Cancer Pharmacology
Li Zhang
Associate Professor
B.S. Harbin Medical University, 1994
MD & Ph.D. Soochow University, Suzhou, China 2003 & 2008

Research Interests
The research interests in Jinming Yang’s laboratory focus on the molecular determinants of sensitivity/ resistance to anticancer treatments and target cancer stem cells differentiation as therapeutic intervention for cancer.
1.Zhang L, Ren X, Cheng Y, Liu X, Allen JE, Zhang Y, Yuan Y, Huang SY, Yang W, Berg A, Webb BS, Connor J, Liu CG, Lu Z, El-Deiry WS, Yang JM. The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype. Cancer Biol Ther. 2014 May;15(5):602-11.
2.Ji C, Zhang L, Cheng Y, Patel R, Wu H, Zhang Y, Wang M, Ji S, Belani CP, Yang JM, Ren X. Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer. Cancer Biol Ther. 2014 May;15(5):570-7.
3.Zhang Y, Yang WQ, Zhu H, Qian YY, Zhou L, Ren YJ, Ren XC, Zhang L, Liu XP, Liu CG, Ming ZJ, Li B, Chen B, Wang JR, Liu YB, Yang JM. Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin.  Biochem Pharmacol. 2014 Feb 15;87(4):562-70
4.Liu XY, Zhang L, Wu J, Zhou L, Ren YJ, Yang WQ, Ming ZJ, Chen B, Wang J, Zhang Y, Yang JM.Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma. PLoS One. 2013 Nov 26;8(11):e81345. 
5.Zhang L, Ren X, Cheng Y, Huber-Keener K, Liu X, Zhang Y, Yuan YS, Yang JW, Liu CG, Yang JM.  Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.  Biochem Pharmacol2013 Sep 15; 86(6):726-733.
6.Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, Patel R, Wu H, Huber-Keener K, Yang JW, Liu D, Spratt TE, Yang JM. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis. 2013 Jul 18;4:e731.
7.Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM. Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy. 2013 Feb 1;9(2):208-19.
8.Liu XY, Zhang L, Zhang Y, Yang JM.Roles of eEF-2 kinase in cancer.Chin Med J (Engl). 2012 Aug;125(16):2908-13.
9.Cheng Y, Zhang Y, Zhang L, Ren X, Huber-Keener KJ, Liu X, Zhou L, Liao J, Keihack H, Yan L, Rubin E, Yang JM. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther. 2012 Jan;11(1):154-64.
10.Zhang Y, Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu D, Qin ZH, Shih IM, Yang JM.NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene. 2012 Feb 23;31(8):1055-64.
11.Cheng Y, Sk UH, Zhang Y, Ren X, Zhang L, Huber-Keener KJ, Sun YW, Liao J, Amin S, Sharma AK, Yang JM. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS One. 2012;7(4):e35104..
12.Zhang Y, Cheng Y, Ren X, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang S, Wang J, Wang HG, Shih IeM, Yang JM. Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Res. 2012 Aug 15;72(16):4262-75.
13.Zhang L, Zhang Y, Liu XY, Qin ZH, Yang JM. Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacologica Sinica 2011, 32: 361–367.
14.Zhang Y, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun. 2011 Oct 14;414(1):129-34.
15.Zhang L, Gu ZL, Qin ZH, Liang ZQ. Effect of Curcumin on adhesion of platelets to BMECs in vitro. Acta Pharmacologica Sinica 2008, 29(7):800-807.
16.Zhang L, Gu ZL, Qin ZH. Regulatory genes controlling neural stem cells differentiation into neurons. Neurosci Bull. 2006, 22(5):294-300.
Grant Support
1.Medical department of Suzhou University Graduate School Innovation Fund 2006
2. Natural Science Foundation of Jiangsu provincial Colleges and Universities (08KJB310010) 2008
3. Natural Science Foundation of Jiangsu Province of China (BK2010224) 2010
4.National Natural Science Foundation of China (81101913) 2012

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