Pharmacology
 
Mechanism of hyperalgesia in primary afferent
Yi Zhu
Associate Professor
Ph.D. University of Maryland 2011
M.S. Soochow University 2004
B.S. China Pharmaceutical University 1999
yzhu@suda.edu.cn
 

Research Interest
GABAA receptor function in the regulation of neuronal excitability, mechanism of inflammatory pain
Representative Publications
1. Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott. Elife, Elife 2014 1;3:e02370. Epub 2014 Apr 1 
2. Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats. Zhu Y, Zhang XL, Gold MS. Neuroscience. 2013 Oct 14;256C:1-9.
3. Inflammation-induced shift in spinal GABAA signaling is associated with a tyrosine kinase-dependent increase in GABAA current density in nociceptive afferents.Zhu Y, Dua S, Gold MS. J Neurophysiol. 2012 Nov;108(9):2581-93
4. Persistent inflammation increases GABA-induced excitation of rat cutaneous dorsal root ganglion neurons in vitro.Zhu Y, Lu SG, Gold MS. Neuroscience. 2012  Sep 18;220:330-40. 
5. Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA2 production and platelet. Zhu Y, Gu ZL, Liang ZQ, Zhang HL, Qin ZH.  Acta Pharmacologica Sinica2006 May;27(5): 549-554.

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