Biophysics, Ion Channels
Xiaohui Sun
Associate Professor
B.S. Huazhong University of Science and Technology, 2000
Ph.D. Huazhong University of Science and Technology, 2007

Research interests:
1. Structure, function and pharmacology of ion channels, especially TRP channels and BK-type Ca2+ and voltage-dependent K+ channels 
2.  Interaction between ion channels
Representative publications:
1. Sun X., Shi J., Delaloye K., et al. The interface between membrane-spanning and cytosolic domains in BK channels is involved in β subunits modulation of gating. J. Neurosci. 33(27):11253-11261, 2013. 
2. Sun X., Zaydman M. A. and Cui J. Regulation of voltage-activated K+ channel gating by transmembrane β subunits. Front. Pharmacol. 3:63, 2012.
3. Sun X., Ding J., Li H., et al. Activation of large-conductance calcium-activated potassium channels by puerarin-The underlying mechanism of puerarin-mediated vasodilation. J. Pharmacol. Exp. Ther. 323(1): 391-397, 2007. 
4. Yang J., Yang H., Sun X., et al. Interaction between residues in the Mg2+-binding site regulates BK channel activation. J. Gen. Physiol. 141(2):217-228, 2013. 
5. Lukacs V., Rives J.M., Sun X., et al. Promiscuous activation of transient receptor potential vanilloid 1 channels by negatively charged intracellular lipids, the key role of endogenous phosphoinositides in maintaining channel activity. J. Biol. Chem. 288(49): 35003-35013, 2013.

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