Pharmacology
 
Neuropharmacology
Yan Wang
Associate Professor
B.S. & M.S. & Ph.D. Soochow University, Suzhou, China 2002 & 2005 & 2010
yanwang@suda.edu.cn
 

RESEARCH INTERESTS
Neurodegenerative diseases; excitotoxicity; autophagy and apoptosis.
SELECTED Peer-reviewed publication (* Corresponding Author)
1. Wang YR, Qin S, Han R, Wu JC, Liang ZQ, Qin ZH, Wang Y*. Cathepsin L plays a role in quinolinic acid-induced NF-κB activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.
2. Wang Y, Qin ZH. Coordination of autophagy with other cellular activities. Acta Pharmacol Sin. 2013. 34(5):585-594.
3. Dong XX, Wang YR, Qin S, Liang ZQ, Liu BH, Qin ZH, Wang Y*. p53 Mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons. Neuroscience. 2012; 207: 52-64. 
4. Wang Y, Qin ZH. Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis. 2010; 15: 1382-1402. 
5. Wang Y, Dong XX, Cao Y, Liang ZQ, Han R, Wu JC, Gu ZL, Qin ZH. p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. European Journal of Neuroscience. 2009; 30(12): 2258-2270. 
6. Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, Qin ZH. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy. 2008; 4(2): 214-226.
7. Wang Y, Gu ZL, Cao Y, Liang ZQ, Han R, Bennett MC, Qin ZH. Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum. Brain Research. 2006; 1071(1): 245-249.
8. Dong XX, Wang Y, Qin ZH. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol Sin. 2009; 30(4): 379-387.
9. Zhang XD, Wang Y, Wang Y, Zhang X, Han R, Wu JC, Liang ZQ, Gu ZL, Han F, Fukunaga K, Qin ZH. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy. 2009; 5(3): 339-350.
RESEARCH SUPPORT
1. 2011-2013: Presided over the project supported by the National Natural Science Foundation of China entitled “The mechanisms and significance of cathepsin L degradation of IκB-a in neurotoxicity”.
2. 2010-2013: Participating in the project supported by the National Natural Science Foundation of China entitled “Molecular mechanisms of the interactive relationship of autophagy and apoptosis and its roles in the survival of neuronal cells”. 
3. 2007-2009: Presided over the project supported by the Graduate Student Fellowship of Jiangsu Province entitled “The roles of mitochondria in the activation of autopahgy mediated by NMDA receptor”.
SELECTED HONORS/AWARDS
•Excellent doctoral dissertation of JiangSu Province (2011)
•Excellent Presentation at Neuro2010 (2010)
•GSK “Tomorrow’s star” (2010)
•Excellent natural science thesis of SuZhou (2010)
•Excellent Research Paper of Natural Science of SuZhou (2006)
•Excellent Master Thesis of JiangSu Province (2006)
•Excellent Thesis of National Pharmacology Conference & Chinese Young Researchers’ Symposium on Pharmacology (2005)
•Excellent Scholarship of Soochow University (2004)
•Excellent Graduate of Soochow University (2002)

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