Drug Research for Hyperlipidemic Diseases
Meilin Xie
M.B. Suzhou Medical College, 1984
Master’s degree of Medicine, Suzhou Medical College, 1990
M.D. China Academy of Chinese Medical Sciences, 1998

Research interests: 
1. Abnormal lipid metabolism-related diseases, especially hyperlipidemia, fatty liver, diabetes, insulin resistance, atherosclerosis, and cardiac hypertrophy
2. Relationship between lipid metabolism and biological clock
Representative publications:
1. Timed high-fat diet in the evening affects hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice.  Wang XY, et al. Genes Nutr., DOI:10.1007/s12263-013-0333-y, Feb.17, 2013, Epub ahead of print.
2. Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.  Zhou F, et al. Lipids, 2012, 47, 987.
3. Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.  Chen R, et al. Toxicol. Appl. Pharm., 2011, 256, 168.
4. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.  Qi ZG, et al. Planta Med., 2011, 77, 231.
5. Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.  Du R, et al. Eur. J. Pharmacol. ,2011, 666, 183.
6. Aspirin inhibits MMP-9 mRNA expression and release via the PPARα/γ and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells.  Xue J, et al. Biomed. Pharmacother., 2010, 64, 118.
7. Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPAR/γ and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes.  Hua YN, et al. Pharmacology, 2009, 83, 18.
8. Osthole regulates hepatic PPARα- mediated lipogenic gene expression in alcoholic fatty liver murine.  Sun F, et al. Phytomedicine, 2010, 17, 669.
9. Inhibitory effect of osthole on alcohol-induced fatty liver in mice.  Sun F, et al. Digest. Liver Dis., 2009, 41, 127.
10. Research progress on pathogenesis of obesity-induced insulin resistance and its therapeutic targets: PPARα/γ.  Qi ZG, et al. Curr. Signal Transd. T., 2012, 7, 177.

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