Cardiovascular Pharmacology & Neuropharmaoclogy
Rui Sheng
B.S. & M.S. China Pharmaceutical University, 1997& 2000
Ph.D. Soochow University, 2006

Research interests:

(1) The molecular mechanisms and therapeutic drugs of cardiovascular diseases including stroke, preconditioning and cardiac hypertrophy.

(2) The role of autophagy and endoplasmic reticulum stress in cardiovascular diseases.


Representative publications:  (first author/corresponding author)

[1]  Sheng R*, Chen JL, Qin ZH . Cerebral Conditioning: Mechanisms and Potential Clinical Implications. eNeuroscience, 2018, 0(0): doi:10.14336/EN.2018.0128

[2]  Song DD, Zhou JH, Sheng R*. Regulation and function of sphingosine kinase 2 in diseases. Histol Histopathol. 2017 Oct 19:11939(*corresponding author).

[3]  Song DD, Zhang TT, Chen JL, Xia YF, Qin ZH, Waeber C, Sheng R*. Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain. Cell Death Dis. 2017 Jul 6;8(7): e2912 (*corresponding author)

[4]  Zhou JH, Zhang TT, Song DD, Xia YF, Qin ZH, Sheng R*. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. Sci Rep. 2016; 6:27096.(*corresponding author)

[5]  Sheng R*, Qin ZH. The divergent roles of autophagy in ischemia and preconditioning. Acta Pharmacol Sin. 2015;36(4):411-20(*corresponding author).

[6]  Zhang XY, Zhang TT, Song DD, Zhou J, Han R, Qin ZH, Sheng R*. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015;8:20(*corresponding author).

[7]  Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 2014; 289(30): 20845-57.

[8]  Gao B, Zhang XY, Han R, Zhang TT, Chen C, Qin ZH, Sheng R#. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacol Sin 2013;34(5):657-66. (#corresponding author)

[9]  Sheng R, Gu ZL, Xie ML. Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Int J Cardiol 2013;162(3):199-209.

[10]   Sheng R, Liu XQ, Zhang LS, Gao B, Han R, Wu YQ, Zhang XY, Qin ZH. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Autophagy 2012; 8(3): 310-325.

[11]                    Sheng R, Zhang LS, Han R, Gao B, Liu XQ, Qin ZH. Combined Prostaglandin E1 and lithium induces bcl-2 and heat shock proteins while inhibits p53 in a rat model of cerebral ischemia1 Acta Pharmacol Sin 2011; 32: 303-10.

[12]             Sheng R, Zhang LS, Han R, Liu XQ, Gao B, Qin ZH. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy 2010, 6: 482-94.

[13]   Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxides- induced apoptosis and telomere attrition. Eur J Pharmacol 2010, 641:199-206.

[14]   Sheng R, Gu ZL*, Xie ML, Zhou WX, Guo CY. EGCG inhibits proliferation of cardiac fibroblasts in the rats with cardiac hypertrophy. Planta Medica. 2009, 75:113-20.

[15]   #Wen YD, #Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Kohji F, Qin ZH*. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008; 4(6): 762-9. (#: These authors contribute equally to this work)

[16]   Sheng R, Gu ZL*, Xie ML, Zhou WX, Guo CY. EGCG inhibits cardiomyocyte apoptosis in pressure overload induced cardiac hypertrophy rats and protects cardiomyocyte from oxidative stress. Acta Pharmacol Sin 2007, 28(2): 191-201.

[17]            Sheng R, Liu GQ*. EDTa tetrahydroacridine derivative, inhibits cerebral ischemia and protects rat cortical neurons against glutamate and NO-induced injury. Acta Pharmacol Sin 2003; 24(5): 390-393.

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