Longtai Zheng
Associate Professor
B.S. Yanbian University, 1998
Ph.D. Kyung Hee University School of Medicine, Seoul, Korea, 2006

Research interests:
1. The molecular mechanisms of microglial polarization in the glioma microenvironment
2. The role of glial cells in neurodegenerative diseases
Representative publications:
1. Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: discovery of a novel neuroinflammation inhibitor. Yang YX, et al. Bioorg Med Chem Lett. 2014, 24:1222-7.
2. Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays. Xu L, et al. J Med Chem. 2014,57:3737-45.
3. Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA. Jeon H, et al. Exp Cell Res. 2011, 17:2007-18.
4. Pro-apoptotic role of integrin 3 in glioma cells. Kim JH, et. al. J. Neurochem 2011, 117(3):494-503.
5. Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. Zheng LT, et al. J. Neurochem 2009, 111:1238-1251.
6.The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production. Zheng LT, et al. J. Neurochem 2008, 107:1225-1235.
7. Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity. Zheng LT, et al. European journal of pharmacology 2008, 588:106-113.
8. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Zheng LT, et al. International immunopharmacology 2008, 8:484-494.

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