Batey RA,  Kay LE,  Schimmer AD*. A non-competitive chemical proteasome inhibitor synergizes with and overcomes resistance to Bortezomib. J Natl Cancer Inst. 2010, 102(14):1069-82.
7.  Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD*. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010, 115(11):2251-9.
8. Mao X#, Li X#, Sprangers M, Wang X, Vengopal A, Wood T, Zhang Y, Kuntz D, Coe E, Stewart AK, Roase D, Batey RA, Kay LE, and Schimmer AD*. Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma. Leukemia. 2009;23(3):585-90. (# contributed equally)
9. Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Zavareh RB, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD*. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008;112(3):760-9.
10. Tiedemann RE, Mao X, Shi CX, Zhu YX, Palmer SE, Sebag M, Marler R, Chesi M, Fonseca R, Bergsagel PL, Schimmer AD, Stewart AK*. Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. J Clin Invest. 2008;118(5):1750-64.
11. Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey S, Gillis L, Barber DL, Wrana J, Ezzat S, and Schimmer AD*. A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin. Blood. 2007; 110(12):4047-54.
12. Mao X, Seidlitz E, Ghosh K, Murakami Y, and Ghosh HP*. The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res. 2003; 63(22): 7979-7985.
13. Mao X, Seidlitz E, Truant R, Hitt M, and Ghosh HP*. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene. 2004; 23(33):5632-42.

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