Pharmacology
 
Cerebrovascular Pharmacology, Novel Target and Drug Discovery for Stroke Therapy
Huiling Zhang
Professor
PhD, Soochow University, 2005
PDF, Harvard University, 2006
huilingzhang07@hotmail.com
 

Research interests: 
1. Cerebrovascular Pharmacology, novel target and drug discovery for stroke therapy
2.The role of astrocytes in the ischemic stroke 
 Representative publications:
1. Direct protection of neurons and astrocytes by matrine via inhibition of the NF-κB signaling pathway contributes to neuroprotection against focal cerebral ischemia. Brain Res. 2012, 15: 1454: 48-64.
2. Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin. 2011, 32: 1089-1099.
3. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway. Neuroscience. 2011,176: 381-95.
4. Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. Autophagy. 2010,6: 738-753.
5. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Brain Res. 2008, 9: 1234:8-15.
6. Neuroprotective effects of prostaglandin A (1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation. J Neurosci Res. 2008, 86:1132-1141.

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