Pharmacology
 
Neuropharmacology
Fang Lin
Associate Professor
B.S. Ningxia University, 1995
M.S. Nanjing Agriculture University, 1998
Ph.D. China Pharmaceutical University, 2002
bluestonelin@hotmail.com
 

RESEARCH INTERESTS
Huntington’s disease is a neurodegenerative disease. Dr. Lin focuses on mutant huntingtin degradation by autophagy and gene diagnosis.
SELECTED PEER-REVIEWED PUBLICATIONS (* Corresponding Author)
1. Jiang D, Chen K, Lu X, Gao HJ, Qin ZH, Lin F*. Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux. Acta Pharmacol Sin. 2014. 35(1):135-42
2. Lin F, Qin ZH*. Degradation of Misfolded Proteins by Autophagy: Is it a Strategy for Huntington's Disease Treatment? Journal of Huntington’s Disease. 2013. 2:149–157
3. Wu JC, Qi L, Wang Y, Kegel KB, Yoder J, Difiglia M, Qin ZH, Lin F*. The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1. Acta Pharmacol Sin. 2012 Jun;33(6):743-51.
4. Chen LL, Wu JC, Wang LH, Wang J, Qin ZH, Difiglia M, Lin F*. Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes. Acta Pharmacol Sin. 2012 Mar;33(3):385-92.
5. Wang LH, Lin F, Wu JC, Qin ZH. High efficiency adenovirus- mediated expression of truncated N-terminal huntingtin fragment (htt552) in primary rat astrocytes. Acta Biochim Biophys Sin. 2009, 41(4):325-34.
6. LI G, Lin F, Xue HW, Genome-wide analysis of the phospholipase D family in Oryza sativa and functional characterization of PLD beta 1 in seed germination. Cell research, 2007, 17(10):881-94
7. Lin F, Wu JC, Wang Y, Qin ZH*, Huntingtin cleavage induced by thrombin in vitro, Acta Biochimica et Biophysica Sinica, 2007,39(1): 15-18.
8. Wang LH, Lin F*, Treatment of Huntington’s Disease, Neuroscience Bulletin, 2005, 21(3):230-235. Corresponding author
9. Lin F, Xu SL, Ni WM, Chu ZQ, Xu ZH, Xue HW*, Identification of ABA-responsive genes in rice shoots via cDNA macroarray. Cell research, 2003, 13(1): 59-68.
BOOK CHAPTERS
Lin F, Qin ZH, The Methods for Autophgy Research. Autophagy—Biology and Diseases. Science Press, 2011, 49-64
PATENT
Qin ZH, Lin F, Wang J, A set of primers and a rapid and simple detection method of CAG repeats in IT15 genes. China National Patent (ZL200510041523.1), Jan, 2008.

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