Pharmacology
 
Parkinson’s Disease and Molecular Neuropathology
Haigang Ren
Associate Professor
B.S. Southwest University of Science and Technology, 2005
Ph.D. University of Science and Technology of China, 2010
rhg@suda.edu.cn
 

Research interests:
1. Molecular mechanisms of Parkinson’s disease pathogenesis
2. Mitochondrial dysfunction in Neurodegenerative disease
Representative publications:
1. Ren H, Fu K, Mu C, Zhen X, Wang G (2012) L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 7:40.
2. Ren H, Fu K, Wang D, Mu C, Wang G* (2011) Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem. 286: 35308-35317.
3. Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G (2011) DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 31:1311-1322.
4. Ma X, Fei E, Fu C, Ren H, Wang G (2011) Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. DOI: MP.2011.43.
5. Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N, Wang G (2010) Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death & Differentiation 17:1751-1759.
6. Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J, Wang G and Swaab D (2010) Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 133: 3069-3079.
7. Ren H, Fu K, Mu C, Li B, Wang D, Wang G (2010) DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells. Cancer Letters 297:101-108.
8. Zhang T, Wang P, Ren H, Fan J, Wang G (2009). NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity. Mol Cancer Res 7: 1408-1415.
9. Fan J, Ren H, Fei E, Jia N, Ying Z, Jiang P, Wu M, Wang G (2008). Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett 582:1151-1156.
10. Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G (2008). DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity. J Biol Chem. 283:4022-4030.

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