Pharmacology
 
Cardiovascular Pharmacology & Neuropharmaoclogy
Rui Sheng
Professor
B.S. China Pharmaceutical University, 1997
M.S. China Pharmaceutical University, 2000
Ph.D. Soochow University, 2006
sheng_rui@163.com
 

Research interests:
1. The molecular mechanisms of cerebral ischemia and preconditioning, especially the role of apoptosis, autophagy and endoplasmic reticulum stress in cerebral ischemia and ischemic preconditioning
2. Telomere signaling in cardiovascular diseases and cerebral ischemia
Representative publications: (*: corresponding author)
1. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Gao B; et al. Acta Pharmacol Sin. 2013; 34(5): 657-66.
2.  Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Sheng R; et al. Int J Cardiol. 2013;162(3):199-209.
3. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Sheng R; et al. Autophagy. 2012; 8(3): 310-325.
4. Combined Prostaglandin E1 and lithium induces bcl-2 and heat shock proteins while inhibits p53 in a rat model of cerebral ischemia1. Sheng R; et al. Acta Pharmacol Sin. 2011; 32: 303-10.
5. Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxides- induced apoptosis and telomere attrition. Sheng R; et al. Eur J Pharmacol .2010, 641:199-206.
6. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Sheng R; et al. Autophagy. 2010; 6(4): 482-494..
7. EGCG inhibits proliferation of cardiac fibroblasts in the rats with cardiac hypertrophy. Sheng R; et al. Planta Medica. 2009, 75:113-20.
8. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Wen YD; et al. Autophagy. 2008; 4(6): 762-9. (#: These authors contribute equally to this work)
9. EGCG inhibits cardiomyocyte apoptosis in pressure overload induced cardiac hypertrophy rats and protects cardiomyocyte from oxidative stress. Sheng R; et al. Acta Pharmacol Sin. 2007, 28(2): 191-201.
10. EDT,a tetrahydroacridine derivative, inhibits cerebral ischemia and protects rat cortical neurons against glutamate and NO-induced injury. Sheng R; et al. Acta Pharmacol Sin. 2003,24(5): 390-393.
 

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