Mechanism of hyperalgesia in primary afferent
Yi Zhu
Associate Professor
Ph.D. University of Maryland 2011
M.S. Soochow University 2004
B.S. China Pharmaceutical University 1999

Research Interest
GABAA receptor function in the regulation of neuronal excitability, mechanism of inflammatory pain
Representative Publications
1. Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott. Elife, Elife 2014 1;3:e02370. Epub 2014 Apr 1 
2. Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats. Zhu Y, Zhang XL, Gold MS. Neuroscience. 2013 Oct 14;256C:1-9.
3. Inflammation-induced shift in spinal GABAA signaling is associated with a tyrosine kinase-dependent increase in GABAA current density in nociceptive afferents.Zhu Y, Dua S, Gold MS. J Neurophysiol. 2012 Nov;108(9):2581-93
4. Persistent inflammation increases GABA-induced excitation of rat cutaneous dorsal root ganglion neurons in vitro.Zhu Y, Lu SG, Gold MS. Neuroscience. 2012  Sep 18;220:330-40. 
5. Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA2 production and platelet. Zhu Y, Gu ZL, Liang ZQ, Zhang HL, Qin ZH.  Acta Pharmacologica Sinica2006 May;27(5): 549-554.

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