Cancer Pharmacology
Zhongqin Liang
Master’s degree of Medicine, Suzhou Medical College, 1996

Research interests :
1. Cancer Pharmacology
2. Pre-clinical study in anti-cancer drugs

Representative publications:
1. Wang WJ, Long LM, Yang N, Zhang QQ, Ji WJ, Zhao JH, Qin ZH, Wang Z, Chen G, Liang ZQ . NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro. Acta Pharmacol Sin. 2013 ;34(5):681-90.
2. Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q, Liang Z. Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy. Cancer Sci. 2012 ; 103(4):684-90.
3. Xiang B, Fei X, Zhuang W, Fang Y, Qin Z, Liang Z. Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells. Brain Res. 2011 。28;1387:29-38.
4. Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer. 2011,129, 2720–2731.
5. Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z. Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett. 2011 ,1;489(1):62-7.
6. Zhuang W, Li B, Long L, Chen L, Huang Q, Liang ZQ. Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res. 2011 ,31;1371:7-15.
7. Fei XF, Qin ZH, xiang B, Li LY, Liang ZQ. Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Research,2009,1264.85-97.
8. Jun Li, Zhenghong Qin,and Zhongqin Liang. The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer ,2009, 9:215.
9. Zhang L, Gu ZL, Qin ZH, Liang ZQ. Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro. Acta Pharmacologica Sinica. 2008, 29 (7): 800-807.
10. Li LY, Zhao XL, Fei XF, Gu ZL, Qin ZH, Liang ZQ.  Bilobalide inhibits 6-OHDA -induced activation of NF-κB and loss of dopaminergic neurons in Rat Substantia Nigra. Acta Pharmacologica Sinica.2008, 29 (5): 539-547.
11. Yan CH, Gu ZL,Yang YP, Reid P, Qin ZH, Liang ZQ. Autophagy is involved in cytotoxic effects of crotoxin in MCF-7 cells. Acta Pharmacological Sin. 2007, 28: 540-548.

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