Molecular Cancer Research and Pharmacology
Yi Zhang
Associate Professor
Ph.D. Pharmacology, Soochow University And Cancer Center, Hershey, Penn State University 2012

Research interests:
1. Targeting Energy Metabolic Pathways as Therapeutic Intervention for Cancer
2. The Importance of Autophagy in Cancer Development and Treatment    
Representative publications:
1. eEF-2 Kinase Dictates Crosstalk between Autophagy and Apoptosis Induced by Akt Inhibition, thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206. Zhang Y, et al. Cancer Res 71(7): 2654-2663, 2011.
2. NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response. Zhang Y, et al. Oncogene 31(8): 1055-1064, 2012.
3. NAC1 and HMGB1 enter a partnership for manipulating autophagy. Zhang Y, et al. Autophagy. 2011 Dec 1;7(12).
4. Dysfunction of  Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis.  Zhang Y, et al. Cancer Res 72(16): 4262-4275, 2012.
5. Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma.  Liu XY, et al. PLoS One 2013 Nov 26;8(11):e81345.
6. Regulation of Autophagy by miR-30d Impacts Sensitivity of Anaplastic Thyroid Carcinoma to Cisplatin. Zhang Y, et al. Biochem Pharmacol 2014 Feb 15;87(4):562-70.

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