Molecular and Cellular Neuropharmacology
Zheng Ying
B.S. University of Science and Technology of China, 2004
Ph.D. University of Science and Technology of China, 2009

Research interests:
1. Basic Mechanisms of ALS and other Neurodegenerative Diseases
2. Protein Quality Control in Neurodegenerative Diseases
Representative publications:
1. Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between bcl-xl and bax. Zhou L,;et al. Neuroscience. 2013,243C:14-21. (*Co-corresponding author)
2. Sequestosome 1/p62 upregulates autophagy in a Bcl-2 dependent manner. Zhou L;et al. Acta Pharmacol Sin. 2013,34(5):651-6. (*Co-corresponding author)
3. Ubiquitin Proteasome System as the Potential Targets for the Treatment of Neurodegenerative Diseases. Ying Z;et al. Curr Pharm Des. 2013,19(18):3305-14. (*Co-first author)
4. Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains. Wang H;et al. J Biol Chem. 2012,287(34):28576-85. (*Co-first author)
5. Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice. Farr GW;et al. Protein Sci. 2011,20(10):1692-6.
6. The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin. Ying Z;et al. J Biol Chem. 2011,286(23):20835-44.
7. Structural basis of pre-mRNA recognition by the human cleavage factor I(m) complex. Li H; et al. Cell Res. 2011,21(7):1039-51.
8. Degradation of mutant TDP-43 by autophagy and the ubiquitin-proteasome system. Wang X; et al. Neurosci Lett. 2010,469(1):112-116.
9. Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Ying Z;et al.Hum Mol Genet.2009, 18(22):4268-81.
10. Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. Fan J; et al. FEBS Lett. 2008,582(7):1151-6.

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